MY_MACRO((x, y))

MY_MACRO(x)

#define CONCAT_( x, y ) x ## y
#define CONCAT( x, y ) CONCAT_( x, y )
#define IS_SINGLE_1(...) 0
#define IGNORE(...)
#define IS_SINGLE_2_0           0 IGNORE(
#define IS_SINGLE_2_IS_SINGLE_1 1 IGNORE(
#define IS_SINGLE( x ) CONCAT( IS_SINGLE_2_, IS_SINGLE_1 x ) )
IS_SINGLE((x, y)) // 0
IS_SINGLE(x)      // 1

#include <boost/preprocessor/cat.hpp>
#include <boost/preprocessor/seq/for_each.hpp>

#define SEQ (w)(x)(y)(z)

#define MACRO(r, data, elem) BOOST_PP_CAT(elem, data)

BOOST_PP_SEQ_FOR_EACH(MACRO, _, SEQ) // expands to w_ x_ y_ z_

MACRO(1, a)
MACRO(2, (a,b) )
MACRO(3, (a,b,c) )