>WP_004082808.1 reverse gyrase [Thermotoga maritima]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LPE-D-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--EFWNEYEDFRSFFKKKF-GKDL---YEK-------------YVTEETTRRLEEIMDKV-ERGEED--YQATLRLLY---EEI-----------------------------------------------------------------KSLMEEG-------------------------------------------------------
>WP_008193954.1 MULTISPECIES: reverse gyrase [Thermotoga]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LPE-D-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--EFWNEYEDFRSFFKKKF-GKDL---YEK-------------YVTEETTRRLEEIMDKV-ERGEKD--YQATLRLLY---EEI-----------------------------------------------------------------KSLMEEG-------------------------------------------------------
>WP_038033294.1 MULTISPECIES: reverse gyrase [Thermotoga]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LLE-E-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--DFWNEYEDFRSFFKKKF-RKDL---YEK-------------YVTEETTRRLEEIMDKV-ERGEED--YQATLRLLY---EEI-----------------------------------------------------------------KSLMEEG-------------------------------------------------------
>WP_012310746.1 reverse gyrase [Thermotoga sp. RQ2]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LLE-E-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--DFWNEYEDFRSFFKKKF-GKDL---YEK-------------YVTEETTRRLEEIMDKV-ERGEED--YQATLRLLY---EEI-----------------------------------------------------------------KSLMEEG-------------------------------------------------------
>AJF34550.1 reverse gyrase [Thermotoga sp. TBXY761]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LLE-E-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--DFWNEYEDFRSFFKKKF-RKDL---YEK-------------YVTEETTRRLEEIMDKV-ERGEED--YQATLRLLY---EEI-----------------------------------------------------------------KSLMEEG-------------------------------------------------------
>AJA38645.1 reverse gyrase [Thermotoga sp. TBYP3.1.4.1]
----------------------------------------------------------------------------M-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LLE-E-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--DFWNEYEDFRSFFKKKF-RKDL---YEK-------------YVTEETTRRLEEIMDKV-ERGEED--YQATLRLLY---EEI-----------------------------------------------------------------KSLMEEG-------------------------------------------------------
>WP_011943348.1 reverse gyrase [Thermotoga petrophila]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LPE-E-----------------------------SPSD----IYGALLERKTL-------K----EYR-FYH--EFWNEYEDFRSFFKKKF-GKDL---YEK-------------YVTEETTRRLEEIMDKV-ERGEED--YQATLRLLY---EEI-----------------------------------------------------------------KSLMEEG-------------------------------------------------------
>AIY88087.1 reverse gyrase [Thermotoga sp. Cell2]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LLE-E-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--DFWNEYEDFRSFFKKKF-RKDL------------------------------------------------LLRLL--------------------------------------------------------------------------LWKK--------------------------------------------------------
>WP_012896154.1 reverse gyrase [Thermotoga naphthophila]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LLE-E-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--DFWNEYEDFRSFFKKKF-GKDL---YEK-------------YVTEETTRRLEEIMDKV-ERGEED--YQATLRLLY---EEI-----------------------------------------------------------------KSLMEEG-------------------------------------------------------
>HBU00097.1 reverse gyrase [Thermotoga naphthophila]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YEK-------------YVTEETTRRLEEIMDKV-ERGEED--YQATLRLLY---EEI-----------------------------------------------------------------KSLMEEG-------------------------------------------------------
>KHC93356.1 reverse gyrase [Thermotoga sp. Mc24]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LPE-E-----------------------------SPSD----IYGALLERKTL-------K----EYR-FYH--EFWNEYEDFRSFFKKKF-GKDL------------------------------------------------LLRLL--------------------------------------------------------------------------LWKK--------------------------------------------------------
>WP_101512579.1 reverse gyrase [Thermotoga sp. SG1]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGVNTD-ERNERGLPCEVC-LPE-E-----------------------------SPFD----IYEALLERRTL-------K----DYR-FYH--RFWNEYEDFRNFFKKMF-GKNL---YER-------------FVTEETTRRLEEIMDRV-EKGEED--YQSTLRLLY---EEI-----------------------------------------------------------------KSLTEEG-------------------------------------------------------
>WP_041844072.1 reverse gyrase [Thermotoga sp. RQ7]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------LKYHHSCINCRGVNTD-ERNERGLPCEVC-LPE-E-----------------------------SPSD----IYEALLERRTL-------K----DYR-FYH--RFWSEYEDFRNFFKEMF-GKNL---YER-------------FVTEETTRRLEEIMDRV-EKGEED--YQSTLRLLY---EEI-----------------------------------------------------------------KSLTEEG-------------------------------------------------------
>WP_015919009.1 reverse gyrase [Thermotoga neapolitana]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------LKYHHSCINCRGVNTD-ERNERGLPCEVC-LPE-E-----------------------------SPSD----IYEALLERRTL-------K----DYR-FYH--RFWREYEDFRNFFKEMF-GKNL---YER-------------FVTEETTRRLEEIMDRV-EKGEED--YQSTLRLLY---EEI-----------------------------------------------------------------KSLTEEG-------------------------------------------------------
>CAI44249.1 reverse gyrase [Thermotoga neapolitana LA10]
-------------------------------------MHERENR-----------------QP-DRKTKEVSGELAV-------------------------------------N-------------------------------------------------LKYHHSCINCRGVNTD-ERNERGLPCEVC-LPE-E-----------------------------SPSD----IYEALLERRTL-------K----DYR-FYH--RFWREYEDFRNFFKEMF-GKNL---YER-------------FVTEETTRRLEEIMDRV-EKGEED--YQSTLRLLY---EEI-----------------------------------------------------------------KSLTEEG-------------------------------------------------------
