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Starting items tierlist:
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General: (As a general rule, i do not check curse rooms while resetting so items like brim are not starts)
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God tier: Knife, Ipecac
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Tier A: Epic fetus, Dr Fetus, Tech X, 20/20.
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Tier B: Crickets Head, Magic mush, Judas shadow, Lil Brimstone, Proptosis
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Tier B-: Monstros lung, sac dagger, deaths touch, Crickets body
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Tier C: Poly, Quad shot
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Tier C-: Cursed Eye
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Tier D (Not real starts, only check-curse-room or desesperation start items) Choco milk, The mind, Guillotine, Crystal Ball
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Character-specific:
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Eden: Not running anything that is not a tier A+ item or a B- item with something else (Like Mush+Pact in curse room). Synergies between items not listed there like tammy brim or isaacs heart blood rights are a start obviously. Checking b1/b2 treasure room with Isaacs heart or Blood rights (Looking for the other combo piece)
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Blue Baby: No specific changes
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Samson: Scapular is a tier B start here. Also crickets body is not a start, and prop is tier B-.
16+
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Eve: Curse rooms are worth checking if i need to catch up.
17+
Samson: Scapular is a tier B start here. Also crickets body is not a start
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Eve: ¿Curse rooms are worth checking? Still need to test that more times. 
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Judas: Not checking curse room with tier D items
19+
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Judas: Not checking curse room with tier D items.
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Isaac: No specific changes
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Lazarus: Check for telepill into i am error room with tier D items, check for tears up pill with mind.
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Azazel: Unbalanced char boys, no specific changes.
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The Lost: Sac dagger is not a start here.
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Keeper: Quad shot, poly, crickets body and tier D items are not starts here.