var s = 'hhollliillpiiii';
var sinvocales = s.replace(/[aeiouAEIOU]/g, '');
console.log(sinvocales); // imprime "hhlllllp"

var s = 'hhollliillpiiii';
var sinvocales = s.match(/[^aeiouAEIOU]/g);
console.log(sinvocales); // imprime ["h", "h", "l", "l", "l", "l", "l", "p"]

/([^aeiou]{2,})/gi