Flashcard 1
Question: In contraception, what is progesterone's primary responsibility?
Answer: Preventing pregnancy

Flashcard 2
Question: What is the main mechanism by which progesterone prevents pregnancy?
Answer: Prevention of ovulation

Flashcard 3
Question: How does progesterone prevent ovulation at the follicular level?
Answer: Inhibits follicular development

Flashcard 4
Question: Where does progestogen exert negative feedback to decrease GnRH pulse frequency?
Answer: Hypothalamus

Flashcard 5
Question: Progestogen-negative feedback reduces the pulse frequency of what hormone?
Answer: GnRH (Gonadotropin-Releasing Hormone)

Flashcard 6
Question: Decreased GnRH pulse frequency leads to reduced secretion of what two hormones?
Answer: FSH & LH (Follicle-Stimulating Hormone & Luteinizing Hormone)

Flashcard 7
Question: Reduced FSH secretion due to progesterone prevents the development of what ovarian structure?
Answer: Follicle

Flashcard 8
Question: Why do estradiol levels not increase when follicular development is inhibited?
Answer: Follicle (source of estradiol) doesn't develop

Flashcard 9
Question: The absence of what surge is caused by progestogen-negative feedback and lack of estrogen-positive feedback?
Answer: Mid-cycle LH surge

Flashcard 10
Question: No follicle development and no LH surge are reasons for the prevention of what event?
Answer: Ovulation

Flashcard 11
Question: Besides progesterone, what other hormone also inhibits follicular development (to a lesser extent)?
Answer: Estrogen

Flashcard 12
Question: How does estrogen inhibit follicular development?
Answer: Negative feedback on anterior pituitary, slowing FSH secretion

Flashcard 13
Question: Besides preventing ovulation, how else does progesterone prevent sperm from reaching the egg?
Answer: Makes cervical mucus unfriendly to sperm

Flashcard 14
Question: Progesterone induces what change in the endometrium that deters implantation?
Answer: Endometrial atrophy

Flashcard 15
Question: How does progesterone-induced endometrial atrophy deter pregnancy?
Answer: Deters implantation