import arcpy

Layer1 = arcpy.GetParameterAsText(0)
Tabela1 = arcpy.GetParameterAsText(1)
Estado = arcpy.GetParameterAsText(2).split(';')
Ano = arcpy.GetParameterAsText(3).split(';')
mxd = arcpy.mapping.MapDocument("CURRENT")
Saida = arcpy.GetParameterAsText(4)
stats = []

for lyr in arcpy.mapping.ListLayers(mxd):
    lyr.name = Layer1
    lyr.definitionQuery = """UF IN ({})""".format(Estado)

for field in arcpy.ListFields(Tabela1):
    if field.name in (Ano):
        stats.append([field.name, "SUM"])

arcpy.Statistics_analysis(Layer1, Saida, stats, "")
arcpy.RefreshActiveView()
arcpy.RefreshTOC()

Traceback (most recent call last):
  File "F:AgroBD.gdbM6a.py", line 19, in <module>
    arcpy.Statistics_analysis(Layer1, Saida, stats, "")
 File "c:program files (x86)arcgisdesktop10.3arcpyarcpyanalysis.py",
line 1160, in Statistics
    raise e
ExecuteError: ERROR 999999: Error executing function.
An invalid SQL statement was used.
An invalid SQL statement was used. [Brasil_Municipios]
An invalid SQL statement was used. [SELECT * FROM Brasil_Municipios WHERE UF
IN ([u'AC', u'AM'])]
An invalid SQL statement was used.
An invalid SQL statement was used. [Brasil_Municipios]
An invalid SQL statement was used. [SELECT OBJECTID FROM Brasil_Municipios
WHERE UF IN ([u'AC', u'AM'])]
The table was not found. [out3]
Failed to execute (Statistics).

Failed to execute (Script1).