import numpy as np; np.random.seed(42)
import pandas as pd
import matplotlib.pyplot as plt

Index = [ 1.0,  2.0,  3.0,  4.0,  5.0]
Cols  = [10.0, 20.0, 30.0, 40.0, 50.0]
df = pd.DataFrame(abs(np.random.randn(5, 5)),
    index=Index, columns=Cols)
plt.close(1)
fig,ax = plt.subplots(num=1)
dx = np.diff(df.columns)[0]/2
dy = np.diff(df.index)[0]/2
extent = [df.columns.min()-dx, df.columns.max()+dx,
          df.index.min()-dy, df.index.max()+dy]
ax.imshow(df, extent=extent, aspect="auto")

plt.show()