id  Date    Col_1   Col_2   Col_3
26  2012-10-18  X   25.7    True
42  2012-10-19  Y   -12.4   False
63  2012-10-20  Z   5.73    True

In [437]: data.to_sql('data', engine)

In [438]: data.to_sql('data_chunked', engine, chunksize=1000)

for row in data.iterrows():

import psycopg2

# Fill in the blanks for the conn object
conn = psycopg2.connect(user = 'user',
                              password = 'password',
                              host = 'host',
                              dbname = 'db',
                              port = 666)
cursor = conn.cursor()

args_str = b','.join(cursor.mogrify("(%s,%s,...)", x) for x in tuple(map(tuple,np_data)))
cursor.execute("insert into table (a,b,...) VALUES "+args_str.decode("utf-8"))

cursor.close()
flexprobi_conn.commit()
flexprobi_conn.close()