>WP_101511143.1 reverse gyrase [Thermotoga sp. KOL6]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCNGVNTD-ERNERGLPCEIC-LPG-E-----------------------------SPSD----IYNELLTRGTL-------K----DYR-FYH--DFWNRYEEFRNFFKKSF-GKDL---YEK-------------YVTEDTTRRLEEIMDRV-EKGLED--YQATLRFLY---EEI-----------------------------------------------------------------KSLMEEG-------------------------------------------------------
>PMQ01653.1 reverse gyrase [Dictyoglomus sp. NZ13-RE01]
--------------------------------------------------------------------------MAI-------------------------------------G-------------------------------------------------AKYYHSCVNCGDINTD-HRNEKGLPCEKC-LPT-EG-----------------------------TDN----LLHDLEKFNTL-------K----DYL-FYS--NFYSQYEEFLKFFEKKF-GKPL---YRD-------------YIVEETTRDLEKLMEIV-EKGEKD--YQEVLSSLY---SDL-----------------------------------------------------------------QKLMRE--------------------------------------------------------
>WP_011917108.1 reverse gyrase [Caldicellulosiruptor saccharolyticus]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINSD-TRNQKGLPCEKC-LPF-EN-----------------------------NMN----ILESLKEHNSL-------K----DYA-YFW--NFQNEYKEFEKFFVSKV-GKPM---YQD-------------YINEETTRDLERLMEVV-EIGEKD--YQSVLSSLY---EEL-----------------------------------------------------------------TKIMQR--------------------------------------------------------
>WP_039764098.1 reverse gyrase [Caldicellulosiruptor sp. F32]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINSD-TRNQKGLPCEKC-LPF-EN-----------------------------NMN----ILESLKEHNSL-------K----DYA-YFW--NFKNEYKEFEKFFVSKV-GKPM---YQD-------------YINEETTRDLERLMEIV-EMGEKD--YQSVLNSLY---EEL-----------------------------------------------------------------TKIMQR--------------------------------------------------------
>WP_045165808.1 reverse gyrase [Caldicellulosiruptor naganoensis]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINSD-TRNQKGLPCEKC-LPF-EN-----------------------------SMN----ILESLKQHNSL-------K----DYA-YFW--NFQNEYKEFEKFFVSKV-GKPM---YQD-------------YINEETTRNLERLMEVV-EMGEKD--YQNVLSSLY---EEL-----------------------------------------------------------------TKIIQS--------------------------------------------------------
>WP_127352095.1 reverse gyrase [Caldicellulosiruptor changbaiensis]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINSD-TRNQKGLPCEKC-LPF-EN-----------------------------GMN----ILESLKQYNSL-------K----DYA-YFW--NFQNEYKEFEDFFVSKV-GKPM---YQD-------------YINEETTRDLERLMEVV-EMGEKD--YQNVLSSLY---EEL-----------------------------------------------------------------TKIIQS--------------------------------------------------------
>WP_045174597.1 reverse gyrase [Caldicellulosiruptor danielii]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINSD-TRNQKGLPCEKC-LPS-EN-----------------------------GES----IFESLKQTHNL-------K----DYA-HLW--KFQNEYKEFEKFFISTV-GKPM---YQD-------------YINEETTRDLEKLMEVV-EMGEKD--YQNVLSSLY---EDL-----------------------------------------------------------------TKIMQR--------------------------------------------------------
>RKX56552.1 reverse gyrase [Thermotoga sp.]
--------------------------------------------------------------------------MAV-------------------------------------G-------------------------------------------------LRYHHSCVNCFGLNTD-ERNEKGLPCEVC-LSE-EV----------------------------EPEE----VLQRLEKNGKL-------M----FYR-YIK--DFEKNFSDFSDFFKRVT-GFPP---YNR-------------FVTEETTRKLEKLMDEI-ENGEKD--HQEALKGFF---EEL-----------------------------------------------------------------KNIMEEV-------------------------------------------------------
>OQX58454.1 reverse gyrase [Thermotoga sp. 4484_232]
--------------------------------------------------------------------------MAV-------------------------------------G-------------------------------------------------LRYHHSCVNCFGLNTD-ERNEKGLPCEVC-LSE-EV----------------------------EPGE----VLQRLEKNGKL-------M----FYR-YIK--DFEKNFSDFSDFFKRVT-GFPP---YNR-------------FVTEETTRKLEKLMDEI-ENGEKD--HQEALKGFF---EEL-----------------------------------------------------------------KNIMEEV-------------------------------------------------------
>WP_045169780.1 reverse gyrase [Caldicellulosiruptor morganii]
--------------------------------------------------------------------------MST-------------------------------------G-------------------------------------------------AKYYHSCINCGGINSD-TRNQKGLPCEKC-LPS-EE------------------------------EN----ILEYLTQTHNL-------K----DYA-NFL--AFQNEYREFEKFFVSTV-GKPM---YQD-------------YVNEETTRELEKLMEVV-ETGEKD--YQQVLRSLY---KEF-----------------------------------------------------------------TEIISK--------------------------------------------------------
>WP_029228260.1 reverse gyrase [Caldicellulosiruptor acetigenus]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEQC-LSQ-EQ----------------------------ISKN----IFESLKKKGTL-------K----DYQ-IYW--NFQQNFDTFEKFFEHIF-QKPL---YGE-------------YVNEQTTRELEKLMDIV-EEGKRD--YQEILSELF---NDL-----------------------------------------------------------------KNLIEN--------------------------------------------------------
>WP_013432424.1 reverse gyrase [Caldicellulosiruptor kristjanssonii]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-IRNENGLPCEQC-LSQ-EQ----------------------------IN-D----IYESLKKMGTL-------K----DYR-LYW--NFQQNFDMFEKFFEHIF-QKPL---YGE-------------YVNEQTTRELEKLMDIV-EEGKRD--YQEVLQELY---NDI-----------------------------------------------------------------SALVND--------------------------------------------------------
>RKX49397.1 reverse gyrase, partial [Thermotogae bacterium]
--------------------------------------------------------------------------MAV-------------------------------------G-------------------------------------------------LRYHHSCVNCFGLNTD-ERNEKGLPCEVC-LSE-EV----------------------------EPEE----VLQRLEKNGKL-------M----FYR-YIK--DFEKNFSDFSDFFKRVT-GFPP---YNR-------------FVTEETTRKLEKLMDEI-ENGEK-------------------------------------------------------------------------------------------------------------------------------------------------
