location ~* ^/zzz/(.)/(.*) {
                    rewrite "/zzz/(.)/([0-9,a-z] {2})([0-9,a-z] {2})" /$1/$2/$1$2(.*);
                    root /home/project;
            }

запрашиваю: sub.domain.com/zzz/0/4e0a3a54d3a5s4d3as54d3a54/file.dat
лог пишет: "/home/project/zzz/0/4e0a3a54d3a5s4d3as54d3a54/file.dat" No such file or directory "GET /zzz/0/4e0a3a54d3a5s4d3as54d3a54/file.dat , host: "sub.domain.com"