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Prepare for errors and disorganization. You have been warned.

Special Note: Get a lot of perks in science mastery (Star Trek, DC, Venture Bros, James Bond, etc) and genetic manipulation (Resident Evil, Geneforge, Deadman Wonderland, etc).

Defense-
For this to work best, to things are needed. Note: Either can be replaced or supplemented with enough science and magic mastery, but they form the best base grounds for what is desired.
One:
Savage Salvage=Kantai Colletion: Anything you devour your body absorb and replicate if biologically possible.
Two:
Techno-organic=Transformers: Being both flesh and metal, and neither at the same time.
With this, anything one eats (except maybe magical items) is now biologically possible for one to use.

For a bonus, get something like "craftsman of the gods" from Viking saga to increase the power/abilities of these items.
Ingredients:
Proto Adamantium=Marvel: The combination of both Adamantium (a very dense, artificial, iron-based alloy that is virtually indestructible. A sufficient amount is capable of surviving multiple nuclear explosions with no damage) and Vibranium (possesses the ability to absorb all vibrations in the vicinity and directed at it. The energy absorbed is stored within the bonds between the molecules that make up the substance. As a result, the more energy Vibranium absorbs the tougher it becomes.).
Bio-steel=Starcraft: Grants metal the ability to regenerate and repair itself like a living organism.
Environmental Nanites=Megaman X: Capable of withstanding the heat of magma.
Koopa Shell=Mario RPB: A Turtle shell that is immune to the heat of lava.
WHOOP Brute Suit=Totally Spies Martin Mystery: A combat suit that can withstand the force (not heat) of 100,000 megatrons.
Mandalorian iron/Beskar=KotOR: Notable for being able to withstand blows from even a lightsaber, and was commonly thought to be nearly indestructible.
Phrik=Kotor: A rare metallic (phrikite mines of Gromas 16 which would be combined with tydirium) compound that is extremely durable and light. It is resistant to lightsaber attacks and is able to disperse electricity. A container of phrik was able to stay intact when it was on the surface of Alderaan during its destruction. While in its smelting stage, it is highly malleable, and can be combined with a number of other ores, alloys, and compounds to imbue the phrik's properties with others.
Mithril=LotR: "All folk desired it. It could be beaten like copper, and polished like glass; and the Dwarves could make of it a metal, light and yet harder than tempered steel. Its beauty was like to that of common silver, but the beauty of mithril did not tarnish or grow dim."
Neutronium=Star Trek: A dense mineral that is invulnerable to phaser fire and photon torpedoes.
Nth Metal=DC:Has The ability to negate gravity, protects the wearer from the elements, speeds the healing of wounds, increases their strength, protects against extreme temperature, and negates dimensional shifting such as ghosts.
Promethium=DC: The metal had regenerative properties which could be used in metallic creations that could mend themselves, or be used to make highly destructive weapons. Two other versions of Promethium exist. "Depleted" and "Volatile"
Depleted; When alloyed with titanium and vanadium, it forms a near-invulnerable metal.
Volatile; Capable of generating and absorbing near-limitless amounts of energy, and so can be used as a power source for many gadgets.
Uru=Marvel:Resilient to most forms of damge, especially when enchanted. Easy to enchant, but also absorbs magic like a sponge, redirecting it and enhancing the natural attributes of his wielder. (Magic version of Vibranium)
Adamantium Beta=Slightly weaker version of Adamantium the can heal itself thanks to being bonded/forged to Wolverine's skeleton.
Apex Metal=Transformers: Reversed engineered from the Apex Armor, an armor that is considered indestructible by Cybertronians.
Gold Digizoid=Digimon: An alloy of Chrome Digizoid that shines with a divine, golden radiance, and renders the user completely invulnerable. It also allows the user to attain high defensive and offensive power without losing speed.

