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  2. <!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
  3. <pre>
  4. &lt;PubmedArticle&gt;
  5. &lt;MedlineCitation Status="Publisher" Owner="NLM"&gt;
  6. &lt;PMID Version="1"&gt;23314841&lt;/PMID&gt;
  7. &lt;DateCreated&gt;
  8. &lt;Year&gt;2013&lt;/Year&gt;
  9. &lt;Month&gt;1&lt;/Month&gt;
  10. &lt;Day&gt;14&lt;/Day&gt;
  11. &lt;/DateCreated&gt;
  12. &lt;Article PubModel="Print-Electronic"&gt;
  13. &lt;Journal&gt;
  14. &lt;ISSN IssnType="Electronic"&gt;1432-0932&lt;/ISSN&gt;
  15. &lt;JournalIssue CitedMedium="Internet"&gt;
  16. &lt;PubDate&gt;
  17. &lt;Year&gt;2013&lt;/Year&gt;
  18. &lt;Month&gt;Jan&lt;/Month&gt;
  19. &lt;Day&gt;12&lt;/Day&gt;
  20. &lt;/PubDate&gt;
  21. &lt;/JournalIssue&gt;
  22. &lt;Title&gt;European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society&lt;/Title&gt;
  23. &lt;ISOAbbreviation&gt;Eur Spine J&lt;/ISOAbbreviation&gt;
  24. &lt;/Journal&gt;
  25. &lt;ArticleTitle&gt;Indocyanine green videoangiography &amp;quot;in negative&amp;quot;: definition and usefulness in spinal dural arteriovenous fistulae.&lt;/ArticleTitle&gt;
  26. &lt;Pagination&gt;
  27. &lt;MedlinePgn/&gt;
  28. &lt;/Pagination&gt;
  29. &lt;Abstract&gt;
  30. &lt;AbstractText&gt;PURPOSE: Indocyanine green videoangiography (IGV) has proven its effectiveness in the field of exovascular neurosurgery, both in the intracranial and spinal compartment, but is necessary to define a systematic process for the performance of the IGV to facilitate its interpretation during the procedure. We have defined and applied the concept of videoangiography &amp;quot;in negative&amp;quot; (INIGV) to spinal dural arteriovenous fistulae (dAVF) for the detection and treatment of arteriovenous shunts, so called because the first phase is performed with the vessel suggestive of being pathological occluded. METHODS: A Pentero-operating microscope with near-infrared IGV-integrated system (Carl Zeiss Co., Germany) was used. At our institution, 24 patients were treated for a spinal dAVF between 1995 and 2011, only in the last 4 cases, INIGV was performed. RESULTS: We describe the IGV in negative procedure and show the most illustrative cases. In all cases, the fistula occlusion was confirmed by postoperative selective digital subtraction angiography (DSA). INIGV demonstrate its capacity in detecting vessels not actually arterialized that should be respected and avoid some of the main limitations of the conventional IGV. This is a technical description about an Indocyanine green (ICG) videoangiographic procedure modification that is superior to merely performing ICG before and after clipping of a dAVF. CONCLUSION: The INIGV results are rapid and easy to interpret procedure and provide great advantages to the dAVF treatment. Nevertheless, further studies are needed with a larger sample size to determine if INIGV may reduce the need to perform immediate postoperative DSA.&lt;/AbstractText&gt;
  31. &lt;/Abstract&gt;
  32. &lt;Affiliation&gt;Neurosurgical Department, HUyP La Fe de Valencia, Blv Sur, S/N., Valencia, Spain, juanantonio.simal@gmail.com.&lt;/Affiliation&gt;
  33. &lt;AuthorList&gt;
  34. &lt;Author&gt;
  35. &lt;LastName&gt;Simal Julián&lt;/LastName&gt;
  36. &lt;ForeName&gt;Juan Antonio&lt;/ForeName&gt;
  37. &lt;Initials&gt;JA&lt;/Initials&gt;
  38. &lt;/Author&gt;
  39. &lt;Author&gt;
  40. &lt;LastName&gt;Miranda Lloret&lt;/LastName&gt;
  41. &lt;ForeName&gt;Pablo&lt;/ForeName&gt;
  42. &lt;Initials&gt;P&lt;/Initials&gt;
  43. &lt;/Author&gt;
  44. &lt;Author&gt;
  45. &lt;LastName&gt;López González&lt;/LastName&gt;
  46. &lt;ForeName&gt;Antonio&lt;/ForeName&gt;
  47. &lt;Initials&gt;A&lt;/Initials&gt;
  48. &lt;/Author&gt;
  49. &lt;Author&gt;
  50. &lt;LastName&gt;Evangelista Zamora&lt;/LastName&gt;
  51. &lt;ForeName&gt;Rocío&lt;/ForeName&gt;
  52. &lt;Initials&gt;R&lt;/Initials&gt;
  53. &lt;/Author&gt;
  54. &lt;Author&gt;
  55. &lt;LastName&gt;Botella Asunción&lt;/LastName&gt;
  56. &lt;ForeName&gt;Carlos&lt;/ForeName&gt;
  57. &lt;Initials&gt;C&lt;/Initials&gt;
  58. &lt;/Author&gt;
  59. &lt;/AuthorList&gt;
  60. &lt;Language&gt;ENG&lt;/Language&gt;
  61. &lt;PublicationTypeList&gt;
  62. &lt;PublicationType&gt;JOURNAL ARTICLE&lt;/PublicationType&gt;
  63. &lt;/PublicationTypeList&gt;
  64. &lt;ArticleDate DateType="Electronic"&gt;
  65. &lt;Year&gt;2013&lt;/Year&gt;
  66. &lt;Month&gt;1&lt;/Month&gt;
  67. &lt;Day&gt;12&lt;/Day&gt;
  68. &lt;/ArticleDate&gt;
  69. &lt;/Article&gt;
  70. &lt;MedlineJournalInfo&gt;
  71. &lt;MedlineTA&gt;Eur Spine J&lt;/MedlineTA&gt;
  72. &lt;NlmUniqueID&gt;9301980&lt;/NlmUniqueID&gt;
  73. &lt;ISSNLinking&gt;0940-6719&lt;/ISSNLinking&gt;
  74. &lt;/MedlineJournalInfo&gt;
  75. &lt;/MedlineCitation&gt;
  76. &lt;PubmedData&gt;
  77. &lt;History&gt;
  78. &lt;PubMedPubDate PubStatus="received"&gt;
  79. &lt;Year&gt;2012&lt;/Year&gt;
  80. &lt;Month&gt;3&lt;/Month&gt;
  81. &lt;Day&gt;13&lt;/Day&gt;
  82. &lt;/PubMedPubDate&gt;
  83. &lt;PubMedPubDate PubStatus="accepted"&gt;
  84. &lt;Year&gt;2012&lt;/Year&gt;
  85. &lt;Month&gt;12&lt;/Month&gt;
  86. &lt;Day&gt;22&lt;/Day&gt;
  87. &lt;/PubMedPubDate&gt;
  88. &lt;PubMedPubDate PubStatus="aheadofprint"&gt;
  89. &lt;Year&gt;2013&lt;/Year&gt;
  90. &lt;Month&gt;1&lt;/Month&gt;
  91. &lt;Day&gt;12&lt;/Day&gt;
  92. &lt;/PubMedPubDate&gt;
  93. &lt;PubMedPubDate PubStatus="entrez"&gt;
  94. &lt;Year&gt;2013&lt;/Year&gt;
  95. &lt;Month&gt;1&lt;/Month&gt;
  96. &lt;Day&gt;15&lt;/Day&gt;
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  101. &lt;Year&gt;2013&lt;/Year&gt;
  102. &lt;Month&gt;1&lt;/Month&gt;
  103. &lt;Day&gt;15&lt;/Day&gt;
  104. &lt;Hour&gt;6&lt;/Hour&gt;
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  108. &lt;Year&gt;2013&lt;/Year&gt;
  109. &lt;Month&gt;1&lt;/Month&gt;
  110. &lt;Day&gt;15&lt;/Day&gt;
  111. &lt;Hour&gt;6&lt;/Hour&gt;
  112. &lt;Minute&gt;0&lt;/Minute&gt;
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  114. &lt;/History&gt;
  115. &lt;PublicationStatus&gt;aheadofprint&lt;/PublicationStatus&gt;
  116. &lt;ArticleIdList&gt;
  117. &lt;ArticleId IdType="doi"&gt;10.1007/s00586-012-2646-8&lt;/ArticleId&gt;
  118. &lt;ArticleId IdType="pubmed"&gt;23314841&lt;/ArticleId&gt;
  119. &lt;/ArticleIdList&gt;
  120. &lt;/PubmedData&gt;
  121. &lt;/PubmedArticle&gt;
  122.  
  123.  
  124. &lt;PubmedArticle&gt;
  125. &lt;MedlineCitation Status="Publisher" Owner="NLM"&gt;
  126. &lt;PMID Version="1"&gt;23314479&lt;/PMID&gt;
  127. &lt;DateCreated&gt;
  128. &lt;Year&gt;2013&lt;/Year&gt;
  129. &lt;Month&gt;1&lt;/Month&gt;
  130. &lt;Day&gt;14&lt;/Day&gt;
  131. &lt;/DateCreated&gt;
  132. &lt;Article PubModel="Print-Electronic"&gt;
  133. &lt;Journal&gt;
  134. &lt;ISSN IssnType="Electronic"&gt;1435-702X&lt;/ISSN&gt;
  135. &lt;JournalIssue CitedMedium="Internet"&gt;
  136. &lt;PubDate&gt;
  137. &lt;Year&gt;2013&lt;/Year&gt;
  138. &lt;Month&gt;Jan&lt;/Month&gt;
  139. &lt;Day&gt;12&lt;/Day&gt;
  140. &lt;/PubDate&gt;
  141. &lt;/JournalIssue&gt;
  142. &lt;Title&gt;Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie&lt;/Title&gt;
  143. &lt;ISOAbbreviation&gt;Graefes Arch. Clin. Exp. Ophthalmol.&lt;/ISOAbbreviation&gt;
  144. &lt;/Journal&gt;
  145. &lt;ArticleTitle&gt;Agreement of IOL power and axial length obtained by IOLMaster 500 vs IOLMaster 500 with Sonolink connection.&lt;/ArticleTitle&gt;
  146. &lt;Pagination&gt;
  147. &lt;MedlinePgn/&gt;
  148. &lt;/Pagination&gt;
  149. &lt;Abstract&gt;
  150. &lt;AbstractText&gt;BACKGROUND: The accurrate and expedient ocular biometry is essential for modern cataract surgery. IOLMaster 500, one of the most popular partial coherence interferometry (PCI) device, has been widely used. However, with the PCI device, it is difficult to obtain the axial length through densely opaque media. With the current version of IOLMaster 500, a unique feature is added to link with the Synergy immersion A-scan ultrasound (sonolink connection). In case of failure to measure axial length by IOLMaster 500, the axial length can be obtained by ultrasound, and then transferred to IOLMaster 500 for the IOL power calculation. This study aims to compare the results and evaluate the agreement between IOL power and axial length obtained by IOLMaster 500 and IOLMaster 500 with sonolink connection. METHODS: A prospective study of 60 eyes in 60 mild-to-moderate cataract patients was conducted under Institutional Ethics Committee approval. Keratometry (K) and axial length (AL) of all eyes were measured using IOLMaster 500 (Carl Zeiss, Germany), then IOL power was generated using Holladay 1 formula (group 1). After 5 min, the K measurements were repeated with IOLMaster 500 and the AL were measured again using the Synergy A-scan ultrasound (Accutome, USA). Then, the AL data were transferred to IOLMaster 500 via the sonolink connection to generate the IOL power using the same setting (group 2). The IOL power and AL were compared between the two groups, and the agreement was evaluated using intraclass correlation coefficient (ICC) and the Bland-Altman method. RESULTS: The mean IOL power in group 1 was 21.04 + 2.36 D and group 2 was 21.03 + 2.36 D. The mean AL in group 1 was 23.35 + 0.86 mm and in group 2 was 23.36 + 0.86 mm. There was no statistically significant difference in IOL power and AL between the two groups. The agreements in IOL power and AL between both groups were high (ICCs = 0.997 for IOL power and 0.993 for AL) CONCLUSIONS: The IOL power and AL derived from both groups were similar. The agreements between them were high.&lt;/AbstractText&gt;
  151. &lt;/Abstract&gt;
  152. &lt;Affiliation&gt;Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.&lt;/Affiliation&gt;
  153. &lt;AuthorList&gt;
  154. &lt;Author&gt;
  155. &lt;LastName&gt;Srivannaboon&lt;/LastName&gt;
  156. &lt;ForeName&gt;Sabong&lt;/ForeName&gt;
  157. &lt;Initials&gt;S&lt;/Initials&gt;
  158. &lt;/Author&gt;
  159. &lt;Author&gt;
  160. &lt;LastName&gt;Chirapapaisan&lt;/LastName&gt;
  161. &lt;ForeName&gt;Chareenun&lt;/ForeName&gt;
  162. &lt;Initials&gt;C&lt;/Initials&gt;
  163. &lt;/Author&gt;
  164. &lt;Author&gt;
  165. &lt;LastName&gt;Nantasri&lt;/LastName&gt;
  166. &lt;ForeName&gt;Patchara&lt;/ForeName&gt;
  167. &lt;Initials&gt;P&lt;/Initials&gt;
  168. &lt;/Author&gt;
  169. &lt;Author&gt;
  170. &lt;LastName&gt;Chongchareon&lt;/LastName&gt;
  171. &lt;ForeName&gt;Mathinee&lt;/ForeName&gt;
  172. &lt;Initials&gt;M&lt;/Initials&gt;
  173. &lt;/Author&gt;
  174. &lt;Author&gt;
  175. &lt;LastName&gt;Chonpimai&lt;/LastName&gt;
  176. &lt;ForeName&gt;Pratuangsri&lt;/ForeName&gt;
  177. &lt;Initials&gt;P&lt;/Initials&gt;
  178. &lt;/Author&gt;
  179. &lt;/AuthorList&gt;
  180. &lt;Language&gt;ENG&lt;/Language&gt;
  181. &lt;PublicationTypeList&gt;
  182. &lt;PublicationType&gt;JOURNAL ARTICLE&lt;/PublicationType&gt;
  183. &lt;/PublicationTypeList&gt;
  184. &lt;ArticleDate DateType="Electronic"&gt;
  185. &lt;Year&gt;2013&lt;/Year&gt;
  186. &lt;Month&gt;1&lt;/Month&gt;
  187. &lt;Day&gt;12&lt;/Day&gt;
  188. &lt;/ArticleDate&gt;
  189. &lt;/Article&gt;
  190. &lt;MedlineJournalInfo&gt;
  191. &lt;MedlineTA&gt;Graefes Arch Clin Exp Ophthalmol&lt;/MedlineTA&gt;
  192. &lt;NlmUniqueID&gt;8205248&lt;/NlmUniqueID&gt;
  193. &lt;ISSNLinking&gt;0721-832X&lt;/ISSNLinking&gt;
  194. &lt;/MedlineJournalInfo&gt;
  195. &lt;/MedlineCitation&gt;
  196. &lt;PubmedData&gt;
  197. &lt;History&gt;
  198. &lt;PubMedPubDate PubStatus="received"&gt;
  199. &lt;Year&gt;2012&lt;/Year&gt;
  200. &lt;Month&gt;6&lt;/Month&gt;
  201. &lt;Day&gt;6&lt;/Day&gt;
  202. &lt;/PubMedPubDate&gt;
  203. &lt;PubMedPubDate PubStatus="accepted"&gt;
  204. &lt;Year&gt;2012&lt;/Year&gt;
  205. &lt;Month&gt;11&lt;/Month&gt;
  206. &lt;Day&gt;20&lt;/Day&gt;
  207. &lt;/PubMedPubDate&gt;
  208. &lt;PubMedPubDate PubStatus="revised"&gt;
  209. &lt;Year&gt;2012&lt;/Year&gt;
  210. &lt;Month&gt;10&lt;/Month&gt;
  211. &lt;Day&gt;19&lt;/Day&gt;
  212. &lt;/PubMedPubDate&gt;
  213. &lt;PubMedPubDate PubStatus="aheadofprint"&gt;
  214. &lt;Year&gt;2013&lt;/Year&gt;
  215. &lt;Month&gt;1&lt;/Month&gt;
  216. &lt;Day&gt;12&lt;/Day&gt;
  217. &lt;/PubMedPubDate&gt;
  218. &lt;PubMedPubDate PubStatus="entrez"&gt;
  219. &lt;Year&gt;2013&lt;/Year&gt;
  220. &lt;Month&gt;1&lt;/Month&gt;
  221. &lt;Day&gt;15&lt;/Day&gt;
  222. &lt;Hour&gt;6&lt;/Hour&gt;
  223. &lt;Minute&gt;0&lt;/Minute&gt;
  224. &lt;/PubMedPubDate&gt;
  225. &lt;PubMedPubDate PubStatus="pubmed"&gt;
  226. &lt;Year&gt;2013&lt;/Year&gt;
  227. &lt;Month&gt;1&lt;/Month&gt;
  228. &lt;Day&gt;15&lt;/Day&gt;
  229. &lt;Hour&gt;6&lt;/Hour&gt;
  230. &lt;Minute&gt;0&lt;/Minute&gt;
  231. &lt;/PubMedPubDate&gt;
  232. &lt;PubMedPubDate PubStatus="medline"&gt;
  233. &lt;Year&gt;2013&lt;/Year&gt;
  234. &lt;Month&gt;1&lt;/Month&gt;
  235. &lt;Day&gt;15&lt;/Day&gt;
  236. &lt;Hour&gt;6&lt;/Hour&gt;
  237. &lt;Minute&gt;0&lt;/Minute&gt;
  238. &lt;/PubMedPubDate&gt;
  239. &lt;/History&gt;
  240. &lt;PublicationStatus&gt;aheadofprint&lt;/PublicationStatus&gt;
  241. &lt;ArticleIdList&gt;
  242. &lt;ArticleId IdType="doi"&gt;10.1007/s00417-012-2222-2&lt;/ArticleId&gt;
  243. &lt;ArticleId IdType="pubmed"&gt;23314479&lt;/ArticleId&gt;
  244. &lt;/ArticleIdList&gt;
  245. &lt;/PubmedData&gt;
  246. &lt;/PubmedArticle&gt;
  247.  
