Mewtwo has a similar origin and personality to the Mewtwo that appeared in the anime. It is a genetically engineered Pokémon created by Blaine for Team Rocket by splicing Mew's DNA with his own. Blaine later defected from Team Rocket and hid himself away, as both he and Mewtwo were suffering from an illness caused by a shared psychic link due to their mutual DNA. Mewtwo went on a rampage and hid itself in the Cerulean Cave, but Red was able to capture him with a Master Ball and return him to Blaine so he could attempt to show the mutant compassion and, if possible, find a cure for their illness. Blaine and Mewtwo fought against Lance two years later, but were defeated when their condition weakened them and Blaine collapsed. The pair were later cured by the flames of Entei whom Blaine had earlier befriended and partnered with. Later, Blaine left Mewtwo on his own, and the legendary Pokémon only returned when he learned of Giovanni's plans to use Deoxys for nefarious purposes. Mewtwo joined up with Red to attempt to defeat Deoxys and Giovanni, and with Red's help managed to defeat the duo after a tough fight that nearly killed him. It has a Quiet nature.