- The Avian Flue falls under stages one and two of the Epidemiological Transition because it infects human resulting in a likely death.
- The black plague also falls in the same stage as the Avian flue in the Epideiologic Transition. Like the Avian Flue, the black plague is quickly spread from human to human resulting in a sickness and possible death. Both diseases are common diseases which are spread through animals. Avian flue being birds, and black plague was spread from rats.
- This disease is most likely to spread from the interactions of humans. It only takes one person to come into contact with a bird to get Avian Flue. If that person who has the flue comes into contact with another person, it quickly spreads basically being passed on from one person to another. Something so sickly can quickly harm a lot of people.