Unlocking The Lost

In order to unlock The Lost, you must kill yourself in very specific ways in a very specific order.

First you must die to a Mulliboom as Isaac in one of the Basement floors.
Second you must die to a bomb blast as Magdalene in one of the Caves floors.
Third you must die to Mom's Foot as Judas in one of the Depths floors.
Last you must die to the second stage of Satan as Azazel in Sheol.

You cannot die in other ways between these specific death runs, you cannot reset between runs, and you cannot use seeds.

The Lost starts with flying, and has no health, nor can he gain health through normal health pick ups. However, he can take devil deals for free.