pip install -r requirements.txt --user -upgrade

Usage:
  pip install [options] <requirement specifier> [package-index-options] ...
  pip install [options] -r <requirements file> [package-index-options] ...
  pip install [options] [-e] <vcs project url> ...
  pip install [options] [-e] <local project path> ...
  pip install [options] <archive url/path> ...

no such option: -u