  248.  
  249. &lt;PubmedArticle&gt;
  250. &lt;MedlineCitation Status="Publisher" Owner="NLM"&gt;
  251. &lt;PMID Version="1"&gt;23313605&lt;/PMID&gt;
  252. &lt;DateCreated&gt;
  253. &lt;Year&gt;2013&lt;/Year&gt;
  254. &lt;Month&gt;1&lt;/Month&gt;
  255. &lt;Day&gt;14&lt;/Day&gt;
  256. &lt;/DateCreated&gt;
  257. &lt;Article PubModel="Print-Electronic"&gt;
  258. &lt;Journal&gt;
  259. &lt;ISSN IssnType="Electronic"&gt;1872-7697&lt;/ISSN&gt;
  260. &lt;JournalIssue CitedMedium="Internet"&gt;
  261. &lt;PubDate&gt;
  262. &lt;Year&gt;2013&lt;/Year&gt;
  263. &lt;Month&gt;Jan&lt;/Month&gt;
  264. &lt;Day&gt;9&lt;/Day&gt;
  265. &lt;/PubDate&gt;
  266. &lt;/JournalIssue&gt;
  267. &lt;Title&gt;International journal of psychophysiology : official journal of the International Organization of Psychophysiology&lt;/Title&gt;
  268. &lt;ISOAbbreviation&gt;Int J Psychophysiol&lt;/ISOAbbreviation&gt;
  269. &lt;/Journal&gt;
  270. &lt;ArticleTitle&gt;Blunted salivary and plasma cortisol response in patients with panic disorder under psychosocial stress.&lt;/ArticleTitle&gt;
  271. &lt;Pagination&gt;
  272. &lt;MedlinePgn/&gt;
  273. &lt;/Pagination&gt;
  274. &lt;ELocationID EIdType="pii"&gt;S0167-8760(13)00017-2&lt;/ELocationID&gt;
  275. &lt;ELocationID EIdType="doi"&gt;10.1016/j.ijpsycho.2013.01.002&lt;/ELocationID&gt;
  276. &lt;Abstract&gt;
  277. &lt;AbstractText&gt;BACKGROUND: Panic disorder (PD) has been associated with an altered activity of the hypothalamic-pituitary-adrenal-cortical (HPA) axis. Recent findings from a patient sample with PD with secondary depression on psychotropic medication using salivary cortisol as outcome measure suggest a non-responsiveness of the HPA-axis under acute psychosocial stress. Salivary cortisol does not necessarily reflect the total plasma cortisol due to interfering variables. Whether the present findings can be replicated on a patient sample with pure PD using both salivary cortisol and total plasma cortisol as outcome variables remains to be elucidated. METHODS: For this study, the Trier Social Stress Test (TSST) was implemented to assess the HPA-axis reactivity indicated by the plasma adreno-corticotropin-hormone (ACTH), plasma cortisol, and salivary cortisol release. The sample included 32 patients diagnosed with PD in a Structured Clinical Interview (SCID). Twelve male and fifteen female patients [mean age=32.87years, SD=11.23] were matched with 32 healthy controls by age and gender. RESULTS: The plasma ACTH, total plasma cortisol and salivary cortisol release increased significantly in both groups due to the psychosocial stress test. The patients with PD showed a decreased plasma and salivary cortisol response as compared to the healthy controls. Plasma cortisol and salivary cortisol were highly correlated in both groups. Conclusion These findings provide strong evidence for a hypo-responsiveness of the HPA-axis as measured in both blood and saliva. Salivary and total plasma cortisol showed a strong concordance of results. Thus, future investigations could consider salivary cortisol as reliable marker of the HPA-axis under psychosocial stress.&lt;/AbstractText&gt;
  278. &lt;CopyrightInformation&gt;Copyright © 2012. Published by Elsevier B.V.&lt;/CopyrightInformation&gt;
  279. &lt;/Abstract&gt;
  280. &lt;Affiliation&gt;Dept. of Psychotherapy and Psychosomatic Medicine, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Germany. Electronic address: katja.petrowski@mailbox.tu-dresden.de.&lt;/Affiliation&gt;
  281. &lt;AuthorList&gt;
  282. &lt;Author&gt;
  283. &lt;LastName&gt;Petrowski&lt;/LastName&gt;
  284. &lt;ForeName&gt;Katja&lt;/ForeName&gt;
  285. &lt;Initials&gt;K&lt;/Initials&gt;
  286. &lt;/Author&gt;
  287. &lt;Author&gt;
  288. &lt;LastName&gt;Wintermann&lt;/LastName&gt;
  289. &lt;ForeName&gt;Gloria-Beatrice&lt;/ForeName&gt;
  290. &lt;Initials&gt;GB&lt;/Initials&gt;
  291. &lt;/Author&gt;
  292. &lt;Author&gt;
  293. &lt;LastName&gt;Schaarschmidt&lt;/LastName&gt;
  294. &lt;ForeName&gt;Marco&lt;/ForeName&gt;
  295. &lt;Initials&gt;M&lt;/Initials&gt;
  296. &lt;/Author&gt;
  297. &lt;Author&gt;
  298. &lt;LastName&gt;Bornstein&lt;/LastName&gt;
  299. &lt;ForeName&gt;Stefan R&lt;/ForeName&gt;
  300. &lt;Initials&gt;SR&lt;/Initials&gt;
  301. &lt;/Author&gt;
  302. &lt;Author&gt;
  303. &lt;LastName&gt;Kirschbaum&lt;/LastName&gt;
  304. &lt;ForeName&gt;Clemens&lt;/ForeName&gt;
  305. &lt;Initials&gt;C&lt;/Initials&gt;
  306. &lt;/Author&gt;
  307. &lt;/AuthorList&gt;
  308. &lt;Language&gt;ENG&lt;/Language&gt;
  309. &lt;PublicationTypeList&gt;
  310. &lt;PublicationType&gt;JOURNAL ARTICLE&lt;/PublicationType&gt;
  311. &lt;/PublicationTypeList&gt;
  312. &lt;ArticleDate DateType="Electronic"&gt;
  313. &lt;Year&gt;2013&lt;/Year&gt;
  314. &lt;Month&gt;1&lt;/Month&gt;
  315. &lt;Day&gt;9&lt;/Day&gt;
  316. &lt;/ArticleDate&gt;
  317. &lt;/Article&gt;
  318. &lt;MedlineJournalInfo&gt;
  319. &lt;MedlineTA&gt;Int J Psychophysiol&lt;/MedlineTA&gt;
  320. &lt;NlmUniqueID&gt;8406214&lt;/NlmUniqueID&gt;
  321. &lt;ISSNLinking&gt;0167-8760&lt;/ISSNLinking&gt;
  322. &lt;/MedlineJournalInfo&gt;
  323. &lt;/MedlineCitation&gt;
  324. &lt;PubmedData&gt;
  325. &lt;History&gt;
  326. &lt;PubMedPubDate PubStatus="received"&gt;
  327. &lt;Year&gt;2012&lt;/Year&gt;
  328. &lt;Month&gt;11&lt;/Month&gt;
  329. &lt;Day&gt;15&lt;/Day&gt;
  330. &lt;/PubMedPubDate&gt;
  331. &lt;PubMedPubDate PubStatus="revised"&gt;
  332. &lt;Year&gt;2012&lt;/Year&gt;
  333. &lt;Month&gt;12&lt;/Month&gt;
  334. &lt;Day&gt;29&lt;/Day&gt;
  335. &lt;/PubMedPubDate&gt;
  336. &lt;PubMedPubDate PubStatus="accepted"&gt;
  337. &lt;Year&gt;2013&lt;/Year&gt;
  338. &lt;Month&gt;1&lt;/Month&gt;
  339. &lt;Day&gt;2&lt;/Day&gt;
  340. &lt;/PubMedPubDate&gt;
  341. &lt;PubMedPubDate PubStatus="entrez"&gt;
  342. &lt;Year&gt;2013&lt;/Year&gt;
  343. &lt;Month&gt;1&lt;/Month&gt;
  344. &lt;Day&gt;15&lt;/Day&gt;
  345. &lt;Hour&gt;6&lt;/Hour&gt;
  346. &lt;Minute&gt;0&lt;/Minute&gt;
  347. &lt;/PubMedPubDate&gt;
  348. &lt;PubMedPubDate PubStatus="pubmed"&gt;
  349. &lt;Year&gt;2013&lt;/Year&gt;
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  366. &lt;ArticleId IdType="doi"&gt;10.1016/j.ijpsycho.2013.01.002&lt;/ArticleId&gt;
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  376. &lt;DateCreated&gt;
  377. &lt;Year&gt;2013&lt;/Year&gt;
  378. &lt;Month&gt;1&lt;/Month&gt;
  379. &lt;Day&gt;14&lt;/Day&gt;
  380. &lt;/DateCreated&gt;
  381. &lt;Article PubModel="Print-Electronic"&gt;
  382. &lt;Journal&gt;
  383. &lt;ISSN IssnType="Electronic"&gt;1873-3492&lt;/ISSN&gt;
  384. &lt;JournalIssue CitedMedium="Internet"&gt;
  385. &lt;PubDate&gt;
  386. &lt;Year&gt;2013&lt;/Year&gt;
  387. &lt;Month&gt;Jan&lt;/Month&gt;
  388. &lt;Day&gt;8&lt;/Day&gt;
  389. &lt;/PubDate&gt;
  390. &lt;/JournalIssue&gt;
  391. &lt;Title&gt;Clinica chimica acta; international journal of clinical chemistry&lt;/Title&gt;
  392. &lt;ISOAbbreviation&gt;Clin. Chim. Acta&lt;/ISOAbbreviation&gt;
  393. &lt;/Journal&gt;
  394. &lt;ArticleTitle&gt;Simultaneous liquid chromatography tandem mass spectrometric determination of urinary free metanephrines and catecholamines, with comparisons of free and deconjugated metabolites.&lt;/ArticleTitle&gt;
  395. &lt;Pagination&gt;
  396. &lt;MedlinePgn/&gt;
  397. &lt;/Pagination&gt;
  398. &lt;ELocationID EIdType="pii"&gt;S0009-8981(13)00013-2&lt;/ELocationID&gt;
  399. &lt;ELocationID EIdType="doi"&gt;10.1016/j.cca.2012.12.031&lt;/ELocationID&gt;
  400. &lt;Abstract&gt;
  401. &lt;AbstractText&gt;OBJECTIVE: We introduce a novel liquid chromatographic tandem-mass spectrometric method for simultaneous measurements of urinary catecholamines and their free O-methylated metabolites, which we compare to the deconjugated metabolites. METHODS: Method performance was validated for recovery, linearity, precision and accuracy, analyte stability, ion suppression and carry over. Results from 53 patients with and 138 volunteers without pheochromocytoma were compared. RESULTS: Analyte recoveries ranged from 60 to 96% and intra- and inter-assay coefficients of variation from 2.7 to 13.2%. The method showed excellent linearity over 3 orders of magnitude with analytical sensitivity sufficient to measure to 1.2 nmol/L. Free O-methylated metabolites were excreted at less than 20% the rates of the deconjugated metabolites, but were easily measureable. Increases in urinary normetanephrine in pheochromocytoma patients relative to volunteers were higher for free than deconjugated metabolites and higher for both than for norepinephrine (10 vs 5.5 vs 3.7 fold increases). In contrast, relative increases in urinary free versus deconjugated metanephrine (2.7 and 3.2) and methoxytyramine (2.1 and 1.9) did not differ, but for methoxytyramine were larger than for dopamine (1.2). CONCLUSION: Measurements of urinary catecholamines and their free O-methylated metabolites by our method provide potential advantages over urinary deconjugated metanephrines for diagnosis of pheochromocytoma.&lt;/AbstractText&gt;
  402. &lt;CopyrightInformation&gt;Copyright © 2012. Published by Elsevier B.V.&lt;/CopyrightInformation&gt;
  403. &lt;/Abstract&gt;
  404. &lt;Affiliation&gt;Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus at the TU Dresden, Fetscherstrasse 74, D-01307 Dresden, Germany. Electronic address: Mirko.Peitzsch@uniklinikum-dresden.de.&lt;/Affiliation&gt;
  405. &lt;AuthorList&gt;
  406. &lt;Author&gt;
  407. &lt;LastName&gt;Peitzsch&lt;/LastName&gt;
  408. &lt;ForeName&gt;Mirko&lt;/ForeName&gt;
  409. &lt;Initials&gt;M&lt;/Initials&gt;
  410. &lt;/Author&gt;
  411. &lt;Author&gt;
  412. &lt;LastName&gt;Pelzel&lt;/LastName&gt;
  413. &lt;ForeName&gt;Daniela&lt;/ForeName&gt;
  414. &lt;Initials&gt;D&lt;/Initials&gt;
  415. &lt;/Author&gt;
  416. &lt;Author&gt;
  417. &lt;LastName&gt;Glöckner&lt;/LastName&gt;
  418. &lt;ForeName&gt;Stephan&lt;/ForeName&gt;
  419. &lt;Initials&gt;S&lt;/Initials&gt;
  420. &lt;/Author&gt;
  421. &lt;Author&gt;
  422. &lt;LastName&gt;Prejbisz&lt;/LastName&gt;
  423. &lt;ForeName&gt;Aleksander&lt;/ForeName&gt;
  424. &lt;Initials&gt;A&lt;/Initials&gt;
  425. &lt;/Author&gt;
  426. &lt;Author&gt;
  427. &lt;LastName&gt;Fassnacht&lt;/LastName&gt;
  428. &lt;ForeName&gt;Martin&lt;/ForeName&gt;
  429. &lt;Initials&gt;M&lt;/Initials&gt;
  430. &lt;/Author&gt;
  431. &lt;Author&gt;
  432. &lt;LastName&gt;Beuschlein&lt;/LastName&gt;
  433. &lt;ForeName&gt;Felix&lt;/ForeName&gt;
  434. &lt;Initials&gt;F&lt;/Initials&gt;
  435. &lt;/Author&gt;
  436. &lt;Author&gt;
  437. &lt;LastName&gt;Januszewicz&lt;/LastName&gt;
  438. &lt;ForeName&gt;Andrzej&lt;/ForeName&gt;
  439. &lt;Initials&gt;A&lt;/Initials&gt;
  440. &lt;/Author&gt;
  441. &lt;Author&gt;
  442. &lt;LastName&gt;Siegert&lt;/LastName&gt;
  443. &lt;ForeName&gt;Gabriele&lt;/ForeName&gt;
  444. &lt;Initials&gt;G&lt;/Initials&gt;
  445. &lt;/Author&gt;
  446. &lt;Author&gt;
  447. &lt;LastName&gt;Eisenhofer&lt;/LastName&gt;
  448. &lt;ForeName&gt;Graeme&lt;/ForeName&gt;
  449. &lt;Initials&gt;G&lt;/Initials&gt;
  450. &lt;/Author&gt;
  451. &lt;/AuthorList&gt;
  452. &lt;Language&gt;ENG&lt;/Language&gt;
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  454. &lt;PublicationType&gt;JOURNAL ARTICLE&lt;/PublicationType&gt;
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  457. &lt;Year&gt;2013&lt;/Year&gt;
  458. &lt;Month&gt;1&lt;/Month&gt;
  459. &lt;Day&gt;8&lt;/Day&gt;
  460. &lt;/ArticleDate&gt;
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  463. &lt;MedlineTA&gt;Clin Chim Acta&lt;/MedlineTA&gt;
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  473. &lt;Day&gt;26&lt;/Day&gt;
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  478. &lt;Day&gt;3&lt;/Day&gt;
  479. &lt;/PubMedPubDate&gt;
  480. &lt;PubMedPubDate PubStatus="accepted"&gt;
  481. &lt;Year&gt;2012&lt;/Year&gt;
  482. &lt;Month&gt;12&lt;/Month&gt;
  483. &lt;Day&gt;27&lt;/Day&gt;
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  516.  
