/etc/nginx/sites-enabled/default

    server {
        listen 80 default_server;
        listen [::]:80 default_server ipv6only=on;

        root /usr/share/nginx/html;
        index index.html index.htm;

        # Make site accessible from http://localhost/
        server_name localhost;

        location / {
            # First attempt to serve request as file, then
            # as directory, then fall back to displaying a 404.
            try_files $uri $uri/ =404;
            # Uncomment to enable naxsi on this location
            # include /etc/nginx/naxsi.rules
        }

        # Only for nginx-naxsi used with nginx-naxsi-ui : process denied requests
        #location /RequestDenied {
        #       proxy_pass http://127.0.0.1:8080;
        #}

        #error_page 404 /404.html;

        # redirect server error pages to the static page /50x.html
        #
        #error_page 500 502 503 504 /50x.html;
        #location = /50x.html {
        #       root /usr/share/nginx/html;
        #}

        # pass the PHP scripts to FastCGI server listening on 127.0.0.1:9000
        #
        #location ~ \.php$ {
        #       fastcgi_split_path_info ^(.+\.php)(/.+)$;
        #       # NOTE: You should have "cgi.fix_pathinfo = 0;" in php.ini
        #
        #       # With php5-cgi alone:
        #       fastcgi_pass 127.0.0.1:9000;
        #       # With php5-fpm:
        #       fastcgi_pass unix:/var/run/php5-fpm.sock;
        #       fastcgi_index index.php;
        #       include fastcgi_params;
        #}

        # deny access to .htaccess files, if Apache's document root
        # concurs with nginx's one
        #
        #location ~ /\.ht {
        #       deny all;
        #}
    }


    upstream wsgi_mydomain.ru {
       server unix:/srv/socks/mydomain.ru.sock;
    }

/etc/nginx/sites-enabled/mydomain.conf

    server {
        listen      80;
        server_name mydomain.ru;
        charset     utf8;
        autoindex   off;
        access_log  /srv/logs/mydomain.ru_access.log;
        error_log   /srv/logs/mydomain.ru_error.log error;

        set         $project_home       /srv/www/mydomain.ru;
        set         $media_home      /srv/www/httpdocs;

        root        $project_home;


        location / {
            root            $project_home;
            try_files       $uri    @webadm;
        }

        location /images {
            root          $media_home/media;
            expires       1w;
        }

        location /img {
            root            $media_home/media;
            expires         1w;
        }

        location /css {
            root          $media_home/media;
            expires       1d;
        }

        location /js {
            root          $media_home/media;
            expires       1d;
        }
        location /fonts {
            root          $media_home/media;
            expires       1w;

        }
        location /files {
            root            $media_home/media;
            expires         1w;
        }

        location /static {
            root            $media_home;
            expires         1d;
        }

        location /media {
            root            $media_home;
            expires         1w;
        }

        gzip             on;
        gzip_min_length  1000;
        gzip_proxied     expired no-cache no-store private auth;
        gzip_disable     "MSIE [1-6]\.(?!.*SV1)";
        gzip_static      on;
        gzip_types       text/plain application/xml text/css application/javascript application/x-javascript text/javascript application/x-woff image/gif image/jpeg image/pjpeg image/png;

        location ~* ^.+\.(ogg|ogv|svg|svgz|eot|otf|woff|mp4|ttf|rss|atom|jpg|jpeg|gif|png|ico|zip|tgz|gz|rar|bz2|doc|xls|exe|ppt|tar|mid|midi|wav|bmp|rtf|css|js)$ {
            expires 7d;
        }

        location @webadm {
            uwsgi_pass              wsgi_mydomain.ru;
            uwsgi_read_timeout      2400;
            include                 uwsgi_params;
        }
    }