from netaddr import IPAddress, IPNetwork

with open("your file.txt", "r") as f:
    for line in f:
        if "/" in line:
            ip_network = IPNetwork(line)
            print "{},{}".format(
                ip_network.first,
                ip_network.last
            )
        if "," in line:
            first_ip, last_ip = line.split(",")
        else:
            first_ip = last_ip = line
        print "{},{}".format(
            int(IPAddress(first_ip)),
            int(IPAddress(last_ip))
        )