class User(models.Model):
    uuid = models.UUIDField(default=uuid.uuid4, primary_key=True, editable=False, db_index=True)
    email = models.EmailField(_('email address'), blank=False, unique=True, db_index=True)

class Match(models.Model):
    uuid = models.UUIDField(default=uuid.uuid4, editable=False, primary_key=True)
    users = models.ManyToManyField(User, related_name='matches')

query = reduce(operator.or_, (Q(users__user__uuid=item) for item in LIST))
result = Match.objects.filter(query)

test = Match.objects.filter(users__user__in=LIST))

test = Match.objects.filter(users__in=LIST)

def list_uuid(user1, user2):
    return {str(user.uuid), str(user2.uuid)}

qs = Match.objects.filter(uuid__in=user1.matches.all(), users=user2).count()