// Create a product model using MagentoCatalogModelProductFactory
$productModel = $this->productFactory->create();

// Set the default values
$productModel
  ->setStoreId(0)
  ->setName($name)
  ->setAttributeSetId($productModel->getDefaultAttributeSetId())
  ->setWebsiteIds([1,2])
  ->setVisibility(4)
  ->setUrlKey($urlKey)
  ->setStatus(2)
  ->setTypeId('simple')
  ->setPrice(10)
  ->save();

// Reload product
$productStoreView = $this->productFactory->create()
  ->load($productModel->getId())
  ->setStoreId(1)
  ->setDescription('Desc for store view 1')
  ->save();

$productStoreView = $this->productFactory->create()
  ->load($productModel->getId())
  ->setStoreId(2)
  ->setDescription('Desc for store view 2')
  ->save();

<?php

use MagentoFrameworkAppBootstrap;

require __DIR__ . '/../app/bootstrap.php';

$bootstrap = Bootstrap::create(BP, $_SERVER);

$obj = $bootstrap->getObjectManager();

$state = $obj->get('MagentoFrameworkAppState');
$state->setAreaCode('frontend');

$product = $obj->get('MagentoCatalogModelProduct');

$product
    ->setName('Random name ' . time())
    ->setSku(time())
    ->setPrice(0)
    ->setStatus(2)// Disabled
    ->setWebsiteIds([1, 2])
    ->setVisibility(4)
    ->setAttributeSetId($product->getDefaultAttributeSetId())
    ->setTypeId('simple')
    ->save();

echo "Saved product ID " . $product->getId() . "n";

$obj->create('MagentoCatalogModelProduct')
    ->load($product->getId())
    ->setStoreId(1)
    ->setDescription('Description store view 1')
    ->save();

$obj->create('MagentoCatalogModelProduct')
    ->load($product->getId())
    ->setStoreId(2)
    ->setDescription('Description store view 2')
    ->save();

/** @var  MagentoCatalogModelProductFactory */
protected $productFactory;

/** @var  MagentoCatalogModelResourceModelProduct */
protected $productResourceModel;

public function __construct(
    MagentoCatalogModelProductFactory $productFactory,
    MagentoCatalogModelResourceModelProduct $productResourceModel
)
{
    $this->productFactory = $productFactory;
    $this->productResourceModel = $productResourceModel;
}


private function setStoreViewPrice($productId, $storeId, $price)
{
    $product = $this->productFactory->create();
    $this->productResourceModel->load($product, $productId);
    $product->setStoreId($storeId);
    $product->setPrice($price);
    $this->productResourceModel->saveAttribute($product, 'price');
}

$this->objectManager->create('MagentoCatalogModelProduct')
    ->load($product->getId())
    ->setStoreId($storeviewId)
    ->setStatus($storeStatus)
    ->setDescription('Store description')
    ->setName(null) // Use default
    ->setPrice($price) // Store price
    ->setTaxClassId(null) // Use default
    ->setVisibility(null) // Use default
    ->setCountryOfManufacture(null) // Use default
    ->save();

$productStoreView = $this->productFactory->create()
  ->load($productModel->getId());

 $productStoreView->setDescription('Desc for store view 1');
 $productStoreView->setStoreId(1);
 $productStoreView->save();

$objectManager = MagentoFrameworkAppObjectManager::getInstance();
        $objectManager->create('MagentoCatalogModelProduct')->load(2)->setStoreId(1)->setDescription('english content')->save();
        $objectManager->create('MagentoCatalogModelProduct')->load(2)->setStoreId(2)->setDescription('french content')->save();