yes! which is to say: punch up the fantasy elements a tiny bit while retaining the cyberpunk
basically: the Great Grinding Wormgod was the result of an Umbradyne planetcracking effort- it was meant to core whole planets for resources, and was roughly the size of, you know. earth.
by localizing so much greed, industrialism, and labor-misery in one place, they accidentally created the perfect vessel for an extradimensional industrial horror, which promptly took a massive bite out of earth and then dug its way out of its home dimension, leading to a massive wound in the universe approximately ten miles out of the atmosphere of earth
doing this caused an event commonly called the Renaissance of Phenotype: people, apropos of nothing, started mutating over time to better reflect their general place in life- their job, hopes, dreams, impulses, possessions, and soul all play tiny factors in determining if you mutate. most people end up mutated into their ideal forms- their ideal gender, number of limbs, eyes, senses, and level of sentience.
"but what about the really bad people nohi"

they turn into vessels for devils! extradimensional consciousness patterns that cannot come into being on their own, and require a host in order to manifest.
Volk's war and the ensuing florotoxin were the result of Umbradyne and the other megacorps scrambling to contain devil threats in the later days of the Renaissance of Form.