/var/www/mysite
|-- mysite
|    +-- templates/
|    +-- static/
|    +--__init__.py
+-- uwsgi.ini

[uwsgi]
chdir = /var/www/mysite/
socket = /tmp/mysite.sock
module = mysite
callable = app
vacuum = True
uid = www-data
gid = www-data

server {
    listen 80 default_server;
    listen [::]:80 default_server;

    root /var/www/html;
    index index.html index.htm;
    server_name _;

    location / { try_files $uri @mysite; }
    location @mysite {
        include uwsgi_params;
        uwsgi_pass unix:///tmp/mysite.sock;
    }
}

[Unit]
Description=uWSGI Emperor
After=syslog.target

[Service]
ExecStart=/usr/bin/uwsgi --ini /etc/uwsgi/emperor.ini
# Requires systemd version 211 or newer
RuntimeDirectory=uwsgi
Restart=always
KillSignal=SIGQUIT
Type=notify
StandardError=syslog
NotifyAccess=all

[Install]
WantedBy=multi-user.target

[uwsgi]
emperor = /etc/uwsgi/vassals
uid = www-data
gid = www-data

2016/02/09 17:45:01 [error] 1708#0: *304 upstream prematurely closed connection while reading response header from upstream, client: 123.123.123.123, server: _, request: "GET / HTTP/1.1", upstream: "uwsgi://unix:///tmp/mysite.sock:", host: "mysite.domain"