>WP_014042100.1 reverse gyrase [Caldicellulosiruptor lactoaceticus]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEQC-LSQ-EQ----------------------------ISKN----IFESLKKKGTL-------K----DYQ-IYW--NFQQNFDTFEKFFEHIF-QKPL---YGE-------------YVNEQTTRELEKLMDIV-EEGKRD--YQEILSELF---NDL-----------------------------------------------------------------KNLIEN--------------------------------------------------------
>WP_013430517.1 reverse gyrase [Caldicellulosiruptor kronotskyensis]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEKC-LKD-DH----------------------------LTEN----VFELLKGCGLL-------K----DYQ-IYW--NFHQNYKMFEKFFELIF-HKPM---YGE-------------YVNEQTTRELEKLMDIV-EEGKRD--YQEVLQELY---NDI-----------------------------------------------------------------SVLLNK--------------------------------------------------------
>WP_013411901.1 reverse gyrase [Caldicellulosiruptor owensensis]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEKC-LED-DH----------------------------LTEN----VFELLKGRGLL-------K----DYQ-IYW--NFHQSYKMFEKFFELIF-HKPM---YGE-------------YVNEQTTRELEKLMDIV-EEGKRD--YQEILSELF---NDL-----------------------------------------------------------------KNLLEN--------------------------------------------------------
>WP_022587101.1 reverse gyrase [Caldanaerobacter subterraneus]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEVC-LPF-ED------------------------------GD----ILKGLKLNNSL-------K----GYE-KYW--NLNQQYKEFEEFFFSKI-NKKP---YMN-------------YINEETTRQLEKLMESV-ETGEKD--YQSVLKNLY---EEL-----------------------------------------------------------------NEILIKN-------------------------------------------------------
>KUK08414.1 Reverse gyrase [Caldanaerobacter subterraneus]
------------------------------------------------------------------------MALAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEVC-LPF-ED------------------------------GD----ILKGLKLNNSL-------K----GYE-KYW--NLNQQYKEFEEFFFSKI-NKKP---YMN-------------YINEETTRQLEKLMESV-ETGEKD--YQSVLKNLY---EEL-----------------------------------------------------------------NEILIKN-------------------------------------------------------
>WP_015907632.1 reverse gyrase [Caldicellulosiruptor bescii]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCSGINTD-TRNEKGLPCEKC-LKD-DH----------------------------LTEN----VFELLKGRGLL-------K----DYQ-IYW--NFHQNYKMFEKFFEHIF-QKPL---YGE-------------YVNEQTTRELEKLMDIV-EEGKRD--YQEVLLELY---NDI-----------------------------------------------------------------SVLLNN--------------------------------------------------------
>PBD03988.1 reverse gyrase [Caldicellulosiruptor bescii]
-------------------------------------------------------------------------MLAT-------------------------------------G-------------------------------------------------AKYYHSCINCSGINTD-TRNEKGLPCEKC-LKD-DH----------------------------LTEN----VFELLKGRGLL-------K----DYQ-IYW--NFHQNYKMFEKFFEHIF-QKPL---YGE-------------YVNEQTTRELEKLMDIV-EEGKRD--YQEVLLELY---NDI-----------------------------------------------------------------SVLLNN--------------------------------------------------------
>WP_132040153.1 reverse gyrase [Caldanaerobacter subterraneus]
------------------------------------------------------------------------MALAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEVC-LPF-ED------------------------------GD----ILKGLKLNNSL-------K----GYE-KYW--NLNQQYKEFEEFFFSKI-NKKP---YMN-------------YINEETTRQLEKLMESV-ETGEKD--YQSVLKNLY---EEL-----------------------------------------------------------------NEILIKN-------------------------------------------------------
>WP_011025941.1 reverse gyrase [Caldanaerobacter subterraneus]
------------------------------------------------------------------------MALAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEVC-LPF-ED------------------------------GD----VLKGLKLNNSL-------K----GYE-KYW--NLNQQYKEFEEFFFSKI-NKKP---YMN-------------YINEETTRQLEKLMESV-ETGEKD--YQSVLKNLY---EEL-----------------------------------------------------------------NEILIKN-------------------------------------------------------
>WP_013403483.1 reverse gyrase [Caldicellulosiruptor hydrothermalis]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNEKGLPCEEC-LAQ-EQ----------------------------LNEN----IFESLKKKGSL-------K----HYQ-LYW--NFQQIYSMFEKFFELIF-HKPM---YGE-------------YVNEQTTRELEKLMDIV-EEGKRD--YQEILQELY---NDI-----------------------------------------------------------------SVLLNK--------------------------------------------------------
>WP_013290690.1 reverse gyrase [Caldicellulosiruptor obsidiansis]
--------------------------------------------------------------------------MAT-------------------------------------G-------------------------------------------------AKYYHSCINCGGINTD-TRNENGLPCEQC-LSQ-KQ----------------------------IN-D----IYKSLKKMGTL-------K----DYQ-LYW--NFQQNLNAFKMFFEHIF-QKPL---YGE-------------YVNEQTTRELEKLMDIV-EEGKRD--YQEILQELY---NDI-----------------------------------------------------------------SELLNK--------------------------------------------------------
>PFH15103.1 reverse gyrase [Caldicellulosiruptor bescii]
-------------------------------------------------------------------------MLAT-------------------------------------G-------------------------------------------------AKYYHSCINCSGINTD-TRNEKGLPCEKC-LKD-DH----------------------------LTEN----VFELLKGRGLL-------K----DYQ-IYW--NFHQNYKMFEKFFEHIF-QKPL---YGE-------------YVNEQTT--------LV-------------------------------------------------------------------------------------------------------------------------------------------------------
>WP_012579357.1 reverse gyrase [Thermosipho africanus]
--------------------------------------------------------------------------MPV-------------------------------------N-------------------------------------------------LKFDHSCINCEKINTD-DRNLKGLPCIKC-LPN-E------------------------------TND----YINSLITTNKL-------Y----KLE-KYI--RFENEFKDFFNFFVEKT-GLKL---YNK-------------FINEETTRTLEKIMDEV-EKGIKE--FQQTLHEIY---NEI-----------------------------------------------------------------KGGIK---------------------------------------------------------
