Press and hold CTRL + ALT and click on the interface item you want to assign a hotkey to. This could be a button, a slider or a palette.
    Press the key on your keyboard you want to assign the interface item to or press ESC to exit.

When a hotkey is assigned to a palette the top center of the palette will appear under your cursor when you press the hotkey. If the entire palette can not show within in the interface the palette will be moved vertically upwards until it fits into the ZBrush window.

To assign a brush to a key follow the steps below:

    Press and hold CTRL + ALT and click on the brush in the Brush palette. You can click on a brush icon in the Brush palette or in the Brush pop-up.
    Press the key on your keyboard you want to assign the interface item to or press ESC to exit.

You can also change the last letter hotkey used to pick a brush from the brush popup, such as changing the default B+S+T for the Standard Brush to B+S+X :

    Press B so the brush popup shows.
    Press the initial letter of the brush you want (for example, S for Standard Brush)
    Hold Ctrl+Alt and click on the brush icon in the popup.
    Press the key on your keyboard that you want to use.

Focal Shift - Softness of Brush
Lightbox - Presets
IMM Select One Then Press M to Access Brush Set
Transpose Master - T-Pose Mesh (Collapse All Subtools) - Make Changes - Split Again
Move Topology
S - Change Brush Size - Brush Resizing Hotkeys are [ ]
Make Tooth - Insert Cilinder Split Tool - Clip Curve + Clip Circle - Add Holes - Insert Spheres (No Subdivision Levels) - Split Similar Parts - Snake Brush
Shift+F PolyFrame - Resolution
Micro Detail Alphas (Asimetrical, Pose, Wrinkles) After Secondary Forms on Different Layers (Blend)
Standard Brush Gravity on wrinkles
Form Soft Brush - Smooth Maintain Details
Final Pose - Put Subtools on Different Layers
Preferences Enable Customize - Stop Conflict - Save Layout
X-Ray Mode
Curve Tube Brush - Access Curve Modifier Graph for Different Strokes
Ctrl+Click Outside Mask - Inverts Mask / Ctrl+Click on Mask - Blur / Ctrl+Alt on Mask - Sharp
Curve Tube Brush
M - Subtools Shortcut
ZAppLink - The Image Plane plugin provides a set of eight Reference Views that can be set up so that model positions match background images
Tooth - Move Brush + Dam Brush + Clay Tubes
Mask by Color - Inflate Details
Move Brush - Inflate - Dam Standard - Clay Buildup - Clay Tubes - Snake Brush - Trim Dynamic
Use Texture to Model Details
Render - Shift+R / Export Shader Pass by Clicking on It / Render Light on Different Positions / Reflected Mat for Specular
Avoid Losing Detail on ZRemesh - Project All
spotlight Texture - RGB (on) | shift+C (Hide/Show) / C - (Show/Hide Wheel)
ZBrush Plugin Pose
Color Spray Brush (Low Intensity) Start with Dark Colors then Bright Ones / First Warm Colors Then Cool Tones
Photoshop Layers Order - Mask - Specular - Ambient Occlusion - Depth - Shadow Pass (Multiply) - Back, Top, Bottom, Left, Right Lights - Main Front Light
Photoshop Back-Top/One-Side Light on Screen Mode + Crank Levels for Highlights
Photoshop SSS - Levels + Colorize + Screen Mode / Tint Ambient Oclussion
>ZPlugin >SubTool Master >Mirror
Choose Color - C
Shift - Hide/Show Tools
Ctrl+D - Subdivide | Shift+D Low Res
ZRemesher - Low Poly Mesh
Alt+Click - Select Subtool
Press A to Preview Geometry From ZSpheres
Auto-Backface Masking Turn On on All Brushes
Smooth Directional Brush
Alt+Click Selects Subtool
Insert Brush to Insert Geometry
ZPlugin Transpose Master - Advance Pose
>Mask >Extraction >Inflate >Trim Dynamics
>Mask >Geometry Tab >Delete Hidden - Make a Polygroup
Trim Dynamic Brush - Quick Planes on Blocking
Slice Brush - Cuts + Alt - Bevel
Remove Hidden - Removes Offscreen Geometry
Clip Curve Brush - Flats Surface
Planar Brush + Alt - Flats Surface
Alt + ZRemesher - Different Algorithm
Geometry "Dyn" Loops '100/-100' Elevation - Thickness
Group by Normals
Polysh by Group
Dynamic Subdivision - Preview Subdivisions
Geometry Crease - Smooth Afterwards
Curve Tube Brush >When Polygroups Meet >shift >Makes Indent
Trim Hole Brush - Cilinder Hole
Mask >Ctrl Click on Surface >Extract Mask - Create Creases / Ctrl+Click Inverted Mask - Different Result
Make a Shortcut for Repeat Last

Create Layers for Fix Rigged Motions >Bake
Method 1 - Create UVs outside of ZBrush: Set Tool: Geometry: SDiv to 1. Export mesh by pressing Tool: Export. Layout UVs in your other application
Method 2 - Create UVs inside of ZBrush: Set Tool: Geometry: SDiv to 1. Press Tool > UV Map > PUV or use UV Master

Setting Up Reference Views - If a model is in Edit/Transform mode then the image will be placed behind the model for use as a reference image. To set up reference images for your project:

    Place a model in Edit mode – any model will do, as it can be swapped at any time.
    Press the Front button in the Image Plane>Reference Views menu.
    Press the Load Image button and select the image you wish to use for the front reference.
    Scale and position your model if you wish.
    Press the Store View button to store the image and model position.
    Repeat for those other views you wish to use.

Reference Views controls

Pressing the Front, Back, Right etc. buttons will switch to that view. If the view is already selected then pressing the button will reposition the model and reset the background image.

The Model Opacity slider will adjust the opacity of the model against the reference image. Some materials are better than others to work with – for example, the FlatSketch01 is good for showing some of the wireframe as you work.

The Store View button will store model scale, position and background image (if there is one) for the selected view. Shift+clicking the button will adjust all views to reflect changes in scale.

The << and >> buttons will cycle forwards or backwards through the different views.

Saving a Reference Views project

To save a Reference Views project simply save the ZBrush project (ZPR file) by pressing the File>Save As button. Load the project back in using the File>Open button.Reference Views controls

Pressing the Front, Back, Right etc. buttons will switch to that view. If the view is already selected then pressing the button will reposition the model and reset the background image.

The Model Opacity slider will adjust the opacity of the model against the reference image. Some materials are better than others to work with – for example, the FlatSketch01 is good for showing some of the wireframe as you work.

The Store View button will store model scale, position and background image (if there is one) for the selected view. Shift+clicking the button will adjust all views to reflect changes in scale.