import pandas as pd
from xlrd import open_workbook

#contains mapping, Column present
#DataFileName   FolderLocation  ColumnFileName
#Data1           F:Desktop      ColFile1
#Data2           F:Desktop      ColFile2

filelocation = 'F:DesktopMapping.xlsx'
wb = open_workbook(filelocation)
Separator = ','
items = []
for sheet in wb.sheets():
    number_of_rows = sheet.nrows
    number_of_columns = sheet.ncols
    for row in range(1, number_of_rows):
        for col in range(number_of_columns):
            ColumnFileName = sheet.cell(row,0).value
            Path = sheet.cell(row,1).value
            DataFileName = sheet.cell(row,2).value

            DataFileCompName = Path + "\" + DataFileName +FileExtension
            ColumnFileCompName = Path + "\" + ColumnFileName+ FileExtension
            HeaderDataFrame = pd.read_csv(ColumnFileCompName,sep=Separator)#,index_col=0)#,header=0)
            DataDataFrame = pd.read_csv(DataFileCompName,sep=Separator)#,header=None)

            CompleteDataFrame = pd.concat([HeaderDataFrame,DataDataFrame], ignore_index=True,axis=1)

HeaderDataFrame
DataDataFrame

HeaderDataFrame|DataDataFrame