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DSIP (Delta sleep-inducing peptide) graceyu52@hotmail.com. b

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Nov 2nd, 2017
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  1. DSIP (Delta sleep-inducing peptide) graceyu52@hotmail.com. body building
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  5. Wuhan Magic Biotechnology Co., Ltd.
  6. skype:mary whmoli
  7. wechat/QQ.920821374
  8. Email:graceyu52@hotmail.com.
  9. whatsapp:+8613349906569
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  13. MF：   C35H48N10O15
  14. MW：   848.81
  15. CAS：  62568-57-4
  16. Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.
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  18. Its aminoacid sequence is Тrр-Аlа-Gly-Gly-Asp-Ala-Ser-Gly-Glu. However, it is the only neuropeptide in history whose gene is unknown, raising serious questions regarding the actual existence of this peptide in nature.
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  20. DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif: N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C
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  22. It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids.In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.
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  24. In the brain its action may be mediated by NMDA receptors.In another study Delta sleep-inducing peptide stimulated Acetyltransferase activity through α1 receptors in rats. It is unknown where DSIP is synthesized.
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  26. In vitro it has been found to have a low molecular stability with a half life of only 15 minutes due to the action of a specific aminopeptidase-like enzyme.It has been suggested that in the body it complexes with carrier proteins to prevent degradation, or exists as a component of a large precursor molecule, but as yet no structure or gene has been found for this precursor.
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  30. Wuhan Magic Biotechnology Co., Ltd.
  31. skype:mary whmoli
  32. wechat/QQ.920821374
  33. Email:graceyu52@hotmail.com.
  34. whatsapp:+8613349906569
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