  517. &lt;PubmedArticle&gt;
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  519. &lt;PMID Version="1"&gt;23312734&lt;/PMID&gt;
  520. &lt;DateCreated&gt;
  521. &lt;Year&gt;2013&lt;/Year&gt;
  522. &lt;Month&gt;1&lt;/Month&gt;
  523. &lt;Day&gt;14&lt;/Day&gt;
  524. &lt;/DateCreated&gt;
  525. &lt;Article PubModel="Print-Electronic"&gt;
  526. &lt;Journal&gt;
  527. &lt;ISSN IssnType="Electronic"&gt;1879-1891&lt;/ISSN&gt;
  528. &lt;JournalIssue CitedMedium="Internet"&gt;
  529. &lt;PubDate&gt;
  530. &lt;Year&gt;2013&lt;/Year&gt;
  531. &lt;Month&gt;Jan&lt;/Month&gt;
  532. &lt;Day&gt;9&lt;/Day&gt;
  533. &lt;/PubDate&gt;
  534. &lt;/JournalIssue&gt;
  535. &lt;Title&gt;American journal of ophthalmology&lt;/Title&gt;
  536. &lt;ISOAbbreviation&gt;Am. J. Ophthalmol.&lt;/ISOAbbreviation&gt;
  537. &lt;/Journal&gt;
  538. &lt;ArticleTitle&gt;Macular Pseudoholes with Lamellar Cleavage of Their Edge Remain Pseudoholes.&lt;/ArticleTitle&gt;
  539. &lt;Pagination&gt;
  540. &lt;MedlinePgn/&gt;
  541. &lt;/Pagination&gt;
  542. &lt;ELocationID EIdType="pii"&gt;S0002-9394(12)00766-0&lt;/ELocationID&gt;
  543. &lt;ELocationID EIdType="doi"&gt;10.1016/j.ajo.2012.10.021&lt;/ELocationID&gt;
  544. &lt;Abstract&gt;
  545. &lt;AbstractText&gt;PURPOSE: To reappraise macular pseudohole characteristics using spectral-domain optical coherence tomography (OCT) and characteristics and postoperative outcomes of macular pseudoholes. DESIGN: Retrospective, observational case series. METHODS: In this institutional study, 54 eyes with macular pseudohole were selected among 369 patients examined for an epiretinal membrane (ERM) by Cirrus spectral-domain OCT (Carl Zeiss Meditec) within a 2-year period. The diagnosis of macular pseudohole was based on the presence of a deep foveal pit, with verticalized edges and a macula thickened by the contraction of an ERM. All eyes underwent color fundus photography and spectral-domain OCT examination comprising a macular map, line raster scans, and en face images of the inner retinal surface. The main outcome measures were the morphologic description of the foveal profile in macular pseudoholes in relation to the pattern of the ERM contraction and the postoperative changes. RESULTS: In 24 eyes, the foveal pit had vertical, straight, smooth edges on the OCT scan corresponding to centripetal contraction of the ERM. Thirty other eyes exhibited some degree of stretching and cleavage of the foveal pit edge resulting from asymmetrical tangential traction of the ERM between multiple epicenters of contraction. Thirty-three patients underwent surgery, and their macular profile and visual acuity improved whatever their initial foveal profile. CONCLUSIONS: The OCT profile of macular pseudohole varies according to the pattern of the causal ERM contraction. Macular pseudoholes with a stretched foveal edge respond to ERM peeling as positively as other eyes and should not be confounded with macular lamellar holes.&lt;/AbstractText&gt;
  546. &lt;CopyrightInformation&gt;Copyright © 2013 Elsevier Inc. All rights reserved.&lt;/CopyrightInformation&gt;
  547. &lt;/Abstract&gt;
  548. &lt;Affiliation&gt;Service d'Ophtalmologie, Hôpital Lariboisière APHP, Université Paris Diderot, Paris, France. Electronic address: alain.gaudric@lrb.aphp.fr.&lt;/Affiliation&gt;
  549. &lt;AuthorList&gt;
  550. &lt;Author&gt;
  551. &lt;LastName&gt;Gaudric&lt;/LastName&gt;
  552. &lt;ForeName&gt;Alain&lt;/ForeName&gt;
  553. &lt;Initials&gt;A&lt;/Initials&gt;
  554. &lt;/Author&gt;
  555. &lt;Author&gt;
  556. &lt;LastName&gt;Aloulou&lt;/LastName&gt;
  557. &lt;ForeName&gt;Yassine&lt;/ForeName&gt;
  558. &lt;Initials&gt;Y&lt;/Initials&gt;
  559. &lt;/Author&gt;
  560. &lt;Author&gt;
  561. &lt;LastName&gt;Tadayoni&lt;/LastName&gt;
  562. &lt;ForeName&gt;Ramin&lt;/ForeName&gt;
  563. &lt;Initials&gt;R&lt;/Initials&gt;
  564. &lt;/Author&gt;
  565. &lt;Author&gt;
  566. &lt;LastName&gt;Massin&lt;/LastName&gt;
  567. &lt;ForeName&gt;Pascale&lt;/ForeName&gt;
  568. &lt;Initials&gt;P&lt;/Initials&gt;
  569. &lt;/Author&gt;
  570. &lt;/AuthorList&gt;
  571. &lt;Language&gt;ENG&lt;/Language&gt;
  572. &lt;PublicationTypeList&gt;
  573. &lt;PublicationType&gt;JOURNAL ARTICLE&lt;/PublicationType&gt;
  574. &lt;/PublicationTypeList&gt;
  575. &lt;ArticleDate DateType="Electronic"&gt;
  576. &lt;Year&gt;2013&lt;/Year&gt;
  577. &lt;Month&gt;1&lt;/Month&gt;
  578. &lt;Day&gt;9&lt;/Day&gt;
  579. &lt;/ArticleDate&gt;
  580. &lt;/Article&gt;
  581. &lt;MedlineJournalInfo&gt;
  582. &lt;MedlineTA&gt;Am J Ophthalmol&lt;/MedlineTA&gt;
  583. &lt;NlmUniqueID&gt;0370500&lt;/NlmUniqueID&gt;
  584. &lt;ISSNLinking&gt;0002-9394&lt;/ISSNLinking&gt;
  585. &lt;/MedlineJournalInfo&gt;
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  590. &lt;Year&gt;2012&lt;/Year&gt;
  591. &lt;Month&gt;3&lt;/Month&gt;
  592. &lt;Day&gt;26&lt;/Day&gt;
  593. &lt;/PubMedPubDate&gt;
  594. &lt;PubMedPubDate PubStatus="revised"&gt;
  595. &lt;Year&gt;2012&lt;/Year&gt;
  596. &lt;Month&gt;10&lt;/Month&gt;
  597. &lt;Day&gt;24&lt;/Day&gt;
  598. &lt;/PubMedPubDate&gt;
  599. &lt;PubMedPubDate PubStatus="accepted"&gt;
  600. &lt;Year&gt;2012&lt;/Year&gt;
  601. &lt;Month&gt;10&lt;/Month&gt;
  602. &lt;Day&gt;25&lt;/Day&gt;
  603. &lt;/PubMedPubDate&gt;
  604. &lt;PubMedPubDate PubStatus="entrez"&gt;
  605. &lt;Year&gt;2013&lt;/Year&gt;
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  614. &lt;Day&gt;15&lt;/Day&gt;
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  619. &lt;Year&gt;2013&lt;/Year&gt;
  620. &lt;Month&gt;1&lt;/Month&gt;
  621. &lt;Day&gt;15&lt;/Day&gt;
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  629. &lt;ArticleId IdType="doi"&gt;10.1016/j.ajo.2012.10.021&lt;/ArticleId&gt;
  630. &lt;ArticleId IdType="pubmed"&gt;23312734&lt;/ArticleId&gt;
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  634.  
  635.  
  636. &lt;PubmedArticle&gt;
  637. &lt;MedlineCitation Owner="NLM" Status="In-Data-Review"&gt;
  638. &lt;PMID Version="1"&gt;19894140&lt;/PMID&gt;
  639. &lt;DateCreated&gt;
  640. &lt;Year&gt;2012&lt;/Year&gt;
  641. &lt;Month&gt;12&lt;/Month&gt;
  642. &lt;Day&gt;24&lt;/Day&gt;
  643. &lt;/DateCreated&gt;
  644. &lt;Article PubModel="Print-Electronic"&gt;
  645. &lt;Journal&gt;
  646. &lt;ISSN IssnType="Electronic"&gt;1573-2665&lt;/ISSN&gt;
  647. &lt;JournalIssue CitedMedium="Internet"&gt;
  648. &lt;Volume&gt;32 Suppl 1&lt;/Volume&gt;
  649. &lt;PubDate&gt;
  650. &lt;Year&gt;2009&lt;/Year&gt;
  651. &lt;Month&gt;Dec&lt;/Month&gt;
  652. &lt;/PubDate&gt;
  653. &lt;/JournalIssue&gt;
  654. &lt;Title&gt;Journal of inherited metabolic disease&lt;/Title&gt;
  655. &lt;ISOAbbreviation&gt;J. Inherit. Metab. Dis.&lt;/ISOAbbreviation&gt;
  656. &lt;/Journal&gt;
  657. &lt;ArticleTitle&gt;Scheie syndrome: Enzyme replacement therapy does not prevent progression of cervical myelopathy due to spinal cord compression.&lt;/ArticleTitle&gt;
  658. &lt;Pagination&gt;
  659. &lt;MedlinePgn&gt;321-5&lt;/MedlinePgn&gt;
  660. &lt;/Pagination&gt;
  661. &lt;ELocationID EIdType="doi" ValidYN="Y"&gt;10.1007/s10545-009-1265-y&lt;/ELocationID&gt;
  662. &lt;Abstract&gt;
  663. &lt;AbstractText&gt;Hurler-Scheie syndrome is caused by alpha-l-iduronidase deficiency. Enzyme replacement therapy (ERT) can improve physical capacity and reduces organomegaly. However, the effect on bradytrophic connective tissue is limited. As intravenously administered enzyme cannot cross the blood-brain barrier, the therapy of choice for the more severe Hurler syndrome is haematopoietic stem cell transplantation (HCT). In the more attenuated Scheie syndrome, neurological impairment is less severe; therefore, ERT may be appropriate to treat these patients. Information on long-term outcome in Scheie patients undergoing ERT is scarce. We report a 38-year-old female Scheie patient who has been on ERT for 8 years. While non-neurological symptoms improved, she developed paresthesias in her hands and feet and progressive pain in her legs. Somatosensory evoked potentials were abnormal, suggesting dysfunction of the dorsal funiculus and lemniscus medialis. After 6 years of ERT, a spinal MRI showed dural thickening at the upper cervical spine. These soft-tissue deposits are presumably due to the accumulation of mucopolysaccharides. Intramedullary hyperintensities at the level of C1/2 revealed cervical myelopathy. An MRI before the start of ERT had shown milder spinal lesions. Cystic lesions in the white matter of the centrum semiovale due to dilated Virchow-Robin spaces were essentially unchanged compared with the MRI scan before ERT. Decompression of the spinal cord resulted in clinical improvement. In an adult patient with Scheie syndrome, ERT failed to prevent progression of cervical myelopathy. Clinical significance of cerebral changes is unclear. Whether early HCT or intrathecal ERT could have prevented these lesions remains speculative.&lt;/AbstractText&gt;
  664. &lt;/Abstract&gt;
  665. &lt;Affiliation&gt;Department of Paediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany, Illsinger.Sabine@mh-hannover.de.&lt;/Affiliation&gt;
  666. &lt;AuthorList CompleteYN="Y"&gt;
  667. &lt;Author ValidYN="Y"&gt;
  668. &lt;LastName&gt;Illsinger&lt;/LastName&gt;
  669. &lt;ForeName&gt;S&lt;/ForeName&gt;
  670. &lt;Initials&gt;S&lt;/Initials&gt;
  671. &lt;/Author&gt;
  672. &lt;Author ValidYN="Y"&gt;
  673. &lt;LastName&gt;Lücke&lt;/LastName&gt;
  674. &lt;ForeName&gt;T&lt;/ForeName&gt;
  675. &lt;Initials&gt;T&lt;/Initials&gt;
  676. &lt;/Author&gt;
  677. &lt;Author ValidYN="Y"&gt;
  678. &lt;LastName&gt;Hartmann&lt;/LastName&gt;
  679. &lt;ForeName&gt;H&lt;/ForeName&gt;
  680. &lt;Initials&gt;H&lt;/Initials&gt;
  681. &lt;/Author&gt;
  682. &lt;Author ValidYN="Y"&gt;
  683. &lt;LastName&gt;Mengel&lt;/LastName&gt;
  684. &lt;ForeName&gt;E&lt;/ForeName&gt;
  685. &lt;Initials&gt;E&lt;/Initials&gt;
  686. &lt;/Author&gt;
  687. &lt;Author ValidYN="Y"&gt;
  688. &lt;LastName&gt;Müller-Forell&lt;/LastName&gt;
  689. &lt;ForeName&gt;W&lt;/ForeName&gt;
  690. &lt;Initials&gt;W&lt;/Initials&gt;
  691. &lt;/Author&gt;
  692. &lt;Author ValidYN="Y"&gt;
  693. &lt;LastName&gt;Donnerstag&lt;/LastName&gt;
  694. &lt;ForeName&gt;F&lt;/ForeName&gt;
  695. &lt;Initials&gt;F&lt;/Initials&gt;
  696. &lt;/Author&gt;
  697. &lt;Author ValidYN="Y"&gt;
  698. &lt;LastName&gt;Das&lt;/LastName&gt;
  699. &lt;ForeName&gt;A M&lt;/ForeName&gt;
  700. &lt;Initials&gt;AM&lt;/Initials&gt;
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  778. &lt;Year&gt;2013&lt;/Year&gt;
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  780. &lt;Day&gt;11&lt;/Day&gt;
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  784. &lt;ISSN IssnType="Electronic"&gt;1432-0584&lt;/ISSN&gt;
  785. &lt;JournalIssue CitedMedium="Internet"&gt;
  786. &lt;PubDate&gt;
  787. &lt;Year&gt;2013&lt;/Year&gt;
  788. &lt;Month&gt;Jan&lt;/Month&gt;
  789. &lt;Day&gt;10&lt;/Day&gt;
  790. &lt;/PubDate&gt;
  791. &lt;/JournalIssue&gt;
  792. &lt;Title&gt;Annals of hematology&lt;/Title&gt;
  793. &lt;ISOAbbreviation&gt;Ann. Hematol.&lt;/ISOAbbreviation&gt;
  794. &lt;/Journal&gt;
  795. &lt;ArticleTitle&gt;Cytological characterization of murine bone marrow and spleen hematopoietic compartments for improved assessment of toxicity in preclinical gene marking models.&lt;/ArticleTitle&gt;
  796. &lt;Pagination&gt;
  797. &lt;MedlinePgn/&gt;
  798. &lt;/Pagination&gt;
  799. &lt;Abstract&gt;
