add_action( 'pre_get_posts', 'be_exclude_category_from_blog' );
/**
 * Exclude Category from Blog
 *
 * @author Bill Erickson
 * @link http://www.billerickson.net/customize-the-wordpress-query/
 * @param object $query data
 *
 */
function be_exclude_category_from_blog( $query ) {

    if( $query->is_main_query() && $query->is_home() ) {
        $query->set(  'cat', '-2258, -2806, -2695, -2654, -2767'  );
            $query->set( 'posts_per_page', '53' );
    }

}