SMIs
Only sm is abundant enough to generate ceramide rapidly.
ent-12 (one acyl chain replaced by benzyl, difluoride) ic50 3.3 uM while SM ic50 60 uM.
L-carnitine (looks like PC) moderately inhibiting.
AD2765 (one acyl chain replaced by thiourea butyl) ki 50 uM.
Protonated FIASMs stimulate proteolytic degradation of ASM by shielding BMP and detaching asm from membrane. No effect in vitro.
N-3,5-bPs and PI-3,5-bP moderately inhibit ASM. Single acyl chain analogues work as well.
ARC 39 (geminal biphosphonate with single acyl chain) ic50 20 nM.