  800. &lt;AbstractText&gt;Gene therapy has proven its potential to cure diseases of the hematopoietic system, but potential adverse reactions related to insertional mutagenesis by integrating gene vectors and chromosomal instability in long-lived repopulating cells have emerged as a major limitation. Preclinical gene therapy in murine models is a powerful model for assessment of gene marking efficiency and adverse reactions. However, changes in the hematologic composition after transplantation with retrovirally modified hematopoietic stem cells have not been well investigated in large cohorts of animals by systematic cytological analyses. In the present study, cytological analyses of bone marrow and spleen were performed in a large cohort (n = 58) of C57BL/6J mice over an extended observation period after gene marking. Interestingly, we observed hematological malignancies in four out of 30 animals transplanted with dLNGFR (truncated form of the human p75 low-affinity nerve growth factor receptor) and tCD34 modified stem/progenitor cells. Our data demonstrate that cytological analysis provides important information for diagnosis of hematological disorders and thus should be included in preclinical studies and performed in each investigated animal. Together with histological analysis, flow cytometric analysis, and other analyses, the quality and predictive value of preclinical gene therapy studies will be improved.&lt;/AbstractText&gt;
  801. &lt;/Abstract&gt;
  802. &lt;Affiliation&gt;Institute of Experimental Hematology, OE6960, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.&lt;/Affiliation&gt;
  803. &lt;AuthorList&gt;
  804. &lt;Author&gt;
  805. &lt;LastName&gt;Yang&lt;/LastName&gt;
  806. &lt;ForeName&gt;Min&lt;/ForeName&gt;
  807. &lt;Initials&gt;M&lt;/Initials&gt;
  808. &lt;/Author&gt;
  809. &lt;Author&gt;
  810. &lt;LastName&gt;Büsche&lt;/LastName&gt;
  811. &lt;ForeName&gt;Guntram&lt;/ForeName&gt;
  812. &lt;Initials&gt;G&lt;/Initials&gt;
  813. &lt;/Author&gt;
  814. &lt;Author&gt;
  815. &lt;LastName&gt;Ganser&lt;/LastName&gt;
  816. &lt;ForeName&gt;Arnold&lt;/ForeName&gt;
  817. &lt;Initials&gt;A&lt;/Initials&gt;
  818. &lt;/Author&gt;
  819. &lt;Author&gt;
  820. &lt;LastName&gt;Li&lt;/LastName&gt;
  821. &lt;ForeName&gt;Zhixiong&lt;/ForeName&gt;
  822. &lt;Initials&gt;Z&lt;/Initials&gt;
  823. &lt;/Author&gt;
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  825. &lt;Language&gt;ENG&lt;/Language&gt;
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  830. &lt;Year&gt;2013&lt;/Year&gt;
  831. &lt;Month&gt;1&lt;/Month&gt;
  832. &lt;Day&gt;10&lt;/Day&gt;
  833. &lt;/ArticleDate&gt;
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  846. &lt;Day&gt;5&lt;/Day&gt;
  847. &lt;/PubMedPubDate&gt;
  848. &lt;PubMedPubDate PubStatus="accepted"&gt;
  849. &lt;Year&gt;2012&lt;/Year&gt;
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  851. &lt;Day&gt;8&lt;/Day&gt;
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  891. &lt;PMID Version="1"&gt;23307597&lt;/PMID&gt;
  892. &lt;DateCreated&gt;
  893. &lt;Year&gt;2013&lt;/Year&gt;
  894. &lt;Month&gt;1&lt;/Month&gt;
  895. &lt;Day&gt;11&lt;/Day&gt;
  896. &lt;/DateCreated&gt;
  897. &lt;Article PubModel="Print-Electronic"&gt;
  898. &lt;Journal&gt;
  899. &lt;ISSN IssnType="Electronic"&gt;1432-0584&lt;/ISSN&gt;
  900. &lt;JournalIssue CitedMedium="Internet"&gt;
  901. &lt;PubDate&gt;
  902. &lt;Year&gt;2013&lt;/Year&gt;
  903. &lt;Month&gt;Jan&lt;/Month&gt;
  904. &lt;Day&gt;10&lt;/Day&gt;
  905. &lt;/PubDate&gt;
  906. &lt;/JournalIssue&gt;
  907. &lt;Title&gt;Annals of hematology&lt;/Title&gt;
  908. &lt;ISOAbbreviation&gt;Ann. Hematol.&lt;/ISOAbbreviation&gt;
  909. &lt;/Journal&gt;
  910. &lt;ArticleTitle&gt;Morphology and quantitative composition of hematopoietic cells in murine bone marrow and spleen of healthy subjects.&lt;/ArticleTitle&gt;
  911. &lt;Pagination&gt;
  912. &lt;MedlinePgn/&gt;
  913. &lt;/Pagination&gt;
  914. &lt;Abstract&gt;
  915. &lt;AbstractText&gt;Laboratory mice play an outstanding role in modeling human development and disease. In contrast to human leukemia, the spleen is involved in almost all cases, and the bone marrow is only variably involved in murine models. Although mice have been used for medical research for over 100 years, there are only few reports with a small number of cases looking at morphology and quantitative composition of murine hematopoietic cells in the bone marrow of non-transplanted animals of most strains. To our knowledge, there is not even a single report describing the splenogram in C57BL/6J mice, one of the most commonly used strains for medical research. The present study illustrates the morphology of the hematopoietic cells in the bone marrow and spleen of non-treated C57BL/6J mice and establishes the murine myelogram from the largest healthy C57BL/6J cohort reported to date. Furthermore, we present the first murine splenogram described for C57BL/6J mice. Our study supports the acceptance of the presence of &amp;gt;5 % blast cells as providing clear evidence of abnormality in bone marrow like in humans. In addition, we are the first to show &amp;lt;1 % blast cells in the normal spleen. Interestingly, classical dysplastic changes were rare in normal healthy mice. Our study of the bone marrow and spleen of healthy non-transplanted animals provides reference ranges of each cell type and for the myeloid/erythroid ratio, which can be used to interpret preclinical gene therapy data, leukemogenesis, and hematopoiesis studies, and may improve the quality of such analyses.&lt;/AbstractText&gt;
  916. &lt;/Abstract&gt;
  917. &lt;Affiliation&gt;Institute of Experimental Hematology, Hannover Medical School, OE6960, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.&lt;/Affiliation&gt;
  918. &lt;AuthorList&gt;
  919. &lt;Author&gt;
  920. &lt;LastName&gt;Yang&lt;/LastName&gt;
  921. &lt;ForeName&gt;Min&lt;/ForeName&gt;
  922. &lt;Initials&gt;M&lt;/Initials&gt;
  923. &lt;/Author&gt;
  924. &lt;Author&gt;
  925. &lt;LastName&gt;Büsche&lt;/LastName&gt;
  926. &lt;ForeName&gt;Guntram&lt;/ForeName&gt;
  927. &lt;Initials&gt;G&lt;/Initials&gt;
  928. &lt;/Author&gt;
  929. &lt;Author&gt;
  930. &lt;LastName&gt;Ganser&lt;/LastName&gt;
  931. &lt;ForeName&gt;Arnold&lt;/ForeName&gt;
  932. &lt;Initials&gt;A&lt;/Initials&gt;
  933. &lt;/Author&gt;
  934. &lt;Author&gt;
  935. &lt;LastName&gt;Li&lt;/LastName&gt;
  936. &lt;ForeName&gt;Zhixiong&lt;/ForeName&gt;
  937. &lt;Initials&gt;Z&lt;/Initials&gt;
  938. &lt;/Author&gt;
  939. &lt;/AuthorList&gt;
  940. &lt;Language&gt;ENG&lt;/Language&gt;
  941. &lt;PublicationTypeList&gt;
  942. &lt;PublicationType&gt;JOURNAL ARTICLE&lt;/PublicationType&gt;
  943. &lt;/PublicationTypeList&gt;
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  945. &lt;Year&gt;2013&lt;/Year&gt;
  946. &lt;Month&gt;1&lt;/Month&gt;
  947. &lt;Day&gt;10&lt;/Day&gt;
  948. &lt;/ArticleDate&gt;
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  961. &lt;Day&gt;5&lt;/Day&gt;
  962. &lt;/PubMedPubDate&gt;
  963. &lt;PubMedPubDate PubStatus="accepted"&gt;
  964. &lt;Year&gt;2012&lt;/Year&gt;
  965. &lt;Month&gt;12&lt;/Month&gt;
  966. &lt;Day&gt;8&lt;/Day&gt;
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  1003.  
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  1006. &lt;PMID Version="1"&gt;23306525&lt;/PMID&gt;
  1007. &lt;DateCreated&gt;
  1008. &lt;Year&gt;2013&lt;/Year&gt;
  1009. &lt;Month&gt;1&lt;/Month&gt;
  1010. &lt;Day&gt;11&lt;/Day&gt;
  1011. &lt;/DateCreated&gt;
  1012. &lt;Article PubModel="Print-Electronic"&gt;
  1013. &lt;Journal&gt;
  1014. &lt;ISSN IssnType="Electronic"&gt;1433-0431&lt;/ISSN&gt;
  1015. &lt;JournalIssue CitedMedium="Internet"&gt;
  1016. &lt;PubDate&gt;
  1017. &lt;Year&gt;2013&lt;/Year&gt;
  1018. &lt;Month&gt;Jan&lt;/Month&gt;
  1019. &lt;Day&gt;11&lt;/Day&gt;
  1020. &lt;/PubDate&gt;
  1021. &lt;/JournalIssue&gt;
  1022. &lt;Title&gt;Der Orthopade&lt;/Title&gt;
  1023. &lt;ISOAbbreviation&gt;Orthopade&lt;/ISOAbbreviation&gt;
  1024. &lt;/Journal&gt;
  1025. &lt;ArticleTitle&gt;[Foot and ankle fractures in children.]&lt;/ArticleTitle&gt;
  1026. &lt;Pagination&gt;
  1027. &lt;MedlinePgn/&gt;
  1028. &lt;/Pagination&gt;
  1029. &lt;Abstract&gt;
  1030. &lt;AbstractText&gt;Ankle fractures are the most frequent factures of weight-bearing joints in children while fractures of the hindfoot and midfoot are rare. Metatarsal fractures make up the greatest portion of foot fractures in children and mostly heal uneventfully. Generally, the fracture severity increases with increasing age and the fracture patterns in adolescents resemble those in adults but transitional fractures of the distal tibial epiphysis in adolescents between 12 and 14 years of age are an exception. A subtle clinical and radiographic examination is necessary to detect the injury pattern and to discriminate fractures from accessory bones, juvenile avascular necrosis and apophyses. Computed tomography scanning is most useful to precisely evaluate the degree of injury, especially articular involvement and to allow precise planning of the operative approach. Except for the calcaneus and the metatarsals the bones of the foot and ankle do not display a significant potential for spontaneous correction during growth; therefore, open reduction and internal fixation is indicated in all displaced fractures if closed reduction does not yield a satisfying result in order to avoid relevant post-traumatic deformities.&lt;/AbstractText&gt;
  1031. &lt;/Abstract&gt;
  1032. &lt;Affiliation&gt;Klinik für Unfall- und Wiederherstellungschirurgie, Universitätsklinikum Carl Gustav Carus der TU Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland, stefan.rammelt@uniklinikum-dresden.de.&lt;/Affiliation&gt;
  1033. &lt;AuthorList&gt;
  1034. &lt;Author&gt;
  1035. &lt;LastName&gt;Rammelt&lt;/LastName&gt;
  1036. &lt;ForeName&gt;S&lt;/ForeName&gt;
  1037. &lt;Initials&gt;S&lt;/Initials&gt;
  1038. &lt;/Author&gt;
  1039. &lt;Author&gt;
  1040. &lt;LastName&gt;Schneiders&lt;/LastName&gt;
  1041. &lt;ForeName&gt;W&lt;/ForeName&gt;
  1042. &lt;Initials&gt;W&lt;/Initials&gt;
  1043. &lt;/Author&gt;
  1044. &lt;Author&gt;
  1045. &lt;LastName&gt;Fitze&lt;/LastName&gt;
  1046. &lt;ForeName&gt;G&lt;/ForeName&gt;
  1047. &lt;Initials&gt;G&lt;/Initials&gt;
  1048. &lt;/Author&gt;
  1049. &lt;Author&gt;
  1050. &lt;LastName&gt;Zwipp&lt;/LastName&gt;
  1051. &lt;ForeName&gt;H&lt;/ForeName&gt;
  1052. &lt;Initials&gt;H&lt;/Initials&gt;
  1053. &lt;/Author&gt;
  1054. &lt;/AuthorList&gt;
  1055. &lt;Language&gt;GER&lt;/Language&gt;
  1056. &lt;PublicationTypeList&gt;
  1057. &lt;PublicationType&gt;JOURNAL ARTICLE&lt;/PublicationType&gt;
  1058. &lt;/PublicationTypeList&gt;
  1059. &lt;VernacularTitle&gt;Frakturen des kindlichen Sprunggelenks und Fußes.&lt;/VernacularTitle&gt;
  1060. &lt;ArticleDate DateType="Electronic"&gt;
  1061. &lt;Year&gt;2013&lt;/Year&gt;
  1062. &lt;Month&gt;1&lt;/Month&gt;
  1063. &lt;Day&gt;11&lt;/Day&gt;
  1064. &lt;/ArticleDate&gt;
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  1067. &lt;MedlineTA&gt;Orthopade&lt;/MedlineTA&gt;
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  1073. &lt;History&gt;
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  1075. &lt;Year&gt;2013&lt;/Year&gt;
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  1109. &lt;Year&gt;2013&lt;/Year&gt;
  1110. &lt;Month&gt;1&lt;/Month&gt;
  1111. &lt;Day&gt;11&lt;/Day&gt;
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  1113. &lt;Article PubModel="Print-Electronic"&gt;
  1114. &lt;Journal&gt;
  1115. &lt;ISSN IssnType="Electronic"&gt;1361-6560&lt;/ISSN&gt;
  1116. &lt;JournalIssue CitedMedium="Internet"&gt;
  1117. &lt;Volume&gt;58&lt;/Volume&gt;
  1118. &lt;Issue&gt;3&lt;/Issue&gt;
  1119. &lt;PubDate&gt;
  1120. &lt;Year&gt;2013&lt;/Year&gt;
  1121. &lt;Month&gt;Jan&lt;/Month&gt;
  1122. &lt;Day&gt;10&lt;/Day&gt;
  1123. &lt;/PubDate&gt;
  1124. &lt;/JournalIssue&gt;
  1125. &lt;Title&gt;Physics in medicine and biology&lt;/Title&gt;
  1126. &lt;ISOAbbreviation&gt;Phys Med Biol&lt;/ISOAbbreviation&gt;
  1127. &lt;/Journal&gt;
  1128. &lt;ArticleTitle&gt;4D particle therapy PET simulation for moving targets irradiated with scanned ion beams.&lt;/ArticleTitle&gt;
  1129. &lt;Pagination&gt;
  1130. &lt;MedlinePgn&gt;513-533&lt;/MedlinePgn&gt;
  1131. &lt;/Pagination&gt;
  1132. &lt;Abstract&gt;