Splicing: Genes to be acquired through a combination of genetic mastery, prototype powers, and savage salvage. Capturing/acquiring genetics will should be easy for any build with high stealth and teleportation alone.
KotOR/Star Wars-
Felucian Skullblade: Constructed from the skull and teeth of specific Felucia native creatures. These creatures grew trace amounts of Force-reactive crystals, similar to those used in the construction of lightsabers, in their bones allowing weapons constructed from them, when imbued with the Force, to block lightsabers and blaster fire.
Ysalamir: Creatures from the planet Myrkr. They are able to produce a Force-neutral bubble that repels the force.
Gen'Dai: A boneless species made of virtually a formless jumble of corded muscle and nerve bundles. Lacking the vulnerable vital organs of most species, including hearts, and lungs, they can take extreme injuries and even complete dismemberment, and survive which gave them the reputation of being immortal. They can regrow lost limbs or other body parts in only a few minutes. They posses a nervous system which was distributed throughout the body in the form of millions of nerve clusters. Giving the species near instantaneous reflexes as well as the ability to sustain a high volume of injuries without any overall damage. So high was their sensory acuity, that the Gen'Dai were able to feel a Human's heartbeat from ranges of up to 200 meters.
Star Trek:
Khan Noonien Singh: A super human with Captain America level abilities. Immune to the stun setting on phasers. Cells regenerate at a high enough as to be relatively immune to radiation poisoning.
DC-
Doomsday:
Reactive Adaptation/Healing Factor – Doomsday develops and adapts an immunity to any attack that harms him. This has been show to also weaponize doomsday, to allow him to attack other opponents. Good examples of this are when he breathed flames against the Martian Manhunter;elongated his knuckle protrusions to attack Superman in the air; or canceled out Radiant, a being of pure energy, by generating an aura of energy and slamming it into Radiant.
“Invulnerability” - Doomsday possesses a very high durability capacity, which can only be penetrated by other strong forces, certain radiation exposure can harm him. Military weaponry like bombs, missiles, grenades, rockets, laser beams, even the force of a nuclear explosion cannot harm Doomsday. Doomsday is said to be as durable (if not more so) as Superman, who can withstand 10 octillion MT.
Super strength - Doomsday's muscular density is extremely high. Doomsday's physical output and strength astronomically exceeds that of humans and is significantly stronger than Kryptonians (AKA superman). The exact magnitude and exertion that he is capable of remains undefined and unclear. In listing he can most likely pick up multiple-mega-tons. However, Doomsday has been said to be even stronger than a normal level Superman, who can lift several quintillion tons.
Superhuman Speed - He is capable of moving, reacting, and possible even running at the same speed as Superman. Superman being, while not as fast as the Flash, considered one of the fastest beings in the universe. Once recorded at around 5 billion mph (Speed of light is 670,616,629 mph). Though Doomsday is most likely slower than Superman, he once managed to render most of the Justice League incapable of fighting in a matter of moments.
Enhanced Stamina – Doomsday has demonstrated seemingly inexhaustible amounts of stamina. He demonstrated the ability to fight Superman for an entire day without tiring. However, his stamina is far from unlimited.
Self-Sustenance - He can survive in space and can even operate while in the direct presence of space vacuums, vortexes and wormholes, and he doesn't require oxygen, water, or any form of nourishment to maintain himself.

Damage reducers:
Armored Shell 2=Bioshock: 40k% Damage reduction to piercing and kinetic attacks.
Scales of Steel=Dragon Commander: Any damage taken is reduced by 35%.

Vitality: Rapid Recovery/Repair.
Regen=Infamous: Can heal from most non-lethal wounds in seconds.
Self Repair=Mega Man X: Nanites within the body repair self and nearby allies at a slowish pace outside of combat.
Infection Immune=Dead Rising: Moderate regeneration capacity to heal from flesh wounds in hours.
Blacklight Prototype Infection=Prototype: Provides significant cellular regeneration and control due to activating all unused DNA. Capable of rebuilding entire limbs if given sufficient biomass.
Regeneration=DMC:Repair non-fatal wounds within seconds. Regrow limbs in a few hours.
Regeneration=Invader Zim: Lost organs and shattered bones will repair themselves within minutes.
Rejuvenation=Dragon Commander: Health regenerates slightly quicker.
Warrior=Smite: Incredible natural regeneration.
Greater Regeneration=Madoka: Heal faster
Healing Factor=Marvel: Regrow limbs and organs withing hours.
Rolling Counter=Mother:Any damage taken, even if fatal, you will have a few seconds before it takes full effect

