div {
    width: 50px;
    height: 50px;
    background-color: blue;
    position: relative;
    animation-name: exemplo;
    animation-duration: 4s;
    animation-iteration-count: infinite;
}
@keyframes exaemplo {
    0%   {background-color:blue; left:0px; top:0px;}
    25%  {background-color:yellow; left:200px; top:0px;}
    50%  {background-color:red; left:200px; top:200px;}
    75%  {background-color:green; left:0px; top:200px;}
    100% {background-color:red; left:0px; top:0px;}
}