  1133. &lt;AbstractText&gt;Particle therapy positron emission tomography (PT-PET) allows for an in vivo and in situ verification of applied dose distributions in ion beam therapy. Since the dose distribution cannot be extracted directly from the β(+)-activity distribution gained from the PET scan the validation is done by means of a comparison between the reconstructed β(+)-activity distributions from a PT-PET measurement and from a PT-PET simulation. Thus, the simulation software for generating PET data predicted from the treatment planning is an essential part of the dose verification routine. For the dose monitoring of intra-fractionally moving target volumes the PET data simulation needs to be upgraded by using time resolved (4D) algorithms to account correctly for the motion dependent displacement of the positron emitters. Moreover, it has to consider the time dependent relative movement between target volume and scanned beam to simulate the accurate positron emitter distribution generated during irradiation. Such a simulation program is presented which properly proceeds with motion compensated dose delivery by scanned ion beams to intra-fractionally moving targets. By means of a preclinical phantom study it is demonstrated that even the sophisticated motion-mitigated beam delivery technique of range compensated target tracking can be handled correctly by this simulation code. The new program is widely based on the 3D PT-PET simulation program which had been developed at the Helmholtz-Zentrum Dresden-Rossendorf, Germany (HZDR) for application within a pilot project to simulate in-beam PET data for about 440 patients with static tumor entities irradiated at the former treatment facility of the GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany (GSI). A simulation example for a phantom geometry irradiated with a tracked (12)C-ion beam is presented for demonstrating the proper functionality of the program.&lt;/AbstractText&gt;
  1134. &lt;/Abstract&gt;
  1135. &lt;Affiliation&gt;OncoRay - National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, TU Dresden, Fetscherstraße 74, PF 41, D-01307 Dresden, Germany.&lt;/Affiliation&gt;
  1136. &lt;AuthorList&gt;
  1137. &lt;Author&gt;
  1138. &lt;LastName&gt;Laube&lt;/LastName&gt;
  1139. &lt;ForeName&gt;K&lt;/ForeName&gt;
  1140. &lt;Initials&gt;K&lt;/Initials&gt;
  1141. &lt;/Author&gt;
  1142. &lt;Author&gt;
  1143. &lt;LastName&gt;Menkel&lt;/LastName&gt;
  1144. &lt;ForeName&gt;S&lt;/ForeName&gt;
  1145. &lt;Initials&gt;S&lt;/Initials&gt;
  1146. &lt;/Author&gt;
  1147. &lt;Author&gt;
  1148. &lt;LastName&gt;Bert&lt;/LastName&gt;
  1149. &lt;ForeName&gt;C&lt;/ForeName&gt;
  1150. &lt;Initials&gt;C&lt;/Initials&gt;
  1151. &lt;/Author&gt;
  1152. &lt;Author&gt;
  1153. &lt;LastName&gt;Enghardt&lt;/LastName&gt;
  1154. &lt;ForeName&gt;W&lt;/ForeName&gt;
  1155. &lt;Initials&gt;W&lt;/Initials&gt;
  1156. &lt;/Author&gt;
  1157. &lt;Author&gt;
  1158. &lt;LastName&gt;Helmbrecht&lt;/LastName&gt;
  1159. &lt;ForeName&gt;S&lt;/ForeName&gt;
  1160. &lt;Initials&gt;S&lt;/Initials&gt;
  1161. &lt;/Author&gt;
  1162. &lt;Author&gt;
  1163. &lt;LastName&gt;Saito&lt;/LastName&gt;
  1164. &lt;ForeName&gt;N&lt;/ForeName&gt;
  1165. &lt;Initials&gt;N&lt;/Initials&gt;
  1166. &lt;/Author&gt;
  1167. &lt;Author&gt;
  1168. &lt;LastName&gt;Fiedler&lt;/LastName&gt;
  1169. &lt;ForeName&gt;F&lt;/ForeName&gt;
  1170. &lt;Initials&gt;F&lt;/Initials&gt;
  1171. &lt;/Author&gt;
  1172. &lt;/AuthorList&gt;
  1173. &lt;Language&gt;ENG&lt;/Language&gt;
  1174. &lt;PublicationTypeList&gt;
  1175. &lt;PublicationType&gt;JOURNAL ARTICLE&lt;/PublicationType&gt;
  1176. &lt;/PublicationTypeList&gt;
  1177. &lt;ArticleDate DateType="Electronic"&gt;
  1178. &lt;Year&gt;2013&lt;/Year&gt;
  1179. &lt;Month&gt;1&lt;/Month&gt;
  1180. &lt;Day&gt;10&lt;/Day&gt;
  1181. &lt;/ArticleDate&gt;
  1182. &lt;/Article&gt;
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  1184. &lt;MedlineTA&gt;Phys Med Biol&lt;/MedlineTA&gt;
  1185. &lt;NlmUniqueID&gt;0401220&lt;/NlmUniqueID&gt;
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  1224. &lt;PMID Version="1"&gt;23305773&lt;/PMID&gt;
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  1226. &lt;Year&gt;2013&lt;/Year&gt;
  1227. &lt;Month&gt;1&lt;/Month&gt;
  1228. &lt;Day&gt;14&lt;/Day&gt;
  1229. &lt;/DateCreated&gt;
  1230. &lt;Article PubModel="Print-Electronic"&gt;
  1231. &lt;Journal&gt;
  1232. &lt;ISSN IssnType="Electronic"&gt;1872-678X&lt;/ISSN&gt;
  1233. &lt;JournalIssue CitedMedium="Internet"&gt;
  1234. &lt;PubDate&gt;
  1235. &lt;Year&gt;2013&lt;/Year&gt;
  1236. &lt;Month&gt;Jan&lt;/Month&gt;
  1237. &lt;Day&gt;7&lt;/Day&gt;
  1238. &lt;/PubDate&gt;
  1239. &lt;/JournalIssue&gt;
  1240. &lt;Title&gt;Journal of neuroscience methods&lt;/Title&gt;
  1241. &lt;ISOAbbreviation&gt;J. Neurosci. Methods&lt;/ISOAbbreviation&gt;
  1242. &lt;/Journal&gt;
  1243. &lt;ArticleTitle&gt;SaBer DBS: A fully programmable, rechargeable, bilateral, charge-balanced preclinical microstimulator for long-term neural stimulation.&lt;/ArticleTitle&gt;
  1244. &lt;Pagination&gt;
  1245. &lt;MedlinePgn/&gt;
  1246. &lt;/Pagination&gt;
  1247. &lt;ELocationID EIdType="pii"&gt;S0165-0270(12)00475-X&lt;/ELocationID&gt;
  1248. &lt;ELocationID EIdType="doi"&gt;10.1016/j.jneumeth.2012.12.008&lt;/ELocationID&gt;
  1249. &lt;Abstract&gt;
  1250. &lt;AbstractText&gt;To effectively study the mechanisms by which deep brain stimulation (DBS) produces its therapeutic benefit and to evaluate new therapeutic indications, it is vital to administer DBS over an extended period of time in awake, freely behaving animals. To date multiple preclinical stimulators have been designed and described. However, these stimulators have failed to incorporate some of the design criteria necessary to provide a system analogous to those used clinically. Here we define these design criteria and propose an improved and complete preclinical DBS system. This system is fully programmable in frequency, pulse-width and current amplitude, has a rechargeable battery and delivers biphasic, charge-balanced output to two independent electrodes. The system has been optimized for either implantation or for use externally via attachment to rodent jackets.&lt;/AbstractText&gt;
  1251. &lt;CopyrightInformation&gt;Copyright © 2012 Elsevier B.V. All rights reserved.&lt;/CopyrightInformation&gt;
  1252. &lt;/Abstract&gt;
  1253. &lt;Affiliation&gt;Department of Neuroscience, University of Pittsburgh, PA 15260, United States; Department of Psychiatry and Psychology, University of Pittsburgh, PA 15260, United States; Bereich Experimentelle Psychiatrie, Universitäatsklinik Carl Gustav Carus an der Technischen Universität Dresden, Fetscherstrasse 74, D-01307 Dresden, Germany. Electronic address: sam.ewing@gmail.com.&lt;/Affiliation&gt;
  1254. &lt;AuthorList&gt;
  1255. &lt;Author&gt;
  1256. &lt;LastName&gt;Ewing&lt;/LastName&gt;
  1257. &lt;ForeName&gt;Samuel G&lt;/ForeName&gt;
  1258. &lt;Initials&gt;SG&lt;/Initials&gt;
  1259. &lt;/Author&gt;
  1260. &lt;Author&gt;
  1261. &lt;LastName&gt;Porr&lt;/LastName&gt;
  1262. &lt;ForeName&gt;Bernd&lt;/ForeName&gt;
  1263. &lt;Initials&gt;B&lt;/Initials&gt;
  1264. &lt;/Author&gt;
  1265. &lt;Author&gt;
  1266. &lt;LastName&gt;Riddell&lt;/LastName&gt;
  1267. &lt;ForeName&gt;John&lt;/ForeName&gt;
  1268. &lt;Initials&gt;J&lt;/Initials&gt;
  1269. &lt;/Author&gt;
  1270. &lt;Author&gt;
  1271. &lt;LastName&gt;Winter&lt;/LastName&gt;
  1272. &lt;ForeName&gt;Christine&lt;/ForeName&gt;
  1273. &lt;Initials&gt;C&lt;/Initials&gt;
  1274. &lt;/Author&gt;
  1275. &lt;Author&gt;
  1276. &lt;LastName&gt;Grace&lt;/LastName&gt;
  1277. &lt;ForeName&gt;Anthony A&lt;/ForeName&gt;
  1278. &lt;Initials&gt;AA&lt;/Initials&gt;
  1279. &lt;/Author&gt;
  1280. &lt;/AuthorList&gt;
  1281. &lt;Language&gt;ENG&lt;/Language&gt;
  1282. &lt;PublicationTypeList&gt;
  1283. &lt;PublicationType&gt;JOURNAL ARTICLE&lt;/PublicationType&gt;
  1284. &lt;/PublicationTypeList&gt;
  1285. &lt;ArticleDate DateType="Electronic"&gt;
  1286. &lt;Year&gt;2013&lt;/Year&gt;
  1287. &lt;Month&gt;1&lt;/Month&gt;
  1288. &lt;Day&gt;7&lt;/Day&gt;
  1289. &lt;/ArticleDate&gt;
  1290. &lt;/Article&gt;
  1291. &lt;MedlineJournalInfo&gt;
  1292. &lt;MedlineTA&gt;J Neurosci Methods&lt;/MedlineTA&gt;
  1293. &lt;NlmUniqueID&gt;7905558&lt;/NlmUniqueID&gt;
  1294. &lt;ISSNLinking&gt;0165-0270&lt;/ISSNLinking&gt;
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  1297. &lt;PubmedData&gt;
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  1300. &lt;Year&gt;2012&lt;/Year&gt;
  1301. &lt;Month&gt;10&lt;/Month&gt;
  1302. &lt;Day&gt;1&lt;/Day&gt;
  1303. &lt;/PubMedPubDate&gt;
  1304. &lt;PubMedPubDate PubStatus="revised"&gt;
  1305. &lt;Year&gt;2012&lt;/Year&gt;
  1306. &lt;Month&gt;12&lt;/Month&gt;
  1307. &lt;Day&gt;10&lt;/Day&gt;
  1308. &lt;/PubMedPubDate&gt;
  1309. &lt;PubMedPubDate PubStatus="accepted"&gt;
  1310. &lt;Year&gt;2012&lt;/Year&gt;
  1311. &lt;Month&gt;12&lt;/Month&gt;
  1312. &lt;Day&gt;11&lt;/Day&gt;
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  1339. &lt;ArticleId IdType="doi"&gt;10.1016/j.jneumeth.2012.12.008&lt;/ArticleId&gt;
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  1344.  
  1345.  
  1346. &lt;PubmedArticle&gt;
  1347. &lt;MedlineCitation Owner="NLM" Status="In-Data-Review"&gt;
  1348. &lt;PMID Version="1"&gt;23297901&lt;/PMID&gt;
  1349. &lt;DateCreated&gt;
  1350. &lt;Year&gt;2013&lt;/Year&gt;
  1351. &lt;Month&gt;01&lt;/Month&gt;
  1352. &lt;Day&gt;09&lt;/Day&gt;
  1353. &lt;/DateCreated&gt;
  1354. &lt;Article PubModel="Print"&gt;
  1355. &lt;Journal&gt;
  1356. &lt;ISSN IssnType="Electronic"&gt;1520-8524&lt;/ISSN&gt;
  1357. &lt;JournalIssue CitedMedium="Internet"&gt;
  1358. &lt;Volume&gt;133&lt;/Volume&gt;
  1359. &lt;Issue&gt;1&lt;/Issue&gt;
  1360. &lt;PubDate&gt;
  1361. &lt;Year&gt;2013&lt;/Year&gt;
  1362. &lt;Month&gt;Jan&lt;/Month&gt;
  1363. &lt;/PubDate&gt;
  1364. &lt;/JournalIssue&gt;
  1365. &lt;Title&gt;The Journal of the Acoustical Society of America&lt;/Title&gt;
  1366. &lt;ISOAbbreviation&gt;J. Acoust. Soc. Am.&lt;/ISOAbbreviation&gt;
  1367. &lt;/Journal&gt;
  1368. &lt;ArticleTitle&gt;Effects of spatial and temporal integration of a single early reflection on speech intelligibility.&lt;/ArticleTitle&gt;
  1369. &lt;Pagination&gt;
  1370. &lt;MedlinePgn&gt;269-82&lt;/MedlinePgn&gt;
  1371. &lt;/Pagination&gt;
  1372. &lt;ELocationID EIdType="doi" ValidYN="Y"&gt;10.1121/1.4768880&lt;/ELocationID&gt;
  1373. &lt;Abstract&gt;
  1374. &lt;AbstractText&gt;In order to study the interaction between the intelligibility advantage in rooms due to the presence of early reflections and due to binaural unmasking, a series of speech reception threshold experiments was performed employing a single reflection of the frontal target speech source as a function of its delay ranging from 0 to 200 ms. The direction of the reflection and the spatial characteristic of the interfering noise (diotic, diffuse, or laterally localized) were varied in the experiments. For the frontal reflection, full temporal integration was observed for all three noise types up to a delay of at least 25 ms followed by gradual intelligibility decay at longer delays. At 200 ms delay the reflection introduced additional intelligibility deterioration. For short delays, intelligibility was not reduced when the reflection was spatially separated from the direct sound in the diffuse and lateral noise conditions. A release from the deterioration effect at 200 ms delay was found for all spatially separated reflections. The suppression of a detrimental reflection was symmetrical in diffuse noise, but azimuth-dependent in lateral noise. This indicates an interaction of spatial and temporal processing of speech reflections which challenges existing binaural speech intelligibility models.&lt;/AbstractText&gt;
  1375. &lt;/Abstract&gt;
  1376. &lt;Affiliation&gt;Medical Physics, Institute of Physics, Carl-von-Ossietzky University Oldenburg, D-26111 Oldenburg, Germany.&lt;/Affiliation&gt;
  1377. &lt;AuthorList CompleteYN="Y"&gt;
  1378. &lt;Author ValidYN="Y"&gt;
  1379. &lt;LastName&gt;Warzybok&lt;/LastName&gt;
  1380. &lt;ForeName&gt;Anna&lt;/ForeName&gt;
  1381. &lt;Initials&gt;A&lt;/Initials&gt;
  1382. &lt;/Author&gt;
  1383. &lt;Author ValidYN="Y"&gt;
  1384. &lt;LastName&gt;Rennies&lt;/LastName&gt;
