Femgen's HRT information 10/10/16

WARNING: This is illegal in the US and Europe unless the medical system is involved. It may also be cost-prohibitive. This article recommends purchasing chemicals at alldaychemist.com (ADC) and Indian grey-market pharmacy. You can also use inhousepharmacy.vu (IHP), qhi.co.uk (QHI), kiwidrug.com, and of course darknetmarkets and alibaba. Regardless of where you buy, expect at least 2 weeks shipping. If you live in a country where mail is searched, look to local suppliers, darknetmarkets, and ADC in that order.

N.B.: This guide does not recommend under any circumstance the excessive consumption of phytoestrogens or supplements. They do nothing. Altering your diet will change very little. Altering your biochemistry will change very much (except bone structure).

This pertains to post or mid-pubescent biological males. If you are past the age of 24 you will find it very difficult if not impossible to become androgynous. Most reach sufficient sexual dimorphism by the age of 16. The majority of truly androgynous icons (Andreja, Stav, etc) have been blocking testosterone from an early age. If your goal is to pass for female, >>>/lgbt/passgen/ and >>>/lgbt/hrtg/. To be physically androgynous, one can take Estrogen (E), Selective Estrogen Receptor Modulators (SERMs), or an Androgen Blockade (ADT).

Each involve an anti-androgen (AA). Androgen refers to testosterone, the male sex hormone. There are dozens of AAs. Most will make you permanently sterile after extended usage (2+ years). We focus on three:

Spironolactone (FDA-Branded Aldactone), the most common AA used in the US. Cheap, safe, weak. Average daily dose: 200mg. Typical range: 100-300mg. Bulk cost on ADC: $10/month
Cyproterone Acetate (FDA-Branded Androcur), the most common AA in Europe. Invasive, strong. Average daily dose: 50mg. Typical range: 25-100mg. Bulk cost on ADC: $45/month
Bicalutamide (FDA-Branded Calutide), an obscure AA which does not result in permanent infertility. Expensive, experimental, strong. Average daily dose: 50mg. Typical range: 25-75mg. Bulk cost on ADC: $50/month.

We are very interested in bicalutamide's ability to prevent sterility and masculinizing. It works only by blocking androgens from binding to the androgen receptor, not by stopping androgen production. It also induces nuclear translocation after binding. (http://www.jbc.org/content/277/29/26321.full) Therefore, the effect of DHT will be decreased despite its production being increased and DHT having a stronger binding affinity for the androgen receptor than bicalutamide. It has has loss of libido in few cases, indicating reduced, but not eliminated, blood-brain barrier penetration. (http://www.antialabs.com/reference/21018026.pdf) Due to the non-androgenic anabolic effects of testosterone, it does not induce muscle loss. (https://www.ncbi.nlm.nih.gov/pubmed/20950306)


Back to the three strategies: E, SERMs, ADT

Estrogen: Note that you will grow breasts (ymmv) and likely become sterile regardless of AA used.
On average, take 4mg of Estradiol (hemihydrate > valerate) (FDA-Branded Estrofem, Progynova) along with your AA. For results, see: http://i.imgur.com/UhB4Ybz.png


SERMs: Note that few people take these, but no complications have been locally reported. A SERM works in conjunction with an anti-androgen to mitigate the side effects (osteoporosis, breast growth, depression, etc.) by triggering certain estrogen receptors and blocking others. SERMs are often given to post-menopausal women to reduce the risk of breast cancer; they represent the majority of research subjects. Bodybuilders occasionally illegally purchase SERMs (and sometimes SARMs) to use in conjunction with certain steroids. The SERMs outlined below are all breast tissue antagonists; they prevent breast growth and reduce breast size over time (experimental half life of around 2-3 months).

The chemicals in order of desirability: Raloxifene (R) (FDA-Branded Evista) > Tamoxifen (T) >> Clomifene (C)
Average daily doses: R: 60mg, T: 20mg, C: 50mg. Ranges: unknown

Tamoxifen can induce cognitive dysfunction. (https://link.springer.com/article/10.1023%2FA%3A1006426132338)

Raloxifene can fix cognitive dysfunction caused by antipyschotics in the treatment of schizophrenia. (https://www.ncbi.nlm.nih.gov/pubmed/27193386) It can also act as an antidepressant. (https://www.ncbi.nlm.nih.gov/pubmed/20961269) (https://www.ncbi.nlm.nih.gov/pubmed/22061801) It has some effects upon the serotonin system, and can improve memory and attention in healthy patients. (https://www.ncbi.nlm.nih.gov/pubmed/15577134)


Androgen Blockade: Also known as Androgen Deprivation Therapy, commonly used to treat prostate cancer. This should only be done under the specific direction of an endocrinologist. It can induce such side effects as a bad lipid profile, osteoporosis, and hot flashes without a SERM or full estrogen being used. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213888/)

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