>WP_126993991.1 reverse gyrase [Thermosipho globiformans]
--------------------------------------------------------------------------MPV-------------------------------------N-------------------------------------------------LKFDHSCINCEKINTD-DRNLKGLPCIEC-LPN-E------------------------------TND----YINSLITTNKL-------Y----KLE-KYI--RFENEFKDFFNFFVEKT-GLKP---YNK-------------FINEETTRTLEKIMDEV-EKGRKE--FQQTLHEIY---NEI-----------------------------------------------------------------KGGIK---------------------------------------------------------
>WP_073072845.1 reverse gyrase [Thermosipho atlanticus]
--------------------------------------------------------------------------MPL-------------------------------------G-------------------------------------------------LKYYHTCINCEGVNTD-NRNLKGLPCEKC-LPK-V------------------------------PKD----FEKTLKLNGKL-------Q----KLS-TYI--KFQKSFEDFKKFFGEKV-GSTL---YQK-------------FITEETTRNLELIMDEV-ERGERE--YQMVLKEMY---EEI-----------------------------------------------------------------RGGGYE--------------------------------------------------------
>RKX39946.1 reverse gyrase, partial [Thermotogae bacterium]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YNR-------------FVTEETTRKLEKLMDEI-ENGEKD--HQEALKGFF---EEL-----------------------------------------------------------------KNIMEEV-------------------------------------------------------
>HAA82695.1 reverse gyrase [Thermotoga naphthophila]
--------------------------------------------------------------------------MAV-------------------------------------N-------------------------------------------------SKYHHSCINCGGLNTD-ERNERGLPCEVC-LLE-E-----------------------------SPSD----IYRALLERKTL-------K----EYR-FYH--DFWNEYEDFRSFFKKKF-GKDL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>HCF37691.1 reverse gyrase [Thermosipho africanus]
--------------------------------------------------------------------------MPV-------------------------------------N-------------------------------------------------LKFDHSCINCEKINTD-DRNLKGLPCIKC-LPN-E------------------------------TND----YINSLITTNKL-------Y----KLE-KYI--RFENEFKDFFNFFVEKT-GLKL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>RLF25233.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------------MH----------------------------------------------------------------------------------------AIFEGLCPNCGGEIAD-DRLMMCLPCRRC-LPD-DKAQ-ELIK-LY--GK---------IPLLEFKKK----VVEYLGK--NL-------K----NYV-KVV--ELDEKLKDVDLLFHKAT-GSYL---YKT-------------LVSEERTRKLEELMDKI-ELGQED--YQKVIKELY---EEM-K----------------------------------------------------------------SFARV----------------------------------------GYD-------------
>RLE54014.1 reverse gyrase [Candidatus Verstraetearchaeota archaeon]
--------------------------------------------------------------------MINE--IH----------------------------------------------------------------------------------------GIYGHACPNCGGREED-LRLLMKLPCSRC-LP--K-IP-DKGR----------------L----SIDE----IYEILKRSGRV-------K----NYG-RIY--EFERKYREFEKLFRKAT-GSRP---YSD-------------LVSEERTRMLEEIMDSI-ERGEAE--YLEILRNLH---EEI-M----------------------------------------------------------------KITN---------------------------------------------------------
>WP_012571288.1 reverse gyrase [Thermococcus onnurineus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AVYREMCPNCLGRISD-ERLCLKNPCNEC-L-----DE-TAHA----------------DSYFELITA----VRNALQLKGTL-------K----EWE-RIY--ELESGVREVEAFFENAT-GFTF---YKE-------------LVGEEKTRELEEIMDMI-EENKTD--YQEVLRGLY---SEI-R----------------------------------------------------------------EYLK---------------------------------------------------------
>WP_015859292.1 reverse gyrase [Thermococcus gammatolerans]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------ALYREMCPNCGGRISD-ERLYMRNPCESC-L-----NE-PIVV----------------DSYFELVSA----VRDALLKANRL-------K----EWE-RIY--RLESESREIEDFFKKAT-GFTF---YRE-------------LVSEEKTRELEEKMDLI-EEGKLN--YLDVLNELY---REI-T----------------------------------------------------------------CEIKKEG------CS----------------------------------------------
>WP_099210150.1 reverse gyrase [Thermococcus sp. EXT12c]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREACPNCSGRISD-ERLVMKNPCDEC-L-----DN-PVTA----------------EDYFELVKA----VRKALKERKKL-------K----AWE-EIY--SLEKGLRDVEKFFEKAT-GFTF---YRE-------------LVSEERTRELEKLMDLI-EEGKVD--YTGVLNDLY---AEI-R----------------------------------------------------------------RYVYGEG------------------------------------------------------
>RLE51953.1 reverse gyrase [Candidatus Verstraetearchaeota archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIFENACPNCGGPIDD-ERLMLAAPCRNC-LDI-P-DE-QLKQ-LMSS------------NLLDYRKK----IVELLEQRGTL-------Q----KYA-EVE--LFEREIADFKEMAKKAL-GVDL---FGD-------------MVSEERTRIVEEKMDLI-ERGELD--YQRVLSEFY---EEI-K----------------------------------------------------------------QLPPEIE------A----MPMA---------------------------------------
>WP_042689032.1 reverse gyrase [Thermococcus nautili]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREACPNCSGRISD-ERLVMKNPCDEC-L-----DN-PVTA----------------EDYFELVKA----VREALKERKKL-------K----AWE-EIY--SLEKGLRDVEKFFEEAT-GFRF---YRE-------------LVSEERTRELEKLMDLI-EEGKAD--YMKVLNDLY---VEI-R----------------------------------------------------------------RYVYGEG------------------------------------------------------
>RLE49788.1 reverse gyrase [Candidatus Verstraetearchaeota archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIFENACPNCGGPIDD-ERLMLSAPCRNC-LDI-P-DE-QLKQ-LMSS------------NLLDYRKK----IVELLEQKGTL-------Q----KYA-EVE--LFEREVADFKETAKKAL-GVDL---FGD-------------MVSEERTRIVEEKMDLI-ERGELD--YQRVLSEFY---EEI-K----------------------------------------------------------------QLPPEIE------A----MPMA---------------------------------------