  1385. &lt;ForeName&gt;Jan&lt;/ForeName&gt;
  1386. &lt;Initials&gt;J&lt;/Initials&gt;
  1387. &lt;/Author&gt;
  1388. &lt;Author ValidYN="Y"&gt;
  1389. &lt;LastName&gt;Brand&lt;/LastName&gt;
  1390. &lt;ForeName&gt;Thomas&lt;/ForeName&gt;
  1391. &lt;Initials&gt;T&lt;/Initials&gt;
  1392. &lt;/Author&gt;
  1393. &lt;Author ValidYN="Y"&gt;
  1394. &lt;LastName&gt;Doclo&lt;/LastName&gt;
  1395. &lt;ForeName&gt;Simon&lt;/ForeName&gt;
  1396. &lt;Initials&gt;S&lt;/Initials&gt;
  1397. &lt;/Author&gt;
  1398. &lt;Author ValidYN="Y"&gt;
  1399. &lt;LastName&gt;Kollmeier&lt;/LastName&gt;
  1400. &lt;ForeName&gt;Birger&lt;/ForeName&gt;
  1401. &lt;Initials&gt;B&lt;/Initials&gt;
  1402. &lt;/Author&gt;
  1403. &lt;/AuthorList&gt;
  1404. &lt;Language&gt;eng&lt;/Language&gt;
  1405. &lt;PublicationTypeList&gt;
  1406. &lt;PublicationType&gt;Journal Article&lt;/PublicationType&gt;
  1407. &lt;/PublicationTypeList&gt;
  1408. &lt;/Article&gt;
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  1410. &lt;Country&gt;United States&lt;/Country&gt;
  1411. &lt;MedlineTA&gt;J Acoust Soc Am&lt;/MedlineTA&gt;
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  1413. &lt;ISSNLinking&gt;0001-4966&lt;/ISSNLinking&gt;
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  1420. &lt;Year&gt;2013&lt;/Year&gt;
  1421. &lt;Month&gt;1&lt;/Month&gt;
  1422. &lt;Day&gt;10&lt;/Day&gt;
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  1452. &lt;PMID Version="1"&gt;23297875&lt;/PMID&gt;
  1453. &lt;DateCreated&gt;
  1454. &lt;Year&gt;2013&lt;/Year&gt;
  1455. &lt;Month&gt;01&lt;/Month&gt;
  1456. &lt;Day&gt;09&lt;/Day&gt;
  1457. &lt;/DateCreated&gt;
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  1460. &lt;ISSN IssnType="Electronic"&gt;1520-8524&lt;/ISSN&gt;
  1461. &lt;JournalIssue CitedMedium="Internet"&gt;
  1462. &lt;Volume&gt;133&lt;/Volume&gt;
  1463. &lt;Issue&gt;1&lt;/Issue&gt;
  1464. &lt;PubDate&gt;
  1465. &lt;Year&gt;2013&lt;/Year&gt;
  1466. &lt;Month&gt;Jan&lt;/Month&gt;
  1467. &lt;/PubDate&gt;
  1468. &lt;/JournalIssue&gt;
  1469. &lt;Title&gt;The Journal of the Acoustical Society of America&lt;/Title&gt;
  1470. &lt;ISOAbbreviation&gt;J. Acoust. Soc. Am.&lt;/ISOAbbreviation&gt;
  1471. &lt;/Journal&gt;
  1472. &lt;ArticleTitle&gt;Comparing the effect of pause duration on threshold interaural time differences between exponential and squared-sine envelopes (L).&lt;/ArticleTitle&gt;
  1473. &lt;Pagination&gt;
  1474. &lt;MedlinePgn&gt;1-4&lt;/MedlinePgn&gt;
  1475. &lt;/Pagination&gt;
  1476. &lt;ELocationID EIdType="doi" ValidYN="Y"&gt;10.1121/1.4768876&lt;/ELocationID&gt;
  1477. &lt;Abstract&gt;
  1478. &lt;AbstractText&gt;Recently two studies [Klein-Hennig et al., J. Acoust. Soc. Am. 129, 3856-3872 (2011); Laback et al., J. Acoust. Soc. Am. 130, 1515-1529 (2011)] independently investigated the isolated effect of pause duration on sensitivity to interaural time differences (ITD) in the ongoing stimulus envelope. The steepness of the threshold ITD as a function of pause duration functions differed considerably across studies. The present study, using matched carrier and modulation frequencies, directly compared threshold ITDs for the two envelope flank shapes from those studies. The results agree well when defining the metric of pause duration based on modulation depth sensitivity.&lt;/AbstractText&gt;
  1479. &lt;/Abstract&gt;
  1480. &lt;Affiliation&gt;Medizinische Physik, Universität Oldenburg, Carl-von-Ossietzky Straße 9-11, 26111 Oldenburg, Germany.&lt;/Affiliation&gt;
  1481. &lt;AuthorList CompleteYN="Y"&gt;
  1482. &lt;Author ValidYN="Y"&gt;
  1483. &lt;LastName&gt;Dietz&lt;/LastName&gt;
  1484. &lt;ForeName&gt;Mathias&lt;/ForeName&gt;
  1485. &lt;Initials&gt;M&lt;/Initials&gt;
  1486. &lt;/Author&gt;
  1487. &lt;Author ValidYN="Y"&gt;
  1488. &lt;LastName&gt;Wendt&lt;/LastName&gt;
  1489. &lt;ForeName&gt;Torben&lt;/ForeName&gt;
  1490. &lt;Initials&gt;T&lt;/Initials&gt;
  1491. &lt;/Author&gt;
  1492. &lt;Author ValidYN="Y"&gt;
  1493. &lt;LastName&gt;Ewert&lt;/LastName&gt;
  1494. &lt;ForeName&gt;Stephan D&lt;/ForeName&gt;
  1495. &lt;Initials&gt;SD&lt;/Initials&gt;
  1496. &lt;/Author&gt;
  1497. &lt;Author ValidYN="Y"&gt;
  1498. &lt;LastName&gt;Laback&lt;/LastName&gt;
  1499. &lt;ForeName&gt;Bernhard&lt;/ForeName&gt;
  1500. &lt;Initials&gt;B&lt;/Initials&gt;
  1501. &lt;/Author&gt;
  1502. &lt;Author ValidYN="Y"&gt;
  1503. &lt;LastName&gt;Hohmann&lt;/LastName&gt;
  1504. &lt;ForeName&gt;Volker&lt;/ForeName&gt;
  1505. &lt;Initials&gt;V&lt;/Initials&gt;
  1506. &lt;/Author&gt;
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  1508. &lt;Language&gt;eng&lt;/Language&gt;
  1509. &lt;PublicationTypeList&gt;
  1510. &lt;PublicationType&gt;Journal Article&lt;/PublicationType&gt;
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  1514. &lt;Country&gt;United States&lt;/Country&gt;
  1515. &lt;MedlineTA&gt;J Acoust Soc Am&lt;/MedlineTA&gt;
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  1517. &lt;ISSNLinking&gt;0001-4966&lt;/ISSNLinking&gt;
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  1556. &lt;PMID Version="1"&gt;23297324&lt;/PMID&gt;
  1557. &lt;DateCreated&gt;
  1558. &lt;Year&gt;2013&lt;/Year&gt;
  1559. &lt;Month&gt;1&lt;/Month&gt;
  1560. &lt;Day&gt;8&lt;/Day&gt;
  1561. &lt;/DateCreated&gt;
  1562. &lt;Article PubModel="Print-Electronic"&gt;
  1563. &lt;Journal&gt;
  1564. &lt;ISSN IssnType="Electronic"&gt;1527-1315&lt;/ISSN&gt;
  1565. &lt;JournalIssue CitedMedium="Internet"&gt;
  1566. &lt;PubDate&gt;
  1567. &lt;Year&gt;2013&lt;/Year&gt;
  1568. &lt;Month&gt;Jan&lt;/Month&gt;
  1569. &lt;Day&gt;7&lt;/Day&gt;
  1570. &lt;/PubDate&gt;
  1571. &lt;/JournalIssue&gt;
  1572. &lt;Title&gt;Radiology&lt;/Title&gt;
  1573. &lt;ISOAbbreviation&gt;Radiology&lt;/ISOAbbreviation&gt;
  1574. &lt;/Journal&gt;
  1575. &lt;ArticleTitle&gt;Percutaneous Punctures with MR Imaging Guidance: Comparison between MR Imaging-enhanced Fluoroscopic Guidance and Real-time MR Imaging Guidance.&lt;/ArticleTitle&gt;
  1576. &lt;Pagination&gt;
  1577. &lt;MedlinePgn/&gt;
  1578. &lt;/Pagination&gt;
  1579. &lt;Abstract&gt;
  1580. &lt;AbstractText&gt;Purpose:To evaluate and compare the technical accuracy and feasibility of magnetic resonance (MR) imaging-enhanced fluoroscopic guidance and real-time MR imaging guidance for percutaneous puncture procedures in phantoms and animals.Materials and Methods:The experimental protocol was approved by the institutional animal care and use committee. Punctures were performed in phantoms, aiming for markers (20 each for MR imaging-enhanced fluoroscopic guidance and real-time MR imaging guidance), and pigs, aiming for anatomic landmarks (10 for MR imaging-enhanced fluoroscopic guidance and five for MR imaging guidance). To guide the punctures, T1-weighted three-dimensional (3D) MR images of the phantom or pig were acquired. Additional axial and coronal T2-weighted images were used to visualize the anatomy in the animals. For MR imaging-enhanced fluoroscopic guidance, phantoms and pigs were transferred to the fluoroscopic system after initial MR imaging and C-arm computed tomography (CT) was performed. C-arm CT and MR imaging data sets were coregistered. Prototype navigation software was used to plan a puncture path with use of MR images and to superimpose it on fluoroscopic images. For real-time MR imaging, an interventional MR imaging prototype for interactive real-time section position navigation was used. Punctures were performed within the magnet bore. After completion, 3D MR imaging was performed to evaluate the accuracy of insertions. Puncture durations were compared by using the log-rank test. The Mann-Whitney U test was applied to compare the spatial errors.Results:In phantoms, the mean total error was 8.6 mm ± 2.8 with MR imaging-enhanced fluoroscopic guidance and 4.0 mm ± 1.2 with real-time MR imaging guidance (P &amp;lt; .001). The mean puncture time was 2 minutes 10 seconds ± 44 seconds with MR imaging-enhanced fluoroscopic guidance and 37 seconds ± 14 with real-time MR imaging guidance (P &amp;lt; .001). In the animal study, a tolerable distance (&amp;lt;1 cm) between target and needle tip was observed for both MR imaging-enhanced fluoroscopic guidance and real-time MR imaging guidance. The mean total error was 7.7 mm ± 2.4 with MR imaging-enhanced fluoroscopic guidance and 7.9 mm ± 4.9 with real-time MR imaging guidance (P = .77). The mean puncture time was 5 minutes 43 seconds ± 2 minutes 7 seconds with MR imaging-enhanced fluoroscopic guidance and 5 minutes 14 seconds ± 2 minutes 25 seconds with real-time MR imaging guidance (P = .68).Conclusion:Both MR imaging-enhanced fluoroscopic guidance and real-time MR imaging guidance demonstrated reasonable and similar accuracy in guiding needle placement to selected targets in phantoms and animals.© RSNA, 2013Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12120117/-/DC1.&lt;/AbstractText&gt;
  1581. &lt;/Abstract&gt;
  1582. &lt;Affiliation&gt;Department of Radiology, Hannover Medical School, Carl-Neuberg-Str 1, 30625 Hannover, Germany; Pattern Recognition Laboratory, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany; The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md; Center for Applied Medical Imaging, Siemens Corporate Research, Baltimore, Md.&lt;/Affiliation&gt;
  1583. &lt;AuthorList&gt;
  1584. &lt;Author&gt;
  1585. &lt;LastName&gt;Meyer&lt;/LastName&gt;
  1586. &lt;ForeName&gt;Bernhard Christian&lt;/ForeName&gt;
  1587. &lt;Initials&gt;BC&lt;/Initials&gt;
  1588. &lt;/Author&gt;
  1589. &lt;Author&gt;
  1590. &lt;LastName&gt;Brost&lt;/LastName&gt;
  1591. &lt;ForeName&gt;Alexander&lt;/ForeName&gt;
  1592. &lt;Initials&gt;A&lt;/Initials&gt;
  1593. &lt;/Author&gt;
  1594. &lt;Author&gt;
  1595. &lt;LastName&gt;Kraitchman&lt;/LastName&gt;
  1596. &lt;ForeName&gt;Dara L&lt;/ForeName&gt;
  1597. &lt;Initials&gt;DL&lt;/Initials&gt;
  1598. &lt;/Author&gt;
  1599. &lt;Author&gt;
  1600. &lt;LastName&gt;Gilson&lt;/LastName&gt;
  1601. &lt;ForeName&gt;Wesley D&lt;/ForeName&gt;
  1602. &lt;Initials&gt;WD&lt;/Initials&gt;
  1603. &lt;/Author&gt;
  1604. &lt;Author&gt;
  1605. &lt;LastName&gt;Strobel&lt;/LastName&gt;
  1606. &lt;ForeName&gt;Norbert&lt;/ForeName&gt;
  1607. &lt;Initials&gt;N&lt;/Initials&gt;
  1608. &lt;/Author&gt;
  1609. &lt;Author&gt;
  1610. &lt;LastName&gt;Hornegger&lt;/LastName&gt;
  1611. &lt;ForeName&gt;Joachim&lt;/ForeName&gt;
  1612. &lt;Initials&gt;J&lt;/Initials&gt;
  1613. &lt;/Author&gt;
  1614. &lt;Author&gt;
  1615. &lt;LastName&gt;Lewin&lt;/LastName&gt;
  1616. &lt;ForeName&gt;Jonathan S&lt;/ForeName&gt;
  1617. &lt;Initials&gt;JS&lt;/Initials&gt;
  1618. &lt;/Author&gt;
  1619. &lt;Author&gt;
  1620. &lt;LastName&gt;Wacker&lt;/LastName&gt;
  1621. &lt;ForeName&gt;Frank K&lt;/ForeName&gt;
  1622. &lt;Initials&gt;FK&lt;/Initials&gt;
  1623. &lt;/Author&gt;
  1624. &lt;/AuthorList&gt;
  1625. &lt;Language&gt;ENG&lt;/Language&gt;
  1626. &lt;PublicationTypeList&gt;
  1627. &lt;PublicationType&gt;JOURNAL ARTICLE&lt;/PublicationType&gt;
  1628. &lt;/PublicationTypeList&gt;
  1629. &lt;ArticleDate DateType="Electronic"&gt;
  1630. &lt;Year&gt;2013&lt;/Year&gt;
  1631. &lt;Month&gt;1&lt;/Month&gt;
  1632. &lt;Day&gt;7&lt;/Day&gt;
  1633. &lt;/ArticleDate&gt;
  1634. &lt;/Article&gt;
  1635. &lt;MedlineJournalInfo&gt;
  1636. &lt;MedlineTA&gt;Radiology&lt;/MedlineTA&gt;
  1637. &lt;NlmUniqueID&gt;0401260&lt;/NlmUniqueID&gt;
  1638. &lt;ISSNLinking&gt;0033-8419&lt;/ISSNLinking&gt;
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  1644. &lt;Year&gt;2013&lt;/Year&gt;
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  1658. &lt;Year&gt;2013&lt;/Year&gt;
  1659. &lt;Month&gt;1&lt;/Month&gt;
  1660. &lt;Day&gt;9&lt;/Day&gt;
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  1667. &lt;ArticleId IdType="pii"&gt;radiol.12120117&lt;/ArticleId&gt;
  1668. &lt;ArticleId IdType="doi"&gt;10.1148/radiol.12120117&lt;/ArticleId&gt;
  1669. &lt;ArticleId IdType="pubmed"&gt;23297324&lt;/ArticleId&gt;
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  1674.  
