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<?php
MagentoFrameworkComponentComponentRegistrar::register(
MagentoFrameworkComponentComponentRegistrar::MODULE,
'vendor_modulename',
__DIR__
);

<config xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"  xsi:noNamespaceSchemaLocation="../../../../../../lib/internal/Magento/Framework/ObjectManager/etc/config.xsd">
<preference for="MagentoSalesBlockAdminhtmlOrderCreate" type="vendormodulenameBlockAdminhtmlOrderCreate" />
</config>

<?xml version="1.0"?>
<config xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:noNamespaceSchemaLocation="urn:magento:framework:Module/etc/module.xsd">
    <module name="vendor_modulename" setup_version="1.0.0">
        <sequence>
            <module name="Magento_Sales"/>
        </sequence>
    </module>
</config>

<?xml version="1.0"?>
<page xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"  xsi:noNamespaceSchemaLocation="urn:magento:framework:View/Layout/etc/page_configuration.xsd">
    <body>
        <referenceBlock name="order_totals">
            <action method="setTemplate">
                <argument name="template" translate="true" xsi:type="string">vendor_modulename::order/create/totals.phtml</argument>
            </action>
        </referenceBlock>
    </body>
</page>