import wx

class MyFrame(wx.Frame):
    def __init__(self):
        wx.Frame.__init__(self, None,
                          pos=wx.DefaultPosition, size=wx.Size(450,100),
                          style=wx.MINIMIZE_BOX | wx.SYSTEM_MENU | wx.CAPTION |
                          wx.CLOSE_BOX | wx.CLIP_CHILDREN, title="Python Assistan")
        panel = wx.Panel(self)
        my_sizer = wx.BoxSizer(wx.VERTICAL)
        lbl = wx.StaticText(panel)
        label="Hi I am Jarvis. How can I help you?"
        my_sizer.Add(lbl,0,wx.ALL, 5)

        self.txt = wx.TextCtrl(panel, style=wx.TE_PROCESS_ENTER, size=(400, 30))
        self.txt.SetFocus()
        self.txt.Bind(wx.EVT_TEXT_ENTER, self.OnEnter)

        my_sizer.Add(self.txt, 0, wx.ALL, 5)
        panel.SetSizer(my_sizer)

        self.Show()


    def OnEnter(self, event):
        line = self.txt.GetValue()
        line = line.lower()


if __name__ == "__main__":
    app = wx.App(True)
    fraem = MyFrame()
    app.MainLoop()

$ pip install wxPython
Collecting wxPython
  Using cached wxPython-4.0.1-cp27-cp27m-macosx_10_6_intel.whl
Requirement already satisfied: six in /System/Library/Frameworks/Python.framework/Versions/2.7/Extras/lib/python (from wxPython)
Installing collected packages: wxPython
Exception:
Traceback (most recent call last):
  File "/Library/Python/2.7/site-packages/pip-9.0.2-py2.7.egg/pip/basecommand.py", line 215, in main
    status = self.run(options, args)
  File "/Library/Python/2.7/site-packages/pip-9.0.2-py2.7.egg/pip/commands/install.py", line 342, in run
    prefix=options.prefix_path,
  File "/Library/Python/2.7/site-packages/pip-9.0.2-py2.7.egg/pip/req/req_set.py", line 784, in install
    **kwargs
  File "/Library/Python/2.7/site-packages/pip-9.0.2-py2.7.egg/pip/req/req_install.py", line 851, in install
    self.move_wheel_files(self.source_dir, root=root, prefix=prefix)
  File "/Library/Python/2.7/site-packages/pip-9.0.2-py2.7.egg/pip/req/req_install.py", line 1064, in move_wheel_files
    isolated=self.isolated,
  File "/Library/Python/2.7/site-packages/pip-9.0.2-py2.7.egg/pip/wheel.py", line 345, in move_wheel_files
    clobber(source, lib_dir, True)
  File "/Library/Python/2.7/site-packages/pip-9.0.2-py2.7.egg/pip/wheel.py", line 316, in clobber
    ensure_dir(destdir)
  File "/Library/Python/2.7/site-packages/pip-9.0.2-py2.7.egg/pip/utils/__init__.py", line 83, in ensure_dir
    os.makedirs(path)
  File "/System/Library/Frameworks/Python.framework/Versions/2.7/lib/python2.7/os.py", line 157, in makedirs
    mkdir(name, mode)
OSError: [Errno 13] Permission denied: '/Library/Python/2.7/site-packages/wx'