>WP_068666330.1 reverse gyrase [Thermococcus piezophilus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AVYREMCPNCVGRISD-ERLCSKNPCDEC-L-----PE-AVHA----------------NSYLELVTA----VRNALKLRGTL-------K----AWE-ELY--QVESQTHEIEEFFEKAT-GFTF---YKE-------------LVSEEKTRELEEIMDQI-EENKVD--YQTVLRQLY---SEI-Q----------------------------------------------------------------EYLK---------------------------------------------------------
>WP_058946101.1 reverse gyrase [Thermococcus sp. 2319x1]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCEGSISD-LRLYRKHPCEVC-L-----DE-EIKA----------------EVYFDLIKG----IRDALKLRGTL-------K----YWE-ELY--SLEKKLNEAEELFKKAT-GFTF---YKE-------------LVSEERTRQLEELMDLV-EENKVD--YQEVLNDMY---EEI-R----------------------------------------------------------------KYIA---------------------------------------------------------
>WP_013748907.1 reverse gyrase [Pyrococcus sp. NA2]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCGGAITD-ERLSSKNPCEGC-L-----AE-PIVL----------------QDYDKLIEA----IRNALKLRDTL-------K----DWE-ELY--RLNKEVSEVEELFERAT-GFRF---YKP-------------LVNEERTRQLEKIMDMV-EEAKAD--YQDVLNELY---DEI-K----------------------------------------------------------------AYVK---------------------------------------------------------
>WP_062387477.1 reverse gyrase [Thermococcus peptonophilus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCWGRISD-ERLLMRNPCDEC-L-----DE-PVHA----------------DSYFQLVSA----VRNALKLRGTL-------K----EWE-RIY--QLENQTREIEEFFRKAT-GFTF---YRD-------------LVSEERTRELEEIMDRI-EEGVED--YLEVLHELY---LEI-Q----------------------------------------------------------------RYVAG--------------------------------------------------------
>WP_088884595.1 reverse gyrase [Thermococcus gorgonarius]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCEGRISD-DRLVMKNPCKEC-L-----DE-PVHA----------------DSYFQLVSA----VRNALKLRGTL-------K----EWE-RIY--QLESNTREIEELFNKAT-GFTF---YRD-------------LVSEERTRELEEIMDRI-EEGKED--YQEVLNGLY---SEI-T----------------------------------------------------------------EFIGKA-------------------------------------------------------
>WP_013905419.1 reverse gyrase [Pyrococcus yayanosii]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCEGRISD-ERLSMKNPCESC-L-----DE-PVGE----------------QVYFDLIKA----VRDALKLKGTL-------K----EWE-EIY--KLNKAVKDVEKFFEKAT-GFTF---YKD-------------LVSEERTRQLEELMDMV-EEARAD--YQEVLNDLY---KEI-Q----------------------------------------------------------------TYVR---------------------------------------------------------
>WP_088180063.1 reverse gyrase [Thermococcus sp. 5-4]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCLGKISD-ERLYLKNPCNEC-L-----DE-TAHA----------------DSYFDLVTA----VRNALQLRGTL-------K----EWE-RIY--GLEKGLREIEAFFEKAT-GFTF---YKE-------------LVSEEKTRELEEIMDLI-EENKID--YQEVLRKLH---GEI-R----------------------------------------------------------------QYLG---------------------------------------------------------
>RLE61660.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------VIYDLSCPNCKGRNEY-DRIYLGVPCSSC-LPL-S-IE-KIKELRRTC-----------ESDIEFRRR----VYDMLKQYGTL-------K----YYE-DIV--KFDEKINDFSRFFEKAL-GNRP---YED-------------LISEERTRIVERKMQMI-EEGKAD--YREVLEDFY---EEI-S----------------------------------------------------------------KIAS---------------------------------------------------------
>AAB49283.1 reverse gyrase [Pyrococcus furiosus DSM 3638]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRDMCPNCRGAITD-ERLAAKNPCDAC-L-----DE-PISM----------------DDYFQLVTA----IRKALKLKGVL-------K----EWE-EIY--ALNKEVKEIEELFKKAT-GFTF---YKD-------------LVSEERTRQLEKLMDMV-EEAKAN--YQEVLNELY---EEI-L----------------------------------------------------------------RYVKS--------------------------------------------------------
>WP_050003023.1 reverse gyrase [Thermococcus eurythermalis]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------ALYREMCPNCSGRISD-ERLVMKNPCDDC-I-----DN-PVTA----------------ESYFELVNA----VREALKSRGKL-------K----AWE-DIY--SLEKGLREIEEFFEKAT-GFTF---YRD-------------LVSEERTRELEKLMDQI-EEGKAD--YIEVLNDLY---SEL-R----------------------------------------------------------------RYVYGEG------------------------------------------------------
>WP_011011612.1 reverse gyrase [Pyrococcus furiosus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRDMCPNCRGAITD-ERLAAKNPCDAC-L-----DE-PISM----------------DDYFQLVTA----IRKALKLKGVL-------K----EWE-EIY--ALNKEVKEIEELFKKAT-GFTF---YKD-------------LVSEERTRQLEKLMDMV-EEAKAN--YQEVLNELY---EEI-L----------------------------------------------------------------RYVKS--------------------------------------------------------
>WP_068577684.1 reverse gyrase [Thermococcus chitonophagus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCNGAITD-NRLANKNPCDAC-L-----DE-PEVH----------------EDYFELITA----IRNALKLRGTL-------K----EWE-KIY--RLNKEVKDVEEFFKKAT-GFTF---YRD-------------LVSEERTRQLEKIMDEI-EEAKVN--YQDVLNELY---EEI-K----------------------------------------------------------------RYVASS-------------------------------------------------------
>WP_010868381.1 reverse gyrase [Pyrococcus abyssi]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCGGAITD-ERLAEKNPCEGC-L-----SE-PIKA----------------EDYEKLVFA----VRNALKLRGTL-------K----DWE-DLY--RLNKEVSEVEDLFKRAT-GFRF---YKD-------------LVSEERTRQLEKIMDEI-EEAKAD--YQEVLRELH---EEI-K----------------------------------------------------------------RYIRS--------------------------------------------------------
>RLE60657.1 reverse gyrase [Thermoprotei archaeon]
-----------------------------MDIFPYKVVN-----------------------------------VR----------------------------------------------------------------------------------------AFLQGMCPNCEGRITD-ERLVNRLPCRKC-LRD----S-QIGE-LCYRDKS-------VEDYYQWLIQ----VEKLLKRNDTL-------K----AYK-NIV--ELEREVEMYNRFFKKIV-GNNL---FPS-------------LVSEDRTRIVEEIMDKI-ESGEIN--YLHALEDFY---EEI-R----------------------------------------------------------------SVEEKE-------------------------------------------------------
