from xlrd import open_workbook
import os.path
wb = open_workbook('C:UsersxxxxDesktopa.xlsx')

Error:Traceback (most recent call last):
File "C:Python271.py", line 3, in <module>
wb = open_workbook('C:UsersxxxxDesktopa.xlsx')
File "C:Python27libsite-packagesxlrd__init__.py", line 429, in open_workbook
biff_version = bk.getbof(XL_WORKBOOK_GLOBALS)
File "C:Python27libsite-packagesxlrd__init__.py", line 1545, in getbof
bof_error('Expected BOF record; found %r' % self.mem[savpos:savpos+8])
File "C:Python27libsite-packagesxlrd__init__.py", line 1539, in bof_error
raise XLRDError('Unsupported format, or corrupt file: ' + msg)
xlrd.biffh.XLRDError: Unsupported format, or corrupt file: Expected BOF record; found     'PKx03x04x14x00x06x00'