# This function takes A and M-values (or any X and Y )
lowessNormalization <- function(x, y, include = TRUE, line = NULL,
         ...) {
         isFinite <- (is.finite(x) & is.finite(y))
         if (any(isFinite)){
             if (is.null(line)) {
                 line <- lowess(x[isFinite & include], y[isFinite &
                     include], ...)
             }
             y[isFinite] <- y[isFinite] - approx(line, xout = x[isFinite],
                 ties = mean)$y
         }

         y
 }