import wmi

nic_configs = wmi.WMI('').Win32_NetworkAdapterConfiguration(IPEnabled=True)

# First network adaptor
nic = nic_configs[0]

# IP address, subnetmask and gateway values should be unicode objects
ip = u'192.168.0.151'
subnetmask = u'255.255.255.0'
gateway = u'192.168.0.1'
dns = u'192.168.0.1'

# Set IP address, subnetmask and default gateway
a = nic.EnableStatic(IPAddress=[ip],SubnetMask=[subnetmask])
b = nic.SetGateways(DefaultIPGateway=[gateway])

# Set DNS Server list
c = nic.SetDNSServerSearchOrder(dns)
d = nic.SetDynamicDNSRegistration(true)

# These are just for some debugging so that I can see the return codes of the methods
print(a)
print(b)
print(c)
print(d)