  1675. &lt;PubmedArticle&gt;
  1676. &lt;MedlineCitation Status="Publisher" Owner="NLM"&gt;
  1677. &lt;PMID Version="1"&gt;23296371&lt;/PMID&gt;
  1678. &lt;DateCreated&gt;
  1679. &lt;Year&gt;2013&lt;/Year&gt;
  1680. &lt;Month&gt;1&lt;/Month&gt;
  1681. &lt;Day&gt;8&lt;/Day&gt;
  1682. &lt;/DateCreated&gt;
  1683. &lt;Article PubModel="Print-Electronic"&gt;
  1684. &lt;Journal&gt;
  1685. &lt;ISSN IssnType="Electronic"&gt;1536-481X&lt;/ISSN&gt;
  1686. &lt;JournalIssue CitedMedium="Internet"&gt;
  1687. &lt;PubDate&gt;
  1688. &lt;Year&gt;2013&lt;/Year&gt;
  1689. &lt;Month&gt;Jan&lt;/Month&gt;
  1690. &lt;Day&gt;3&lt;/Day&gt;
  1691. &lt;/PubDate&gt;
  1692. &lt;/JournalIssue&gt;
  1693. &lt;Title&gt;Journal of glaucoma&lt;/Title&gt;
  1694. &lt;ISOAbbreviation&gt;J. Glaucoma&lt;/ISOAbbreviation&gt;
  1695. &lt;/Journal&gt;
  1696. &lt;ArticleTitle&gt;Optic Disc and Retinal Nerve Fiber Layer Thickness Descriptive Analysis in Megalopapilla.&lt;/ArticleTitle&gt;
  1697. &lt;Pagination&gt;
  1698. &lt;MedlinePgn/&gt;
  1699. &lt;/Pagination&gt;
  1700. &lt;Abstract&gt;
  1701. &lt;AbstractText&gt;PURPOSE:: To evaluate the optic disc and retinal nerve fiber layer (RNFL) thickness in megalopapilla cases by confocal scanning laser ophthalmoscopy and Stratus optical coherence tomography (OCT). To assess the importance of these measurements in diagnosing megalopapilla. METHODS:: This study included 59 eyes (30 patients) diagnosed as megalopapilla. All subjects underwent a complete ophthalmic examination that included intraocular pressure and central corneal thickness measurements and standard automated perimetry using the Swedish Interactive Threshold Algorithm and the 24-2 program (Humphrey Field Analyzer; Carl Zeiss Meditec Inc., Dublin, CA). Confocal scanning laser ophthalmoscopy examinations were performed with the Heidelberg retina tomograph (HRTII; Heidelberg Engineering, Germany). Thickness of the RNFL around the optic disc was measured with Stratus OCT, version 4.0.1 (Stratus OCT; Carl Zeiss Meditec). A descriptive analysis was made using SPSS (version 12.0; SPSS Inc., Chicago, IL) statistical software. RESULTS:: The mean global optic disc area for all eyes with megalopapilla was 3.28±0.53 mm and was not statistically different among races (P≥0.159) or sex (P≥0.108). The average RNFL thickness was 102.5±12.68 μm. Pattern standard deviation was 3.8±2.4 and mean deviation was -1.22±2.65. Central corneal thickness mean value was 543±35.9 μm. Intraocular pressure measurements ranged from 10.0 to 20.6 mm Hg (14.4±2.7). CONCLUSIONS:: In megalopapilla, the optic disc is abnormally large. The RNFL thickness is normal. These findings are essential for distinguishing megalopapilla from the optic glaucomatous neuropathy.&lt;/AbstractText&gt;
  1702. &lt;/Abstract&gt;
  1703. &lt;Affiliation&gt;Department of Ophthalmology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.&lt;/Affiliation&gt;
  1704. &lt;AuthorList&gt;
  1705. &lt;Author&gt;
  1706. &lt;LastName&gt;da Costa&lt;/LastName&gt;
  1707. &lt;ForeName&gt;Alinne M Camargos&lt;/ForeName&gt;
  1708. &lt;Initials&gt;AM&lt;/Initials&gt;
  1709. &lt;/Author&gt;
  1710. &lt;Author&gt;
  1711. &lt;LastName&gt;Cronemberger&lt;/LastName&gt;
  1712. &lt;ForeName&gt;Sebastião&lt;/ForeName&gt;
  1713. &lt;Initials&gt;S&lt;/Initials&gt;
  1714. &lt;/Author&gt;
  1715. &lt;/AuthorList&gt;
  1716. &lt;Language&gt;ENG&lt;/Language&gt;
  1717. &lt;PublicationTypeList&gt;
  1718. &lt;PublicationType&gt;JOURNAL ARTICLE&lt;/PublicationType&gt;
  1719. &lt;/PublicationTypeList&gt;
  1720. &lt;ArticleDate DateType="Electronic"&gt;
  1721. &lt;Year&gt;2013&lt;/Year&gt;
  1722. &lt;Month&gt;1&lt;/Month&gt;
  1723. &lt;Day&gt;3&lt;/Day&gt;
  1724. &lt;/ArticleDate&gt;
  1725. &lt;/Article&gt;
  1726. &lt;MedlineJournalInfo&gt;
  1727. &lt;MedlineTA&gt;J Glaucoma&lt;/MedlineTA&gt;
  1728. &lt;NlmUniqueID&gt;9300903&lt;/NlmUniqueID&gt;
  1729. &lt;ISSNLinking&gt;1057-0829&lt;/ISSNLinking&gt;
  1730. &lt;/MedlineJournalInfo&gt;
  1731. &lt;/MedlineCitation&gt;
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  1735. &lt;Year&gt;2013&lt;/Year&gt;
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  1744. &lt;Day&gt;9&lt;/Day&gt;
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  1749. &lt;Year&gt;2013&lt;/Year&gt;
  1750. &lt;Month&gt;1&lt;/Month&gt;
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  1769. &lt;Year&gt;2013&lt;/Year&gt;
  1770. &lt;Month&gt;1&lt;/Month&gt;
  1771. &lt;Day&gt;14&lt;/Day&gt;
  1772. &lt;/DateCreated&gt;
  1773. &lt;Article PubModel="Print-Electronic"&gt;
  1774. &lt;Journal&gt;
  1775. &lt;ISSN IssnType="Electronic"&gt;1095-8274&lt;/ISSN&gt;
  1776. &lt;JournalIssue CitedMedium="Internet"&gt;
  1777. &lt;PubDate&gt;
  1778. &lt;Year&gt;2013&lt;/Year&gt;
  1779. &lt;Month&gt;Jan&lt;/Month&gt;
  1780. &lt;Day&gt;4&lt;/Day&gt;
  1781. &lt;/PubDate&gt;
  1782. &lt;/JournalIssue&gt;
  1783. &lt;Title&gt;Anaerobe&lt;/Title&gt;
  1784. &lt;ISOAbbreviation&gt;Anaerobe&lt;/ISOAbbreviation&gt;
  1785. &lt;/Journal&gt;
  1786. &lt;ArticleTitle&gt;The changing faces of Clostridium difficile: A personal reflection of the past 34 years.&lt;/ArticleTitle&gt;
  1787. &lt;Pagination&gt;
  1788. &lt;MedlinePgn/&gt;
  1789. &lt;/Pagination&gt;
  1790. &lt;ELocationID EIdType="pii"&gt;S1075-9964(12)00174-6&lt;/ELocationID&gt;
  1791. &lt;ELocationID EIdType="doi"&gt;10.1016/j.anaerobe.2012.12.006&lt;/ELocationID&gt;
  1792. &lt;Abstract&gt;
  1793. &lt;AbstractText&gt;Late in 1978 my boss gave me a folder with &amp;quot;Clostridium difficile (diffikilé)&amp;quot; written on it. Inside were a few recent and now classic papers by Bartlett, Larson and co. It was suggested that this might be an interesting research topic. So began a continuing adventure which has resulted in at least 50 publications from my group. Over the years we have made several important contributions to the field. Beginning in 1982 we showed that C. difficile was a common cause of community-acquired infection! During the next few years we did extensive structural studies on the bacterium. This culminated in 1984 with a fingerprinting study (by immunoblotting surface antigens), on Swedish strains supplied by Carl-Erik Nord, which was probably the first study to demonstrate that C. difficile was really an infectious agent. This was later reinforced with strains sent from Amsterdam by Ed Kuijper. Later in the 1980s, in a study of recurrent disease, we showed that ca. 50% of recurrences were due to infection with a different strain. During my term as chair of the European Study Group for C. difficile, we began to define the status of C. difficile infection (CDI) in Europe and develop guidance for diagnosis and treatment. Recently we utilised our extensive culture collection, with isolates from the 1970s to the present, to observe how epidemiology has been driven largely by antibiotic usage. We have now come full circle: in the early years C. difficile infection was caused by many different strains. Then in the period beginning in the 1990s, characterised by often-large outbreaks and poor infection control, disease was caused by a few endemic strains highlighted by the 027/NAP1/BI pandemic. Now in a much-improved local situation, we are seeing again that the majority of cases (largely sporadic) is caused by multiple types. Current studies range from molecular studies on toxin and spore production, immune responses, novel observations on CDI in children, to what is the best way of decontaminating the anaerobe laboratory.&lt;/AbstractText&gt;
  1794. &lt;CopyrightInformation&gt;Copyright © 2013. Published by Elsevier Ltd.&lt;/CopyrightInformation&gt;
  1795. &lt;/Abstract&gt;
  1796. &lt;Affiliation&gt;Medical Microbiology, University of Edinburgh College of Medicine and Veterinary Medicine, Edinburgh, EH16 4SB, UK. Electronic address: i.r.poxton@ed.ac.uk.&lt;/Affiliation&gt;
  1797. &lt;AuthorList&gt;
  1798. &lt;Author&gt;
  1799. &lt;LastName&gt;Poxton&lt;/LastName&gt;
  1800. &lt;ForeName&gt;Ian R&lt;/ForeName&gt;
  1801. &lt;Initials&gt;IR&lt;/Initials&gt;
  1802. &lt;/Author&gt;
  1803. &lt;/AuthorList&gt;
  1804. &lt;Language&gt;ENG&lt;/Language&gt;
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  1809. &lt;Year&gt;2013&lt;/Year&gt;
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  1868. &lt;Year&gt;2013&lt;/Year&gt;
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  1870. &lt;Day&gt;8&lt;/Day&gt;
  1871. &lt;/DateCreated&gt;
  1872. &lt;Article PubModel="Print-Electronic"&gt;
  1873. &lt;Journal&gt;
  1874. &lt;ISSN IssnType="Electronic"&gt;1759-5053&lt;/ISSN&gt;
  1875. &lt;JournalIssue CitedMedium="Internet"&gt;
  1876. &lt;PubDate&gt;
  1877. &lt;Year&gt;2013&lt;/Year&gt;
  1878. &lt;Month&gt;Jan&lt;/Month&gt;
  1879. &lt;Day&gt;8&lt;/Day&gt;
  1880. &lt;/PubDate&gt;
  1881. &lt;/JournalIssue&gt;
  1882. &lt;Title&gt;Nature reviews. Gastroenterology &amp;amp; hepatology&lt;/Title&gt;
  1883. &lt;ISOAbbreviation&gt;Nat Rev Gastroenterol Hepatol&lt;/ISOAbbreviation&gt;
  1884. &lt;/Journal&gt;
  1885. &lt;ArticleTitle&gt;Hepatitis C in 2012: On the fast track towards IFN-free therapy for hepatitis C?&lt;/ArticleTitle&gt;
  1886. &lt;Pagination&gt;
  1887. &lt;MedlinePgn/&gt;
  1888. &lt;/Pagination&gt;
  1889. &lt;ELocationID EIdType="doi"&gt;10.1038/nrgastro.2012.247&lt;/ELocationID&gt;
  1890. &lt;Affiliation&gt;Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Street, Hannover 30625, Germany. wedemeyer.heiner@mh-hannover.de.&lt;/Affiliation&gt;
  1891. &lt;AuthorList&gt;
  1892. &lt;Author&gt;
  1893. &lt;LastName&gt;Wedemeyer&lt;/LastName&gt;
  1894. &lt;ForeName&gt;Heiner&lt;/ForeName&gt;
  1895. &lt;Initials&gt;H&lt;/Initials&gt;
  1896. &lt;/Author&gt;
  1897. &lt;/AuthorList&gt;
  1898. &lt;Language&gt;ENG&lt;/Language&gt;
  1899. &lt;PublicationTypeList&gt;
  1900. &lt;PublicationType&gt;JOURNAL ARTICLE&lt;/PublicationType&gt;
  1901. &lt;/PublicationTypeList&gt;
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  1903. &lt;Year&gt;2013&lt;/Year&gt;
  1904. &lt;Month&gt;1&lt;/Month&gt;
  1905. &lt;Day&gt;08&lt;/Day&gt;
  1906. &lt;/ArticleDate&gt;
  1907. &lt;/Article&gt;
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  1952.  
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  1955. &lt;PMID Version="1"&gt;23296147&lt;/PMID&gt;
  1956. &lt;DateCreated&gt;
  1957. &lt;Year&gt;2013&lt;/Year&gt;
  1958. &lt;Month&gt;1&lt;/Month&gt;
  1959. &lt;Day&gt;8&lt;/Day&gt;
  1960. &lt;/DateCreated&gt;
  1961. &lt;Article PubModel="Print-Electronic"&gt;
  1962. &lt;Journal&gt;
  1963. &lt;ISSN IssnType="Electronic"&gt;1534-6080&lt;/ISSN&gt;
  1964. &lt;JournalIssue CitedMedium="Internet"&gt;
  1965. &lt;PubDate&gt;
  1966. &lt;Year&gt;2013&lt;/Year&gt;
  1967. &lt;Month&gt;Jan&lt;/Month&gt;
  1968. &lt;Day&gt;4&lt;/Day&gt;
  1969. &lt;/PubDate&gt;
  1970. &lt;/JournalIssue&gt;
  1971. &lt;Title&gt;Transplantation&lt;/Title&gt;
  1972. &lt;ISOAbbreviation&gt;Transplantation&lt;/ISOAbbreviation&gt;
  1973. &lt;/Journal&gt;
  1974. &lt;ArticleTitle&gt;Risk Factors and Prognosis in T-Cell Posttransplantation Lymphoproliferative Diseases: Reevaluation of 163 Cases.&lt;/ArticleTitle&gt;
  1975. &lt;Pagination&gt;
  1976. &lt;MedlinePgn/&gt;
  1977. &lt;/Pagination&gt;
  1978. &lt;Abstract&gt;
  1979. &lt;AbstractText&gt;BACKGROUND: Posttransplantation lymphoproliferative diseases (PTLD) are mainly Epstein-Barr virus (EBV)-associated disorders of B-cell origin. Due to the rarity of monomorphic T-cell PTLD (T-PTLD), knowledge about pathogenesis, risk factors, therapy, and prognosis relies predominantly on case reports and small series. Therefore, we aimed to provide an overview and a retrospective analysis of this rare PTLD subtype. METHODS: We analyzed all available articles on T-PTLD in the PubMed database as well as in our own databases (Institute of Pathology/Department of Paediatric Haematology and Oncology, Hannover Medical School) from 1988 to 2010. Reevaluated parameters were gender, age, transplanted organ, immunosuppressant regimen, time between transplantation and T-PTLD manifestation, T-PTLD subtype, virus positivity, localization, therapy, and follow-up. RESULTS: A total of 163 cases were evaluated. We found that hematopoietic stem cell transplantation was associated with early-onset T-PTLD, whereas late onset occurred after immunosuppression with steroids and azathioprine without administration of calcineurin inhibitors. The major independent favorable prognostic factors were T-PTLD of the large granular lymphocytic leukemia subtype, young age, and a combination of radiotherapy/radiochemotherapy and reduced immunosuppression, whereas the hepatosplenic T-cell lymphoma subtype and cases with involvement of bone marrow, the central nervous system, or graft had an adverse prognosis. CONCLUSION: T-PTLD is a heterogeneous group of different aberrant T-cell proliferations and represents a significant complication following transplantation, showing a uniformly poor prognosis.&lt;/AbstractText&gt;
  1980. &lt;/Abstract&gt;
  1981. &lt;Affiliation&gt;1 Institute of Pathology, Hannover Medical School, Hannover, Germany. 2 Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany. 3 Department of Paediatric Haematology and Oncology, University Hospital Munich, Munich, Germany. 4 Address correspondence to: Kais Hussein, Dr. med., Institute of Pathology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.&lt;/Affiliation&gt;
  1982. &lt;AuthorList&gt;
  1983. &lt;Author&gt;
  1984. &lt;LastName&gt;Tiede&lt;/LastName&gt;
  1985. &lt;ForeName&gt;Christina&lt;/ForeName&gt;
  1986. &lt;Initials&gt;C&lt;/Initials&gt;
  1987. &lt;/Author&gt;
  1988. &lt;Author&gt;
  1989. &lt;LastName&gt;Maecker-Kolhoff&lt;/LastName&gt;
  1990. &lt;ForeName&gt;Britta&lt;/ForeName&gt;
  1991. &lt;Initials&gt;B&lt;/Initials&gt;
  1992. &lt;/Author&gt;
  1993. &lt;Author&gt;
  1994. &lt;LastName&gt;Klein&lt;/LastName&gt;
  1995. &lt;ForeName&gt;Christoph&lt;/ForeName&gt;
  1996. &lt;Initials&gt;C&lt;/Initials&gt;
  1997. &lt;/Author&gt;
  1998. &lt;Author&gt;
  1999. &lt;LastName&gt;Kreipe&lt;/LastName&gt;
  2000. &lt;ForeName&gt;Hans&lt;/ForeName&gt;
  2001. &lt;Initials&gt;H&lt;/Initials&gt;
  2002. &lt;/Author&gt;
  2003. &lt;Author&gt;
  2004. &lt;LastName&gt;Hussein&lt;/LastName&gt;
  2005. &lt;ForeName&gt;Kais&lt;/ForeName&gt;
  2006. &lt;Initials&gt;K&lt;/Initials&gt;
  2007. &lt;/Author&gt;
  2008. &lt;/AuthorList&gt;
  2009. &lt;Language&gt;ENG&lt;/Language&gt;
  2010. &lt;PublicationTypeList&gt;
  2011. &lt;PublicationType&gt;JOURNAL ARTICLE&lt;/PublicationType&gt;
  2012. &lt;/PublicationTypeList&gt;
  2013. &lt;ArticleDate DateType="Electronic"&gt;
  2014. &lt;Year&gt;2013&lt;/Year&gt;
  2015. &lt;Month&gt;1&lt;/Month&gt;
  2016. &lt;Day&gt;4&lt;/Day&gt;
  2017. &lt;/ArticleDate&gt;
  2018. &lt;/Article&gt;
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  2020. &lt;MedlineTA&gt;Transplantation&lt;/MedlineTA&gt;
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  2028. &lt;Year&gt;2013&lt;/Year&gt;
  2029. &lt;Month&gt;1&lt;/Month&gt;
  2030. &lt;Day&gt;9&lt;/Day&gt;
  2031. &lt;Hour&gt;6&lt;/Hour&gt;
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  2051. &lt;ArticleId IdType="doi"&gt;10.1097/TP.0b013e3182762e07&lt;/ArticleId&gt;
  2052. &lt;ArticleId IdType="pubmed"&gt;23296147&lt;/ArticleId&gt;
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  2056.  
  2057.  