>KUJ99632.1 Reverse gyrase [Thermococcales archaeon 44_46]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCEDRISD-SRLYKKHPCEVC-L-----DE-EIKA----------------EVYFDLIKG----IRDALKLKGTL-------K----HWE-ELY--SLEKKLNEAEELFKKAT-GFTF---YKE-------------LVSEERTRQLEELMDLV-EKNKVD--YQEILNDMY---KEI-R----------------------------------------------------------------KYIAS--------------------------------------------------------
>WP_088866544.1 reverse gyrase [Thermococcus radiotolerans]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCLGKISD-ERLYLKNPCNEC-L-----DE-TAHA----------------DSYFDLVTA----VRNALQLRGTL-------K----EWE-RIY--GLEKGLREIEAFFEKAT-GFTF---YKE-------------LVSEEKTRELEEIMDLI-EENKID--YQEVLRKLH---GEI-R----------------------------------------------------------------QYLG---------------------------------------------------------
>WP_088882843.1 reverse gyrase [Thermococcus sp. P6]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCLDRISD-ERLYMKNPCKEC-L-----DE-PLHA----------------DSYFDLVSA----VRNALKLRGTL-------K----EWE-RIY--SLEKDLREIEEFFRRAT-GFTF---YRD-------------LVSEEKTRELEEIMDRI-EEGKAD--YEEVLGGLY---EEI-Q----------------------------------------------------------------KFLT---------------------------------------------------------
>WP_042697994.1 reverse gyrase [Thermococcus sp. PK]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCEDRISD-SRLYKKHPCEVC-L-----DE-EIKA----------------EVYFDLIKG----IRDALKLKGTL-------K----HWE-ELY--SLERKLKEAEELFEKAT-GFTF---YKE-------------LVSEERTRQLEELMDLV-EENKVD--YQEILNDMY---KEI-R----------------------------------------------------------------KYIAS--------------------------------------------------------
>RLG75806.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------MISE--PH----------------------------------------------------------------------------------------GIYRHGCINCSGEISD-LRLSYMLPCEKC-LPI-R-VE-DLIK----------------AMPSPTHTD----IIKLTEKLGTL-------K----KLR-KLK--YIISEVNEFHRLFEKLI-GNKM---YSR-------------LVSEERTAMLEELMDEI-ERGEKN--YLDVLDELY---DEI-T----------------------------------------------------------------SLP----------------------------------------------------------
>WP_014733806.1 reverse gyrase [Pyrococcus sp. ST04]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCNGAITD-ERLASKNPCDAC-L-----DK-PEIS----------------ENYFDLVTA----VRNALKLRGTL-------K----HWE-ELY--KLNKEVKEVEDLFKKAT-GFTF---YKD-------------LVSEERTRQLESIMDAI-EEARAN--YQDVLNDLY---EEI-R----------------------------------------------------------------RYVNKS-------------------------------------------------------
>OYT50813.1 reverse gyrase [Candidatus Bathyarchaeota archaeon ex4484_135]
--------------------------------------------------------------------------MR----------------------------------------------------------------------------------------AVFERSCPNCGGRISD-IRLLMGIPCDKC-LPL-P-DE-ELSE-KLKG-----------LSKEEAMIF----CLEKLKELGTL-------K----HYA-SLV--EFHRKVADFEAFFEKAL-GCPP---FEQ-------------YVSEETTRRLEEAMKAV-EEGKAD--YMEILRDLY---REI-R----------------------------------------------------------------AISL---------------------------------------------------------
>WP_013413183.1 reverse gyrase [Methanothermus fervidus]
-------------------------------------------------------------------------MYR----------------------------------------------------------------------------------------AIYKGMCPNCGKEIDD-SRLNAKNPCKSC-V-----EK-KLQC----------------EDYHELLEK----IEEYLKENNNL-------Y----GWK-EIY--ELHRDLKDIENLFEKAT-NSKF---YEK-------------LVSEERTRELEKVMDEI-EEGSRN--YQEVLNSIY---EEI-K----------------------------------------------------------------QFV----------------------------------------------------------
>WP_068321043.1 reverse gyrase [Pyrococcus kukulkanii]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCRGAITD-DRLASKNPCDAC-L-----DE-PEVH----------------EDYFKLITA----VRNALKLRGTL-------K----EWE-EVY--RLNKEVKDVEEFFKKAT-GFTF---YKD-------------LVSEERTRQLEKIMDEI-EEAKAN--YQEVLNELY---EEI-R----------------------------------------------------------------RYVTSS-------------------------------------------------------
>WP_004068124.1 reverse gyrase [Thermococcus litoralis]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCEDRIGD-LRLYKKHPCEVC-L-----DE-EIKA----------------EVYFDLIKG----IRDALKLRGTL-------K----HWE-ELY--SLEKKLNEAEELFKKAT-GFTF---YKE-------------LVSEERTRQLEELMDLV-EENKID--YQEVLNDMY---EEI-R----------------------------------------------------------------KYIA---------------------------------------------------------
>WP_088864286.1 reverse gyrase [Thermococcus barossii]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCLGKISD-ERLYLKNPCDEC-L-----DE-TVWT----------------DSYFDLVTA----VRNALQLRGTL-------K----EWE-RIY--GLEKGVREIEEFFERAT-GFTF---YKE-------------LVSEEKTRELEEIMDLV-EENKMD--YQEVLRRLH---GEI-R----------------------------------------------------------------RYLG---------------------------------------------------------
>WP_014788222.1 reverse gyrase [Thermococcus cleftensis]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCAGRISD-ERLVMKNPCDEC-L-----ES-PVHA----------------DSYFELITA----VRNALQLRGTL-------K----EWE-RIH--SLEAGLREVEEFFEKAT-GFTF---YKE-------------LVSEEKTRELEELMDRI-EEKGVD--YQKVLGGLY---REL-Q----------------------------------------------------------------EYLKGGN------EGSV--------------------------------------------
>RLF20142.1 reverse gyrase [Thermoprotei archaeon]
---------------------------------------------------------------------MKLPTVR----------------------------------------------------------------------------------------AIFRRACPNCGGEITD-ERLWLMLPCERC-LPP-DEAE-KLVK-LYYSSK---------LTPLEFKLE----VFRKLKELGNL-------K----DYR-KVV--ELDILLKELDELFEKAI-GSKL---YKD-------------LVSEDRTRLLEELMDAI-EEGLKD--YQDVIRQLY---LEV-T----------------------------------------------------------------DIID---------------------------------------------------------
