class MyEvents:

    def __init__(self):
        print("Callback class initialized")

    def OnMyEvent(self, data):
        print('MyEvent raised')

class ComUser:
    comObj = None

    def __init__(self):
        comObj = win32com.client.DispatchWithEvents("ProproetaryInterface.InterfaceClass",
                                          MyEvents)
        comObj.Register()
        comObj.DoSomething(data)
        time.sleep(120)


userObj = ComUser()

def __startPollingThread(self):
        pythoncom.CoInitialize()
        pollingThread = Thread(target=self.__checkQueue )
        pollingThread.start()
        pythoncom.CoUninitialize()

def __checkQueue(self):

        try:

            pythoncom.CoInitialize()
            while True:
                currMessage = self.__messageQueue.get()
                self.__processMessage(currMessage);
        except :
            #Log message
        finally:
            pythoncom.CoUninitialize()

def initSystem(self):
        import pythoncom
        try:
            pythoncom.CoInitialize()
            self.ComConnector = win32com.client.DispatchWithEvents("ProprietaryInterface.InterfaceClass",
                                              MyEvents)
            self.ComConnector.Register()

        except:
        finally:
            pythoncom.CoUninitialize()

def handleMessage(self, message):
    #if message = this then
    comObj.DoSomething(data)