Replace symbols with regex or with replace

import re
import timeit

regex = re.compile(r'[.,?!\|/@]')
line = 'q@wertysiodhaorhgsdfgsdf/g|sdhgae.,asrg,asrgargarg,.aer.g,aerg!qmfpoibhsdfoinjbosinr?!..,'


def with_regex():
    my_line = line
    my_line = regex.sub('', my_line)


def with_replace():
    my_line = line
    for c in '.,?!\\|/@':
        my_line = my_line.replace(c, '')


timeit.timeit(with_regex)
timeit.timeit(with_replace)

'''
>>> timeit.timeit(with_regex)
3.323782834816426
>>> timeit.timeit(with_replace)
2.9493549943281825
'''

# 2 ################################################################################

import re
import timeit

regex = re.compile(r'[.,?!\|/@]')
line = 'q@wertysiodhaorhgsdfgsdf/g|sdhgae.,asrg,asrgargarg,.aer.g,aerg!qmfpoibhsdfoinjbosinr?!..,'
line = line * 1000


def with_regex():
    my_line = line
    my_line = regex.sub('', my_line)


def with_replace():
    my_line = line
    for c in '.,?!\\|/@':
        my_line = my_line.replace(c, '')


timeit.timeit(with_regex, number=5000)
timeit.timeit(with_replace, number=5000)

'''
>>> timeit.timeit(with_regex, number=5000)
14.224216839779407
>>> timeit.timeit(with_replace, number=5000)
5.4049051833698005
>>>
'''

# 3 ################################################################################

import re
import timeit

regex = re.compile(r'[.,?!\|/@]')
line = 'q@wertysiodhaorhgsdfgsdf/g|sdhgae.,asrg,asrgargarg,.aer.g,aerg!qmfpoibhsdfoinjbosinr?!..,'
line = line * 1000


def with_regex_wrapper(_line):
    def with_regex():
        my_line = _line
        my_line = regex.sub('', my_line)
        return my_line
    return with_regex


def with_replace_wrapper(_line):
    def with_replace():
        my_line = _line
        for c in '.,?!\\|/@':
            my_line = my_line.replace(c, '')
        return my_line
    return with_replace


timeit.timeit(with_regex_wrapper(line), number=5000)
timeit.timeit(with_replace_wrapper(line), number=5000)


'''
>>> timeit.timeit(with_regex_wrapper(line), number=5000)
14.298113452276521
>>> timeit.timeit(with_replace_wrapper(line), number=5000)
5.418057598813073
'''