>RLF87790.1 reverse gyrase [Thermococci archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYRGMCPNCEDRIGD-LRLYKKHPCEVC-L-----DD-EIKA----------------EVYFDLIKG----IRDALKLKGTL-------K----HWE-ELY--SLEKKLNEAEELFKKAT-GFTF---YKE-------------LVSEERTRQLEELMDLV-EENKVD--YQEVLNDMY---REI-G----------------------------------------------------------------KYIA---------------------------------------------------------
>KUK17328.1 Reverse gyrase [Thermococcus sibiricus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYKGMCPNCEDKISD-ERLYKKHPCEIC-L-----ED-EIHS----------------DIYFDLITG----IREGLRVKNRI-------K----HWE-ELY--SLEKKLIEAEELFKNAA-GFTF---YKD-------------LVSEERTRQLEELMDLI-EEDKID--YQEVLSELY---KEI-K----------------------------------------------------------------KYTA---------------------------------------------------------
>WP_088853917.1 reverse gyrase [Thermococcus pacificus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCLGRISD-ERLVEKNPCDEC-L-----DN-PVHS----------------DSYFELVTS----VRNALQVKGTL-------K----EWE-RIY--SLEKNLREVEDFFEKAT-GFTF---YKE-------------LVSEEKTRELEGVMDLI-EENGVN--YQEVLGELY---REI-M----------------------------------------------------------------EHMGVGK------GAAS--------------------------------------------
>KUK28518.1 Reverse gyrase [Thermococcus sp. 40_45]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYKGMCPNCEDKISD-ERLYKKHPCEIC-L-----ED-EIHS----------------DIYFDLITG----IREGLRVKNRI-------K----HWE-ELY--SLEKKLIEAEELFKNAA-GFTF---YKD-------------LVSEERTRQLEELMDLI-EEDKID--YQEVLSELY---KEI-K----------------------------------------------------------------KYTA---------------------------------------------------------
>WP_014012304.1 reverse gyrase [Thermococcus sp. 4557]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCLGRISD-ERLINKNPCSEC-L-----DD-TVTA----------------DSYFDLITA----VRSALKLRGTL-------K----EWE-RIY--SLENGLREVEGFFEKAT-GFTF---YKD-------------LVNEEKTRGLEEMMDRI-EEGSVD--YQEVLNALY---REL-Q----------------------------------------------------------------GYLGNGK------PQ----------------------------------------------
>RLE85948.1 reverse gyrase [Thermoprotei archaeon]
---------MLAWLPNFHALNKKLPDKCTCDSHKFNFVNHQV------------------------RLYREVRILK----------------------------------------------------------------------------------------AIFKNLCPNCKNEIDD-ERLQCKMPCAVC-LPV-S-VE-EYKK-LRNE-----------LKGYEFYKK----IAYELRKFKKL-------K----NYR-DIL--SLEKEVNEVNELFKKIL-GNEM---FYD-------------FISEERTRIVERIMDGI-SEGKID--YQISLKEFY---EEI-S----------------------------------------------------------------KVESA--------------------------------------------------------
>WP_055283293.1 reverse gyrase [Thermococcus sp. EP1]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AVYRGMCPNCQDVISD-ERLYNKHPCETC-L-----DE-EIKS----------------DVYFELVKG----IYDALKLKNTL-------K----HWE-EVY--SLEQRLIEAEKLFKTAT-GFTF---YKE-------------LVSEERTRQLEELMDLI-EENKAN--YQEILNEMY---KEI-K----------------------------------------------------------------KYIA---------------------------------------------------------
>RLE92419.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AKFVNMCPNCGGTISD-ERLELKLPCKQC-LPE-V-PE-KIVQ-ML---KN-------EEPFFAGVSE----VRRLLKERDAL-------K----NYE-EFY--RLEKEVEDANKLFYKAT-GNKL---YKD-------------LVVEERTRYLEEKMDKV-ERGEEN--YLDVLKEFY---QEI-K----------------------------------------------------------------KIEGGS-------------------------------------------------------
>WP_048056247.1 reverse gyrase [Methanocaldococcus fervens]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------MIYKEMCPNCNGEITS-KRLEIGV-CEKC-LKE-EKAF--------------------------EKLK----LCEKLREEKTL-------K----NLK-NYC--NIWNEFKEFEEFVKDL--GFEL---YPN-------------LISEERTRELEEIMDKI-ENGEVD--YLEVLKALH---EEI-----------------------------------------------------------------LSIK----------------------------------------------------------
>RLE77969.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------------MH----------------------------------------------------------------------------------------AAFELMCPNCGGPNTD-DRLILGLPCPKC-LP--D-VE-SLLRARASV-----------TDPLEFKLL----VLEALKRQGTH-------R----MYEAEVV--ALERELRKVNEFFRRAL-GNEP---YSD-------------LVSEGRTRLVERLMDQI-ERGEVD--YQDVLREFY---EEI-A----------------------------------------------------------------PIAG----------------------------------------GG---------------
>ACV23891.1 reverse gyrase [Methanocaldococcus fervens AG86]
---------------------------------------------------------------------MLVLLMIP---------------------------------------------------------------------------------------MIYKEMCPNCNGEITS-KRLEIGV-CEKC-LKE-EKAF--------------------------EKLK----LCEKLREEKTL-------K----NLK-NYC--NIWNEFKEFEEFVKDL--GFEL---YPN-------------LISEERTRELEEIMDKI-ENGEVD--YLEVLKALH---EEI-----------------------------------------------------------------LSIK----------------------------------------------------------
>RLF82021.1 reverse gyrase [Thermococci archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYKGMCPNCGDKISD-ERLYKKHPCEIC-L-----ED-EIHS----------------DIYFDLITG----IREGLRVKNTI-------K----HWE-ELY--SLEKKLIEAEELFKNAT-GFTF---YKD-------------LVSEERTRQLEELMDLI-EEDKID--YQEVLSELY---KEI-K----------------------------------------------------------------KYTA---------------------------------------------------------
>OYT28034.1 reverse gyrase [Thermofilum sp. ex4484_82]
-----------MYL----------------DSHKFNFVNHQV------------------------RLYREVRILK----------------------------------------------------------------------------------------AIFKNLCPNCKNEIDD-ERLQCKMPCAVC-LPV-S-VE-EYKK-LRNE-----------LKGYEFYKK----IAYELRKLKKL-------K----NYR-DIL--FLEKEVNEVNELFKKIL-GNEM---FYD-------------FISEERTRIVERIMDGI-SEGKID--YQISLKEFY---EEI-S----------------------------------------------------------------KVESA--------------------------------------------------------
>RLF86474.1 reverse gyrase [Thermococci archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYKGMCPNCEDKISD-ERLYKKHPCEIC-L-----ED-EIHS----------------DIYFDLITG----IREGLRVKNTI-------K----HWE-ELY--SLEKKLIEAEELFKNAT-GFTF---YKD-------------LVSEERTRQLEELMDLI-EEDKID--YQEVLSELY---KEI-K----------------------------------------------------------------KYTA---------------------------------------------------------
