The error:
Unsafe permissions on credentials configuration file: 
/config/dns-conf/cloudflare.ini
Cleaning up challenges
Error determining zone_id: 9103 Unknown X-Auth-Key or 
X-Auth-Email. Please confirm that you have supplied va
lid Cloudflare API credentials. (Did you enter the cor
rect email address?)
ERROR: Cert does not exist! Please see the validation 
error above. Make sure you entered correct credentials
 into the /config/dns-conf/cloudflare.ini file.

The cloudflare.ini file:
dns_cloudflare_email = rTnose@.com
dns_cloudflare_api_key = 123455667778fhjkkllojhgfff

Docker-compose file:
letsencrypt:
image: linuxserver/letsencrypt
container_name: letsencrypt
cap_add:
- NET_ADMIN
environment:
- PUID=1000
- PGID=1000
- TZ=Europe/Stockholm
- URL=Domain1.io
- SUBDOMAINS:wildcard
- VALIDATION=dns
- DNSPLUGIN=cloudflare
- EMAIL=rTnose@.com
- ONLY_SUBDOMAINS=false
- EXTRA_DOMAINS=Domain2.io
volumes:
- /appdata/letsencrypt/:/config
ports:
- 443:443
- 80:80
restart: unless-stopped

On Cloudflare I have these two domains, both set to strict ssl.
Both domains has Origin Certificates, domain and *.domain.io
The cloud icon is set to grey.