WPF Client App:

public partial class App : Application
    {
        public static IBus Bus { get; set; }
        protected override void OnStartup(StartupEventArgs e)
        {
            base.OnStartup(e);
            Bus = Configure.With()
                .Log4Net()
                .XmlSerializer()
                .MsmqTransport()
                    .IsTransactional(true)
                .UnicastBus()
                    .LoadMessageHandlers()
                .CreateBus()
                .Start();


            Bus.Send(new OneMessage() {Title = "This is a sample message"});
        }

    }

results in:

System.NullReferenceException was unhandled
  Message=Object reference not set to an instance of an object.
  Source=NServiceBus.Core
  StackTrace:
       at NServiceBus.ConfigureXmlSerializer.XmlSerializer(Configure config) in d:\BuildAgent-03\work\d692fe98ef9a76ca\src\impl\Serializers\NServiceBus.Serializers.XML.Config\ConfigureXmlSerializer.cs:line 20
       at Life.Store.Client.App.OnStartup(StartupEventArgs e) in C:\Users\daniel\Documents\open-source\Life.Store\src\Life.Store.Client\App.xaml.cs:line 21
       at System.Windows.Application.<.ctor>b__1(Object unused)
       at System.Windows.Threading.ExceptionWrapper.InternalRealCall(Delegate callback, Object args, Int32 numArgs)
       at MS.Internal.Threading.ExceptionFilterHelper.TryCatchWhen(Object source, Delegate method, Object args, Int32 numArgs, Delegate catchHandler)
       at System.Windows.Threading.DispatcherOperation.InvokeImpl()
       at System.Windows.Threading.DispatcherOperation.InvokeInSecurityContext(Object state)
       at System.Threading.ExecutionContext.runTryCode(Object userData)
       at System.Runtime.CompilerServices.RuntimeHelpers.ExecuteCodeWithGuaranteedCleanup(TryCode code, CleanupCode backoutCode, Object userData)
       at System.Threading.ExecutionContext.RunInternal(ExecutionContext executionContext, ContextCallback callback, Object state)
       at System.Threading.ExecutionContext.Run(ExecutionContext executionContext, ContextCallback callback, Object state, Boolean ignoreSyncCtx)
       at System.Threading.ExecutionContext.Run(ExecutionContext executionContext, ContextCallback callback, Object state)
       at System.Windows.Threading.DispatcherOperation.Invoke()
       at System.Windows.Threading.Dispatcher.ProcessQueue()
       at System.Windows.Threading.Dispatcher.WndProcHook(IntPtr hwnd, Int32 msg, IntPtr wParam, IntPtr lParam, Boolean& handled)
       at MS.Win32.HwndWrapper.WndProc(IntPtr hwnd, Int32 msg, IntPtr wParam, IntPtr lParam, Boolean& handled)
       at MS.Win32.HwndSubclass.DispatcherCallbackOperation(Object o)
       at System.Windows.Threading.ExceptionWrapper.InternalRealCall(Delegate callback, Object args, Int32 numArgs)
       at MS.Internal.Threading.ExceptionFilterHelper.TryCatchWhen(Object source, Delegate method, Object args, Int32 numArgs, Delegate catchHandler)
       at System.Windows.Threading.Dispatcher.InvokeImpl(DispatcherPriority priority, TimeSpan timeout, Delegate method, Object args, Int32 numArgs)
       at MS.Win32.HwndSubclass.SubclassWndProc(IntPtr hwnd, Int32 msg, IntPtr wParam, IntPtr lParam)
       at MS.Win32.UnsafeNativeMethods.DispatchMessage(MSG& msg)
       at System.Windows.Threading.Dispatcher.PushFrameImpl(DispatcherFrame frame)
       at System.Windows.Threading.Dispatcher.PushFrame(DispatcherFrame frame)
       at System.Windows.Threading.Dispatcher.Run()
       at System.Windows.Application.RunDispatcher(Object ignore)
       at System.Windows.Application.RunInternal(Window window)
       at System.Windows.Application.Run(Window window)
       at System.Windows.Application.Run()
       at Life.Store.Client.App.Main() in C:\Users\daniel\Documents\open-source\Life.Store\src\Life.Store.Client\obj\x86\Debug\App.g.cs:line 0
       at System.AppDomain._nExecuteAssembly(RuntimeAssembly assembly, String[] args)
       at System.AppDomain.ExecuteAssembly(String assemblyFile, Evidence assemblySecurity, String[] args)
       at Microsoft.VisualStudio.HostingProcess.HostProc.RunUsersAssembly()
       at System.Threading.ThreadHelper.ThreadStart_Context(Object state)
       at System.Threading.ExecutionContext.Run(ExecutionContext executionContext, ContextCallback callback, Object state, Boolean ignoreSyncCtx)
       at System.Threading.ExecutionContext.Run(ExecutionContext executionContext, ContextCallback callback, Object state)
       at System.Threading.ThreadHelper.ThreadStart()
  InnerException: