Did some tinkering with goodies code then I found another code to learn from:
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#!/usr/bin/env python
# -*-coding:utf-8-*-
import time
from time import sleep
import random

sus="-"*35
depo=["rock","paper","scissors","lizard","spock"]
while True:
    x=input("rock, paper, scissors: ")
    if x not in depo:
        print ("Don't cheat!")
        continue

    pc=random.choice(depo)
    sleep(0.5)
    print (("Computer picked {}.").format(pc))
    if x==pc:
        sleep(0.5)
        print (("\nIt's a draw.\n{}").format(sus))
    elif x=="rock" and pc=="scissors":
        sleep(0.5)
        print (("\nYou win.rock beats scissors\n{}").format(sus))
    elif x=="rock" and pc=="paper":
        sleep(0.5)
        print (("\nYou lose.paper beats rock\n{}").format(sus))
    elif x=="paper" and pc=="rock":
        sleep(0.5)
        print (("\nYou win.paper beats rock\n{}").format(sus))
    elif x=="paper" and pc=="scissors":
        sleep(0.5)
        print (("\nYou lose.scissors beats paper\n{}").format(sus))
    elif x=="scissors" and pc=="paper":
        sleep(0.5)
        print (("\nYou win.scissors beats paper\n{}").format(sus))
    elif x=="scissors" and pc=="rock":
        sleep(0.5)
        print (("\nYou lose.rock beats scissors\n{}").format(sus))

    else:
        sleep(0.5)
        print (("\nYou lose. {} beats {}\n{}").format(pc,x,sus))
input()

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--------------------------------------------------------------------------
Made alot of modifications and made this...
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import os, time
from time import sleep
import random
def cls():
    if os.name == 'nt':
        os.system('cls')
    else:
        os.system("clear")


sus="-"*35
depo=["rock","paper","scissors","lizard","spock"]
while True:
    x=input("rock, paper, scissors, lizard, or spock: ")
    cls()
    if x not in depo:
        print ("Make a Decision!")
        continue


    pc=random.choice(depo)
    sleep(0.5)
    print (("Computer picked {}.").format(pc))
    if x==pc:
        sleep(0.5)
        print (("\nIt's a draw.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()


    elif x=="rock" and pc=="scissors":
        sleep(0.5)
        print (("\nYOU WIN! Rock smashes scissors.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()
    elif x=="rock" and pc=="spock":
        sleep(0.5)
        print (("\nYOU LOSE! Spock vaporizes rock.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()
    elif x=="rock" and pc=="lizard":
        sleep(0.5)
        print (("\nYOU WIN! Rock crushes lizard.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()
    elif x=="rock" and pc=="paper":
        sleep(0.5)
        print (("\nYOU LOSE! Paper covers rock.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()


    elif x=="paper" and pc=="rock":
        sleep(0.5)
        print (("\nYOU WIN! Paper beats rock,\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()
    elif x=="paper" and pc=="scissors":
        sleep(0.5)
        print (("\nYOU LOSE! Scissors cut paper\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()
    elif x=="paper" and pc=="spock":
        sleep(0.5)
        print (("\nYOU WIN! Paper dispoves Spock.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()
    elif x=="paper" and pc=="lizard":
        sleep(0.5)
        print (("\nYOU LOSE! Lizard eats paper.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()


    elif x=="scissors" and pc=="paper":
        sleep(0.5)
        print (("\nYOU WIN! Scissors cuts paper.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()
    elif x=="scissors" and pc=="lizard":
        sleep(0.5)
        print (("\nYOU WIN! Scissors decapitates liazrd.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()
    elif x=="scissors" and pc=="spock":
        sleep(0.5)
        print (("\nYOU LOSE!Spock smashes scissors.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()
    elif x=="scissors" and pc=="rock":
        sleep(0.5)
        print (("\nYOU LOSE! Rock smashes scissors.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()


    elif x=="lizard" and pc=="paper":
        sleep(0.5)
        print (("\nYOU WIN! Lizard eats paper.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()
    elif x=="lizard" and pc=="rock":
        sleep(0.5)
        print (("\nYOU LOSE! Rock crushes lizard.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()
    elif x=="lizard" and pc=="spock":
        sleep(0.5)
        print (("\nYOU WIN! Lizard poisons Spock.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()
    elif x=="lizard" and pc=="scissors":
        sleep(0.5)
        print (("\nYOU LOSE! Scissors decapitates lizard.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()


    elif x=="spock" and pc=="paper":
        sleep(0.5)
        print (("\nYOU LOSE! Paper disproves Spock.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()
    elif x=="spock" and pc=="scissors":
        sleep(0.5)
        print (("\nYOU WIN! Spock smashes scissors.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()
    elif x=="spock" and pc=="lizard":
        sleep(0.5)
        print (("\nYOU LOSE! Lizard poisons Spock.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()
    elif x=="spock" and pc=="rock":
        sleep(0.5)
        print (("\nYOU WIN! Spock vaporizes rock.\n{}").format(sus))
        input("Try Again? Press Enter to Continue... ")
        cls()


    else:
        sleep(0.5)
        print (("\nYOU LOSE! {} beats {}\n{}").format(pc,x,sus))
        input("Try Again? Press Enter to Continue... ")
        cls()
input()

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I really want to make a exit option with this and possibly keep score... also when the computer decides it shows some ascii of a hand doing the option it chooses.