import datetime
import numpy as np
import pandas as pd

def business_date_diff(start, end):
    mask = pd.notnull(start) & pd.notnull(end)
    start = start[mask]
    end = end[mask]
    start = start.values.astype('datetime64[D]')
    end = end.values.astype('datetime64[D]')
    result = np.empty(len(mask), dtype=float)
    result[mask] = np.busday_count(start, end)
    result[~mask] = np.nan
    return result

print start[0:5]
print end[0:5]
print np.busday_count(start, end)[0:5]

# ['2016-07-04' '2016-07-04' '2016-07-04' '2016-07-04' '2016-07-04']
# ['2016-07-05' '2016-07-05' '2016-07-05' '2016-07-06' '2016-07-06']
# [1 1 1 2 2]

...
result = np.empty(len(mask), dtype=float)
result[mask] = np.busday_count(start, end)
result[~mask] = np.nan
print result

# [           nan               nan   1.43700866e-210   1.45159738e-210
# 1.45159738e-210   1.45159738e-210   1.45159738e-210   1.46618609e-210
# 1.45159738e-210   1.64491834e-210   1.45159738e-210   1.43700866e-210
# 1.43700866e-210   1.43700866e-210   1.43700866e-210   1.45159738e-210
# 1.43700866e-210   1.43700866e-210   1.43700866e-210   1.43700866e-210