import string
fhand = open("Hemingway.txt")
for fline in fhand:
    fline = fline.rstrip()
    print(fline.translate(string.punctuation))

import string

# Thanks to Martijn Pieters for this improved version

# This uses the 3-argument version of str.maketrans
# with arguments (x, y, z) where 'x' and 'y'
# must be equal-length strings and characters in 'x'
# are replaced by characters in 'y'. 'z'
# is a string (string.punctuation here)
# where each character in the string is mapped
# to None
translator = str.maketrans('', '', string.punctuation)

# This is an alternative that creates a dictionary mapping
# of every character from string.punctuation to None (this will
# also work)
#translator = str.maketrans(dict.fromkeys(string.punctuation))

s = 'string with "punctuation" inside of it! Does this work? I hope so.'

# pass the translator to the string's translate method.
print(s.translate(translator))

string with punctuation inside of it Does this work I hope so

import re
fline = re.sub('['+string.punctuation+']', '', fline)

import string
#make translator object
translator=str.maketrans('','',string.punctuation)
string_name=string_name.translate(translator)

for ch in string.punctuation:
    s = s.replace(ch, "'")