import xlwings as xl
import xlwings.constants

s = xl.Book('doc.xlsx').sheets[0]
RR2 = s.api.Cells.Find(What="*",
                       After=s.api.Cells(1, 1),
                       LookAt=xlwings.constants.LookAt.xlPart,
                       LookIn=xlwings.constants.FindLookIn.xlFormulas,
                       SearchOrder=xlwings.constants.SearchOrder.xlByRows,
                       SearchDirection=xlwings.constants.SearchDirection.xlPrevious,
                       MatchCase=False)

RR = s.api.Cells.Find(What="*",
                      After=s.api.Cells(1, 1),
                      LookAt=xlwings.constants.LookAt.xlPart,
                      LookIn=xlwings.constants.FindLookIn.xlFormulas,
                      SearchOrder=xlwings.constants.SearchOrder.xlByColumns,
                      SearchDirection=xlwings.constants.SearchDirection.xlPrevious,
                      MatchCase=False)

print((RR2.Row, RR.Column))
pass