Immunity: Immunity to plague, disease, and poison.
Steel Type [gene splice]=Pokemon: Steel Types are immune to poison.
Normal Type [gene splice]=Pokemon: Normal Types are immune to ghosts.
Ghost Type {Golurk}=PMD:Immune to fighting and normal in pokemon. High resistance vs physical attacks elsewhere.
Android=Lego: Immune to hostile biological agents.
FEV=Fallout: A shifting-absorptive mega-virus with a protein sheath reinforced by ionized hydrogen that makes it immune to irradiation. It also provides cellular repair with no decay. FEV also eliminates all unused DNA strands, providing immunity to disease.
Infection Immune=Dead Rising: Provides immunity to homo-Coprophagous-Somnambulus parasite/viruses. As well as possessing a general resistance to disease and parasites.
Immune=Horror Movie: Immunity to even the most virulent and dangerous diseases.
Immune=Prototype:Immune to almost every pathogen including Redlight virus.
Hostile Effects Resistance=Geneforge: 25% resistance to poison.
Spliced=CATastrophe: More resistant to disease.
Poison Immunity=Elder Scrolls: Fire does half damage. Complete immunity to all poisons.
Might=LotR: Unlikely to get sick.

Endurance: Infinite Stamina.
Endurance Level 4=Body: Run all day without tiring. Won't feel sore in the morning.
Android=Lego: No need to eat, sleep, or breathe.
Stamina-Outstanding=Vampire the Requiem: Constitution is truly herculean (virtually limitless)
Rabbit's Foot=CATastrophe: Greatly increased endurance.
Might=LotR: Walk or run for hours on end without tiring.

Dispel:Immunity to any and all magic, especially harmful.
Protection=FFT: High resistance to magical attacks.
Twilight Imperium=Mahou Sensei: Incredibly resilient to magic to the point that every from of magic has no effect unless allowed.
True to Your Nature=DRESDEN: Extreme resistance to nearly all combat magic.
Cold Resistant=Elder Scrolls: Frost magic does half damage.
Heat Resistant=Elder Scrolls: Flame magic does half damage.
Dragon Skin=Elder Scrolls: Ignores 25% of magical damage by absorbing it.
Magic Resistance=Ravenloft: Normal-level spells and supernatural fail to have effect.
Templar=Dragon Age: Ability to dispel and resist magic.

Mental Defense:Focus on mental defense to protect against psychic powers (and possibly fear).
Dark Type [gene splice]=Pokemon: Dark Types are immune to psychics.
Conversion Resistance=KND:Virtual Immunity to forced mental, magical, etc alterations.
True to Your Nature=DRESDEN: Increased mental fortitude.
Hostile Effects Resistance=Geneforge: 25% resistance to mental effects. Resistance to stunned.
Occlumency=Harry Potter: Makes it difficult to posses are penetrate the mind. No tells, and impossible to know if lying without evidence.
Mental Fortitude=LotR: Hardy soul and a powerful will. Even the darkest of mind magics take far longer to take grip.
Iron Will=Ravenloft: Immune to all but the strongest mind effecting magic and abilities. Even then they have a greatly reduced effect.
Mind Shield=Xcom: An implant that greatly hardens mental defenses against psychic attack and can guard against low-level psychic manipulation.
Abberrant=Star Wars Clone Wars: Immunity to psionics.
Neural Feedback=Xcom: Causes damage to psi attackers.
Mental Resistance=DC: Pheromones and magical mind control doesn't stick. Even capable of blocking out mind readers.
Solo Pilot=Pacific Rim: Massive boost to willpower.

Titanicus Elements:
Walking Inferno=Bioshock: Reduces all heat damage by 90%. Increases personal heat attacks.
Electrokinesis=Infamous: Living conduit for electricity.
Hostile Effects Resistance=Geneforge: 25% resistance to fire, cold, and acid.
Elemental Mastery Cold=Generic Fighting Game:Name. Bend and create at your will. Cannot be harmed by it.
Electromaster=Summon/Control of electricity and slight control of magnetism.

Misc:
Forerunner combat skin=Halo Gauntlet: Provides levitation and telekinesis.
Mimetic Skin=Xcom: Confers the ability to change skin pattern to match cover.

Bonus/Notable Powers:
Use "Savage Salvage" on
	Ecto-skeleton=Danny Phantom: A suit that increases all physical and spiritual abilities by 100x.
What Doesn't Kill Me=Genetic Virtual World: Can build up resistance and immunity countermeasures the more you face a certain type of damage/injury.
Soft-cap=Elona:There is no cap to your skills and physical attributes. Only limit is time.
Que Training montage sequence. With half of it having personal weapons and friends kicking the crap out of you.

(Typo: WHOOP Brute Suit is supposed to be megatons, not megatrons. Keeping the typo because it makes me giggle)