  2058. &lt;PubmedArticle&gt;
  2059. &lt;MedlineCitation Status="Publisher" Owner="NLM"&gt;
  2060. &lt;PMID Version="1"&gt;23295192&lt;/PMID&gt;
  2061. &lt;DateCreated&gt;
  2062. &lt;Year&gt;2013&lt;/Year&gt;
  2063. &lt;Month&gt;1&lt;/Month&gt;
  2064. &lt;Day&gt;8&lt;/Day&gt;
  2065. &lt;/DateCreated&gt;
  2066. &lt;Article PubModel="Print-Electronic"&gt;
  2067. &lt;Journal&gt;
  2068. &lt;ISSN IssnType="Print"&gt;0392-856X&lt;/ISSN&gt;
  2069. &lt;JournalIssue CitedMedium="Print"&gt;
  2070. &lt;PubDate&gt;
  2071. &lt;Year&gt;2012&lt;/Year&gt;
  2072. &lt;Month&gt;Dec&lt;/Month&gt;
  2073. &lt;Day&gt;6&lt;/Day&gt;
  2074. &lt;/PubDate&gt;
  2075. &lt;/JournalIssue&gt;
  2076. &lt;Title&gt;Clinical and experimental rheumatology&lt;/Title&gt;
  2077. &lt;ISOAbbreviation&gt;Clin. Exp. Rheumatol.&lt;/ISOAbbreviation&gt;
  2078. &lt;/Journal&gt;
  2079. &lt;ArticleTitle&gt;Relevant incidence of cervical arthritis in patients with erosive seropositive rheumatoid arthritis even today.&lt;/ArticleTitle&gt;
  2080. &lt;Pagination&gt;
  2081. &lt;MedlinePgn/&gt;
  2082. &lt;/Pagination&gt;
  2083. &lt;Abstract&gt;
  2084. &lt;AbstractText&gt;OBJECTIVES: This paper aims to investigate adherence to, and outcome of, radiographic screening of patients with rheumatoid arthritis (RA) for cervical involvement, given the availability of state of the art disease-modifying anti-rheumatic drug (DMARD) and biological therapies. METHODS: Cervical screening results and clinical information were obtained from the charts of 395 consecutive patients with rheumatoid arthritis who attended an academic rheumatology outpatient clinic in a 3-month interval. This sample was combined with eight patients who underwent C1-C2 fusion at the Department of Orthopaedic Surgery. RESULTS: Reports on cervical spine x-ray films were not found in the charts of 67 patients (17 %), including 21 (8 %) of the 257 patients with a disease duration of ≥5 years. Nevertheless, 17 (7%) of these 257 patients had an increased atlantodental distance. An additional 4 RA patients of the Department of Orthopaedics were added for a total of 21 patients with cervical arthritis, 13 of whom had no cervical symptoms. All 21 patients with cervical arthritis had erosive peripheral arthritis with at least 10 years of disease duration, and were positive for rheumatoid factor. Almost half of these patients were not under adequate DMARD therapy when cervical instability was diagnosed, and none were on biological response modifiers. CONCLUSIONS: Screening for cervical arthritis is still of importance, especially in patients with erosive seropositive disease. In view of the documented incidence, adherence to screening protocols was disappointing.&lt;/AbstractText&gt;
  2085. &lt;/Abstract&gt;
  2086. &lt;Affiliation&gt;Division of Rheumatology, Department of Medicine III, University Clinical Centre Carl Gustav Carus at the Technical University of Dresden, Germany. ariane.hagenow@googlemail.com.&lt;/Affiliation&gt;
  2087. &lt;AuthorList&gt;
  2088. &lt;Author&gt;
  2089. &lt;LastName&gt;Hagenow&lt;/LastName&gt;
  2090. &lt;ForeName&gt;Ariane&lt;/ForeName&gt;
  2091. &lt;Initials&gt;A&lt;/Initials&gt;
  2092. &lt;/Author&gt;
  2093. &lt;Author&gt;
  2094. &lt;LastName&gt;Seifert&lt;/LastName&gt;
  2095. &lt;ForeName&gt;Jens&lt;/ForeName&gt;
  2096. &lt;Initials&gt;J&lt;/Initials&gt;
  2097. &lt;/Author&gt;
  2098. &lt;Author&gt;
  2099. &lt;LastName&gt;Zeissig&lt;/LastName&gt;
  2100. &lt;ForeName&gt;Astrid&lt;/ForeName&gt;
  2101. &lt;Initials&gt;A&lt;/Initials&gt;
  2102. &lt;/Author&gt;
  2103. &lt;Author&gt;
  2104. &lt;LastName&gt;Conrad&lt;/LastName&gt;
  2105. &lt;ForeName&gt;Karsten&lt;/ForeName&gt;
  2106. &lt;Initials&gt;K&lt;/Initials&gt;
  2107. &lt;/Author&gt;
  2108. &lt;Author&gt;
  2109. &lt;LastName&gt;Kleymann&lt;/LastName&gt;
  2110. &lt;ForeName&gt;Alexander&lt;/ForeName&gt;
  2111. &lt;Initials&gt;A&lt;/Initials&gt;
  2112. &lt;/Author&gt;
  2113. &lt;Author&gt;
  2114. &lt;LastName&gt;Aringer&lt;/LastName&gt;
  2115. &lt;ForeName&gt;Martin&lt;/ForeName&gt;
  2116. &lt;Initials&gt;M&lt;/Initials&gt;
  2117. &lt;/Author&gt;
  2118. &lt;/AuthorList&gt;
  2119. &lt;Language&gt;ENG&lt;/Language&gt;
  2120. &lt;PublicationTypeList&gt;
  2121. &lt;PublicationType&gt;JOURNAL ARTICLE&lt;/PublicationType&gt;
  2122. &lt;/PublicationTypeList&gt;
  2123. &lt;ArticleDate DateType="Electronic"&gt;
  2124. &lt;Year&gt;2012&lt;/Year&gt;
  2125. &lt;Month&gt;12&lt;/Month&gt;
  2126. &lt;Day&gt;6&lt;/Day&gt;
  2127. &lt;/ArticleDate&gt;
  2128. &lt;/Article&gt;
  2129. &lt;MedlineJournalInfo&gt;
  2130. &lt;MedlineTA&gt;Clin Exp Rheumatol&lt;/MedlineTA&gt;
  2131. &lt;NlmUniqueID&gt;8308521&lt;/NlmUniqueID&gt;
  2132. &lt;ISSNLinking&gt;0392-856X&lt;/ISSNLinking&gt;
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  2134. &lt;/MedlineCitation&gt;
  2135. &lt;PubmedData&gt;
  2136. &lt;History&gt;
  2137. &lt;PubMedPubDate PubStatus="received"&gt;
  2138. &lt;Year&gt;2012&lt;/Year&gt;
  2139. &lt;Month&gt;3&lt;/Month&gt;
  2140. &lt;Day&gt;27&lt;/Day&gt;
  2141. &lt;/PubMedPubDate&gt;
  2142. &lt;PubMedPubDate PubStatus="accepted"&gt;
  2143. &lt;Year&gt;2012&lt;/Year&gt;
  2144. &lt;Month&gt;6&lt;/Month&gt;
  2145. &lt;Day&gt;19&lt;/Day&gt;
  2146. &lt;/PubMedPubDate&gt;
  2147. &lt;PubMedPubDate PubStatus="entrez"&gt;
  2148. &lt;Year&gt;2013&lt;/Year&gt;
  2149. &lt;Month&gt;1&lt;/Month&gt;
  2150. &lt;Day&gt;9&lt;/Day&gt;
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  2162. &lt;Year&gt;2013&lt;/Year&gt;
  2163. &lt;Month&gt;1&lt;/Month&gt;
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  2171. &lt;ArticleId IdType="pii"&gt;5996&lt;/ArticleId&gt;
  2172. &lt;ArticleId IdType="pubmed"&gt;23295192&lt;/ArticleId&gt;
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  2175. &lt;/PubmedArticle&gt;
  2176.  
  2177.  
  2178. &lt;PubmedArticle&gt;
  2179. &lt;MedlineCitation Owner="NLM" Status="In-Data-Review"&gt;
  2180. &lt;PMID Version="1"&gt;23294055&lt;/PMID&gt;
  2181. &lt;DateCreated&gt;
  2182. &lt;Year&gt;2013&lt;/Year&gt;
  2183. &lt;Month&gt;01&lt;/Month&gt;
  2184. &lt;Day&gt;08&lt;/Day&gt;
  2185. &lt;/DateCreated&gt;
  2186. &lt;Article PubModel="Print"&gt;
  2187. &lt;Journal&gt;
  2188. &lt;ISSN IssnType="Electronic"&gt;1399-6576&lt;/ISSN&gt;
  2189. &lt;JournalIssue CitedMedium="Internet"&gt;
  2190. &lt;Volume&gt;57&lt;/Volume&gt;
  2191. &lt;Issue&gt;2&lt;/Issue&gt;
  2192. &lt;PubDate&gt;
  2193. &lt;Year&gt;2013&lt;/Year&gt;
  2194. &lt;Month&gt;Feb&lt;/Month&gt;
  2195. &lt;/PubDate&gt;
  2196. &lt;/JournalIssue&gt;
  2197. &lt;Title&gt;Acta anaesthesiologica Scandinavica&lt;/Title&gt;
  2198. &lt;ISOAbbreviation&gt;Acta Anaesthesiol Scand&lt;/ISOAbbreviation&gt;
  2199. &lt;/Journal&gt;
  2200. &lt;ArticleTitle&gt;Clinical impact of the publication of S3 guidelines for intensive care in cardiac surgery patients in Germany: results from a postal survey.&lt;/ArticleTitle&gt;
  2201. &lt;Pagination&gt;
  2202. &lt;MedlinePgn&gt;206-13&lt;/MedlinePgn&gt;
  2203. &lt;/Pagination&gt;
  2204. &lt;ELocationID EIdType="doi" ValidYN="Y"&gt;10.1111/aas.12009&lt;/ELocationID&gt;
  2205. &lt;Abstract&gt;
  2206. &lt;AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND"&gt;The development and implementation of practice guidelines might be an important tool to evaluate the different practices and to consider different local strategies.&lt;/AbstractText&gt;
  2207. &lt;AbstractText Label="METHODS" NlmCategory="METHODS"&gt;A postal questionnaire with 37 questions was sent to the leading physicians of 80 intensive care units in Germany, treating patients after cardiothoracic surgery. The survey covered the same core questions on current practice of hemodynamic monitoring, volume replacement, inotropic/vasopressor support, and transfusions before and after the publication of an S3 guideline.&lt;/AbstractText&gt;
  2208. &lt;AbstractText Label="RESULTS" NlmCategory="RESULTS"&gt;A total of 77.5 % of the completed questionnaires were returned. Monitoring changed to increased use of central venous oxygen saturation (S(cv) O(2) ) in 55.1% (2005: 20.9%), end-tidal CO(2) -monitoring 36.2% (2005: 24.3%), and decreased use of the left atrial pressure with 12.3% (2005: 23.3%) and pulmonary artery catheter 47.5% (2005: 58.2%). For volume therapy, there is a decreased use of Hydroxyethyl starch (HES) with 38.7% (2005: 63.4%) and an increased use of crystalloids 41.9% (2005: 22.4%). For inotropes, there is a trend to a decreased use of dopamine with 9.7% (2005: 29.1%, P = 0.074). The clinical relevance of the guidelines was judged 'high' by 43.5% and 'medium' by 50% of the responding physicians; however, change of treatments was reported by one quarter of respondents.&lt;/AbstractText&gt;
  2209. &lt;AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS"&gt;Despite ongoing variability in the use of monitoring devices, volume replacement and vasopressor/inotrope use in cardiac surgery patients, there have been some changes in the therapy of these patients after publication of the guidelines. Because the guideline has been considered as clinically relevant, further interdisciplinary development and implementation support should be considered.&lt;/AbstractText&gt;
  2210. &lt;CopyrightInformation&gt;© 2012 The Authors. Acta Anaesthesiologica Scandinavica © 2012 The Acta Anaesthesiologica Scandinavica Foundation.&lt;/CopyrightInformation&gt;
  2211. &lt;/Abstract&gt;
  2212. &lt;Affiliation&gt;Campus Virchow-Klinikum and Campus Charité Mitte, Department of Anaesthesiology and Intensive Care, Charité-University Medicine, Berlin, Germany.&lt;/Affiliation&gt;
  2213. &lt;AuthorList CompleteYN="Y"&gt;
  2214. &lt;Author ValidYN="Y"&gt;
  2215. &lt;LastName&gt;Kastrup&lt;/LastName&gt;
  2216. &lt;ForeName&gt;M&lt;/ForeName&gt;
  2217. &lt;Initials&gt;M&lt;/Initials&gt;
  2218. &lt;/Author&gt;
  2219. &lt;Author ValidYN="Y"&gt;
  2220. &lt;LastName&gt;Carl&lt;/LastName&gt;
  2221. &lt;ForeName&gt;M&lt;/ForeName&gt;
  2222. &lt;Initials&gt;M&lt;/Initials&gt;
  2223. &lt;/Author&gt;
  2224. &lt;Author ValidYN="Y"&gt;
  2225. &lt;LastName&gt;Spies&lt;/LastName&gt;
  2226. &lt;ForeName&gt;C&lt;/ForeName&gt;
  2227. &lt;Initials&gt;C&lt;/Initials&gt;
  2228. &lt;/Author&gt;
  2229. &lt;Author ValidYN="Y"&gt;
  2230. &lt;LastName&gt;Sander&lt;/LastName&gt;
  2231. &lt;ForeName&gt;M&lt;/ForeName&gt;
  2232. &lt;Initials&gt;M&lt;/Initials&gt;
  2233. &lt;/Author&gt;
  2234. &lt;Author ValidYN="Y"&gt;
  2235. &lt;LastName&gt;Markewitz&lt;/LastName&gt;
  2236. &lt;ForeName&gt;A&lt;/ForeName&gt;
  2237. &lt;Initials&gt;A&lt;/Initials&gt;
  2238. &lt;/Author&gt;
  2239. &lt;Author ValidYN="Y"&gt;
  2240. &lt;LastName&gt;Schirmer&lt;/LastName&gt;
  2241. &lt;ForeName&gt;U&lt;/ForeName&gt;
  2242. &lt;Initials&gt;U&lt;/Initials&gt;
  2243. &lt;/Author&gt;
  2244. &lt;/AuthorList&gt;
  2245. &lt;Language&gt;eng&lt;/Language&gt;
  2246. &lt;PublicationTypeList&gt;
  2247. &lt;PublicationType&gt;Journal Article&lt;/PublicationType&gt;
  2248. &lt;/PublicationTypeList&gt;
  2249. &lt;/Article&gt;
  2250. &lt;MedlineJournalInfo&gt;
  2251. &lt;Country&gt;England&lt;/Country&gt;
  2252. &lt;MedlineTA&gt;Acta Anaesthesiol Scand&lt;/MedlineTA&gt;
  2253. &lt;NlmUniqueID&gt;0370270&lt;/NlmUniqueID&gt;
  2254. &lt;ISSNLinking&gt;0001-5172&lt;/ISSNLinking&gt;
  2255. &lt;/MedlineJournalInfo&gt;
  2256. &lt;CitationSubset&gt;IM&lt;/CitationSubset&gt;
  2257. &lt;/MedlineCitation&gt;
  2258. &lt;PubmedData&gt;
  2259. &lt;History&gt;
  2260. &lt;PubMedPubDate PubStatus="accepted"&gt;
  2261. &lt;Year&gt;2012&lt;/Year&gt;
  2262. &lt;Month&gt;9&lt;/Month&gt;
  2263. &lt;Day&gt;18&lt;/Day&gt;
  2264. &lt;/PubMedPubDate&gt;
  2265. &lt;PubMedPubDate PubStatus="entrez"&gt;
  2266. &lt;Year&gt;2013&lt;/Year&gt;
  2267. &lt;Month&gt;1&lt;/Month&gt;
  2268. &lt;Day&gt;9&lt;/Day&gt;
  2269. &lt;Hour&gt;6&lt;/Hour&gt;
  2270. &lt;Minute&gt;0&lt;/Minute&gt;
  2271. &lt;/PubMedPubDate&gt;
  2272. &lt;PubMedPubDate PubStatus="pubmed"&gt;
  2273. &lt;Year&gt;2013&lt;/Year&gt;
  2274. &lt;Month&gt;1&lt;/Month&gt;
  2275. &lt;Day&gt;9&lt;/Day&gt;
  2276. &lt;Hour&gt;6&lt;/Hour&gt;
  2277. &lt;Minute&gt;0&lt;/Minute&gt;
  2278. &lt;/PubMedPubDate&gt;
  2279. &lt;PubMedPubDate PubStatus="medline"&gt;
  2280. &lt;Year&gt;2013&lt;/Year&gt;
  2281. &lt;Month&gt;1&lt;/Month&gt;
  2282. &lt;Day&gt;9&lt;/Day&gt;
  2283. &lt;Hour&gt;6&lt;/Hour&gt;
  2284. &lt;Minute&gt;0&lt;/Minute&gt;
  2285. &lt;/PubMedPubDate&gt;
  2286. &lt;/History&gt;
  2287. &lt;PublicationStatus&gt;ppublish&lt;/PublicationStatus&gt;
  2288. &lt;ArticleIdList&gt;
  2289. &lt;ArticleId IdType="doi"&gt;10.1111/aas.12009&lt;/ArticleId&gt;
  2290. &lt;ArticleId IdType="pubmed"&gt;23294055&lt;/ArticleId&gt;
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  2292. &lt;/PubmedData&gt;
  2293. &lt;/PubmedArticle&gt;
  2294.  
  2295. </pre>
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