Hypergranulotic dyscornification is a recently described pattern of epidermal dysmaturation.  It joins the other five epithelial reaction patterns: epidermal hyperkeratosis, focal acantholytic dyskeratosis, cornoid lamellation, pale-cell acanthosis and follicular mucinosis.[1]  Each of these five patterns is recognized in three clinical settings: as findings diagnostic for specific diseases, as benign solitary keratoses and as incidental findings in other conditions.[2] Unlike the other patterns, hypergranulotic dyscornification has to date only been described in solitary keratoses.  This paper describes ___ cases of hypergranulotic dyscornification, one case in which it is an incidental finding in conjunction with…. We postulate that hypergranulotic dyscornification will also one day be found as a diagnostic finding in a specific disease.

MATERIALS AND METHODS

HISTOPATHOLOGIC FINDINGS
 The histopathologic findings of the ___ cases are similar to those previously described. [3] Digitated or papillated epidermal hyperplasia with hypergranulosis and large keratohyaline granules.  The cornified layer shows laminated to compact orthokeratosis, which may be slightly basophilic. Eosinophilic globules in mounds are found in foci at the tips of the epidermal digitations. These rounded globules are thought to be the mummified ghosts of keratinocytes.[3]    Focal parakeratosis is present in foci over the abnormal cornification.
One yet undescribed finding is that of eosinophilic inclusions seen around nuclei in the upper epidermis.