$ istioctl create -f destination-rule.yaml

$  kubectl get po,deployments,svc,ing
NAME                           READY     STATUS    RESTARTS   AGE
po/be-v1-16151855-r8hn1        2/2       Running   0          29s
po/be-v2-4191276971-6j9q3      2/2       Running   0          28s
po/myapp-v1-2518991625-h521p   2/2       Running   0          29s
NAME              DESIRED   CURRENT   UP-TO-DATE   AVAILABLE   AGE
deploy/be-v1      1         1         1            1           29s
deploy/be-v2      1         1         1            1           29s
deploy/myapp-v1   1         1         1            1           29s
deploy/myapp-v2   0         0         0            0           29s