#pip install pynput

import time
from pynput import keyboard

# The key combination to check
COMBINATIONS = [
    {keyboard.KeyCode(char='s')},
    {keyboard.Key.shift, keyboard.KeyCode(char='A')}
]

# The currently active modifiers
current = set()


def execute():
    print ("Do Something")
    time.sleep(5)
    
    
def on_press(key):
    if any([key in COMBO for COMBO in COMBINATIONS]):
        current.add(key)
        if any(all(k in current for k in COMBO) for COMBO in COMBINATIONS):
            execute()

def on_release(key):
    if any([key in COMBO for COMBO in COMBINATIONS]):
        current.remove(key)

with keyboard.Listener(on_press=on_press, on_release=on_release) as listener:
    listener.join()