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(Simplified version an old problem, here with 8 bottles instead of 1000)
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(Simplified version an old problem, here with 16 bottles instead of 1000)
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A king has 8 bottles of wine of which one (unknown) has deadly poison in it. If one drinks even a drop of the poisoned wine one will die within three weeks. 
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A king has 16 bottles of wine of which one (unknown) has deadly poison in it. If one drinks even a drop of the poisoned wine one will die within three weeks. 
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The king will have a party in four weeks and wants to figure out before that which bottle is poisoned so that he can discard it.
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He has only a few servants who he is willing to sacrifice in order to test this. 
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He has some servants who he is willing to sacrifice in order to test this. 
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The typical solution here is to use the binary system so that you need to sacrifice 3 servants in order to test 8 bottles. 
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The typical solution here is to use the binary system so that you need to sacrifice 4 servants in order to test 16 bottles. 
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There is a problem though, namely the fact that people sometimes die for other reasons. For example if all 3 die, then that could be because bottle 7 was poisoned, but it could also be bottle 5 and that servant 2 died for some other reason. This would lead to discarding bottle 7 when it is actually bottle 5 that is poisonous.
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There is a problem though, namely the fact that people sometimes die for other reasons. For example if the the 3 first servants die, then that could be because bottle 7 was poisoned, but it could also be bottle 5 and that servant 2 died for some other reason. This would lead to discarding bottle 7 when it is actually bottle 5 that is poisonous, so a fatal mistake.
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My question is, how can one improve the certainty? How many servants are needed with your improved method?