CreateMap<SourceType, DestinationType>()
   // here goes some actual mapping code:
   .ForMember(dest => dest.DestMember, opt => opt.MapFrom(src => src.SourceMember))
   // and then go the explicitly ignored unmapped dest members,
   // just for AssertConfigurationIsValid to pass:
   .ForMember(dest => dest.IgnoredMember, opt => opt.Ignore());

[TestMethod]
public void TestMappingConfiguration()
{
  Mapper.AddProfile<MyProfile>();
  Mapper.FindTypeMapFor<SourceType, DestinationType>()
    .ForMember(dest => dest.IgnoredMember, opt => opt.Ignore());
  Mapper.AssertConfigurationIsValid(MyProfile.Name);
}