myproject/
    media/
    myapp/
        templates/
            myapp/
                list.html
        forms.py
        models.py
        urls.py
        views.py
    __init__.py
    manage.py
    settings.py
    urls.py

...
MEDIA_ROOT = '/path/to/myproject/media/'
MEDIA_URL = '/media/'
...

...
class Document(models.Model):
    docfile = models.FileField(upload_to='documents/%Y/%m/%d')
...

...
class DocumentForm(forms.Form):
    docfile = forms.FileField(
        label='Select a file',
        help_text='max. 42 megabytes'
    )
...

...
from django.shortcuts import render_to_response
from django.template import RequestContext
from django.http import HttpResponseRedirect

from myproject.myapp.models import Document
from myproject.myapp.forms import DocumentForm
...
def list(request):
    # Handle file upload
    if request.method == 'POST':
        form = DocumentForm(request.POST, request.FILES)
        if form.is_valid():
            newdoc = Document(docfile = request.FILES['docfile'])
            newdoc.save()

            # Redirect to the document list after POST
            return HttpResponseRedirect(reverse('myapp.views.list'))
    else:
        form = DocumentForm() # A empty, unbound form

    # Load documents for the list page
    documents = Document.objects.all()

    # Render list page with the documents and the form
    return render_to_response(
        'myapp/list.html',
        {'documents': documents, 'form': form},
        context_instance=RequestContext(request)
    )

from django.conf.urls.defaults import patterns, include, url
from django.conf import settings
from django.conf.urls.static import static

urlpatterns = patterns('',
    (r'^', include('myapp.urls')),
) + static(settings.MEDIA_URL, document_root=settings.MEDIA_ROOT)

from django.conf.urls.defaults import patterns, url

urlpatterns = patterns('myapp.views',
    url(r'^list/$', 'listview', name='list'),
)

...
<!-- List of uploaded documents -->
{% if documents %}
    <ul>
    {% for document in documents %}
        <li><a href="{{ document.docfile.url }}">{{ document.docfile.name }}</a></li>
    {% endfor %}
    </ul>
{% else %}
    <p>No documents.</p>
{% endif %}

<!-- Upload form. Note enctype attribute! -->
<form action="{% url list %}" method="post" enctype="multipart/form-data">
    {% csrf_token %}
    {{ form.non_field_errors }}
    {{ form.docfile.help_text }}
    {{ form.docfile.label_tag }}
    {{ form.docfile.errors }}
    {{ form.docfile }}
    <input type="submit" value="Upload" />
</form>
...

<form method="post" enctype="multipart/form-data">
    <input type="file" name="myfile" />
    <input type="submit" name="submit" value="Upload" />
</form>

def myview(request):
    request.FILES['myfile'] # this is my file

import tempfile
import shutil

FILE_UPLOAD_DIR = '/home/imran/uploads'

def handle_uploaded_file(source):
    fd, filepath = tempfile.mkstemp(prefix=source.name, dir=FILE_UPLOAD_DIR)
    with open(filepath, 'wb') as dest:
        shutil.copyfileobj(source, dest)
    return filepath

entry = form.save()

            # save uploaded file
            if request.FILES['myfile']:
                entry.myfile.save(request.FILES['myfile']._name, request.FILES['myfile'], True)