>WP_013467038.1 reverse gyrase [Thermococcus barophilus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCEDRISD-ERLYKKHPCDVC-L-----DR-EIQA----------------EIYFDLITG----IREALKLRRTL-------K----HWE-NIY--KLEKKLREIEDLFEKAT-GFNF---YKE-------------LVSEERTRQLEELMDLV-EENKAD--YQEVLSNMY---EEI-K----------------------------------------------------------------QYILK--------------------------------------------------------
>WP_056933692.1 reverse gyrase [Thermococcus barophilus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCEDRISD-ERLYKKHPCDVC-L-----DR-EIQA----------------EIYFDLIMG----IREALKLRGTL-------K----HWE-NIY--KLEKKLREIEDLFEKAT-GFNF---YKE-------------LVSEERTRQLEELMDLV-EENKAD--YQEVLSNMY---EEI-K----------------------------------------------------------------QYILK--------------------------------------------------------
>WP_048201405.1 reverse gyrase [Methanocaldococcus bathoardescens]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------MIYKEMCPNCSGEITS-ERLEIGV-CEKC-LKE-ENVF--------------------------EKLE----LCEKLREEKTL-------D----NLK-NYC--IIWNEFKEFEEFVKDL--RFEL---YPH-------------LISEERTRELEEIMDKI-ENGEAD--YLEVLKALH---EEI-----------------------------------------------------------------LSIK----------------------------------------------------------
>RLF10985.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------ALFKQACPNCRGDISD-DRLLAGLPCHRC-LDE-EEAA-ELLK-KVEEGQ-------------DLKKL----VLEALEGKGRL-------K----HYA-EVA--KPQFKAEEFNNFFKKAL-GLPL---FGE-------------LVSERRTALLESLMDMI-ERGEAD--YQAILEELY---SEM-K----------------------------------------------------------------HLPR------------------------------------------YA-------------
>WP_048165500.1 reverse gyrase [Palaeococcus pacificus]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AVYREMCPNCEGRISD-ERLVIKHPCENC-L-----DE-KLKT----------------DTYFQLLMG----IREGLKLKGTL-------K----EWE-RLY--QVESELRNVEELFKKAT-GYNF---YRE-------------LVNEEKTRELEAVMDRI-EHGEVN--YQEALSEMY---NEL-R----------------------------------------------------------------RYVL---------------------------------------------------------
>WP_042680401.1 reverse gyrase [Thermococcus paralvinellae]
--------------------------------------------------------------------------MK----------------------------------------------------------------------------------------AIYREMCPNCEDRISD-ERLYKKHPCNVC-L-----DE-EIQA----------------EVYFDLITG----IREALKLKGAL-------K----HWE-EIY--KLEKKLREIEELFEKAT-GFNF---YKE-------------LVSEERTRQLEELMDLV-EENKAD--YQEVLNNMY---TEI-K----------------------------------------------------------------QYILK--------------------------------------------------------
>RLG61061.1 reverse gyrase [Candidatus Geothermarchaeota archaeon]
-----------------------------------------------------------------------MVILK----------------------------------------------------------------------------------------VIFEGLCPNCNGSISD-ERLLLGAPCKQC-LPV-AGRTLKTYS---------------ALPYTSYQVK----IAGLLEKFGTL-------R----EYK-TIS--ELSRAVLEFEELFKKAV-GSKL---FGD-------------ILSERVTRDLERKMDMV-ERG-AD--YQRILLEEY---REI-K----------------------------------------------------------------SLS----------------------------------------------------------
>RLE82433.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------MTE---RH----------------------------------------------------------------------------------------ALFKELCPNCGGEIDD-TRLLLMAPCEKC-LPV-S-NK-ELYS-KMSS-----------MDPLEYKKY----LLKELESGGLL-------K----NYR-QVV--ELDERISEINLMFRKVL-GSNM---YKN-------------LVSENRTRVVEARMKEI-EEGRIS--YQEVLREFF---DEI-V----------------------------------------------------------------RYVT-----------TTYAPSK-------------------M-------------------
>WP_010878524.1 reverse gyrase [Archaeoglobus fulgidus]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------VVYSNLCPVCGGDLES-KEIEKH----VC-FRK-K-------------------------------------------------------R--------SLCLFPEDFLLKEFVEFFRKCV-G-EP---YAK-------------FVSEDRTRDLESRMDAI-ERGELD--YLKALEDLY---AEI-----------------------------------------------------------------KSID----------------------------------------------------------
>YABOI
sdddeeeeeIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII--
>WP_048095487.1 reverse gyrase [Archaeoglobus fulgidus]
--------------------------------------------------------------------------MIP---------------------------------------------------------------------------------------VVYSNLCPVCGGDLES-KEIEKH----VC-FRK-K-------------------------------------------------------R--------SLCLFPEDFLLKEFVEFFRKCV-G-EP---YAK-------------FVSEDRTRDLESRMDAI-ERGELD--YLKALEDLY---AEI-----------------------------------------------------------------KSID----------------------------------------------------------
>RLE81496.1 reverse gyrase [Thermoprotei archaeon]
--------------------------------------------------------------------MTE---RH----------------------------------------------------------------------------------------ALFKELCPNCGGEIDD-TRLLLMAPCEKC-LPV-S-NK-ELYS-KMSS-----------MDPLEYKKY----LLKELESGGLL-------K----NYR-QVV--ELDERISEINLMFRKVL-GSNM---YKN-------------LVSENRTRVVEARMKEI-EEGRIS--YQEVLREFF---DEI-V----------------------------------------------------------------RYVT-----------TTYAPSK-------------------M-------------------
>WP_013100094.1 reverse gyrase [Methanocaldococcus infernus]
-------------------------------------------------------------------------MPVP---------------------------------------------------------------------------------------MIFKEMCPNCGGEISS-ERLTIGV-CENC-LPE-DIRL--------------------------EKLE----LCKKIE----V-------K----NLK-NYC--KVWREFKEFEDFVKSL--GYKL---YPE-------------LISEKRTRELEEIMDKI-ENGEID--YIEVLNELY---KEI-----------------------------------------------------------------LSIT----------------------------------------------------------