Ok here it is :
jemoh@Hiuhu:~$ vim window.py
#!/usr/bin/env/ python

import pygtk
pygtk.require('2.0')
import gtk

class Base:
    def destrpy(self,widget,data=none):
        gtk.main_quit()

    def __init__(self):
        self.window = gtk.Window(gtk.WINDOW_TOPLEVEL)
        self.window.show()
        self.window.connect("destroy", self.destroy)

    def main(self):
        gtk.main()

if __name__ == "__main__"
     base = Base()
     base.main()
"window.py" 21L, 409C                                         1,1           All
jemoh@Hiuhu:~$ chmod +x window.py
jemoh@Hiuhu:~$ ./window.py
bash: ./window.py: /usr/bin/env/: bad interpreter: Not a directory