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- HTTP/1.1 100
- HTTP/1.1 201
- Location: http://localhost:8080/swordv2/edit/7bc95608-9ac0-49e3-9750-d04d906ecc53
- Last-Modified: Do, 21 Dez 2017 13:56:20 +0100
- Content-MD5: 983fb6c49507d6040b3f9f26949aeda3
- Content-Type: application/atom+xml; type=entry;charset=UTF-8
- Transfer-Encoding: chunked
- Date: Thu, 21 Dec 2017 12:56:21 GMT
- <entry xmlns="http://www.w3.org/2005/Atom"><content type="application/zip" src="http://localhost:8080/swordv2/edit-media/7bc95608-9ac0-49e3-9750-d04d906ecc53" /><link href="http://localhost:8080/swordv2/edit-media/7bc95608-9ac0-49e3-9750-d04d906ecc53" rel="edit-media" type="application/zip" /><creator xmlns="http://purl.org/dc/terms/">Jeffreys, A.J.</creator><provenance xmlns="http://purl.org/dc/terms/">Made available in DSpace on 2017-12-21T12:56:19Z (GMT). No. of bitstreams: 3
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- Previous issue date: 2001-02</provenance><available xmlns="http://purl.org/dc/terms/">2017-12-21T12:56:19Z</available><publisher xmlns="http://purl.org/dc/terms/">Humboldt-Universität zu Berlin</publisher><title xmlns="http://purl.org/dc/terms/">Attempts to detect retrotransposition
- and de novo deletion of Alus and other
- dispersed repeats at specific loci in
- the human genome</title><type xmlns="http://purl.org/dc/terms/">Journal Article</type><issued xmlns="http://purl.org/dc/terms/">2001-02</issued><summary type="text">Dispersed repeat elements contribute to
- genome instability by de novo insertion
- and unequal recombination between
- repeats. To study the dynamics of these
- processes, we have developed single DNA
- molecule approaches to detect de novo
- insertions at a single locus and
- Alu-mediated deletions at two different
- loci in human genomic DNA. Validation
- experiments showed these approaches
- could detect insertions and deletions at
- frequencies below 10(-6) per cell.
- However, bulk analysis of germline
- (sperm) and somatic DNA showed no
- evidence for genuine mutant molecules,
- placing an upper limit of insertion and
- deletion rates of 2 x 10(-7) and 3 x
- 10(-7), respectively, in the individuals
- tested. Such re-arrangements at these
- loci therefore occur at a rate lower
- than that detectable by the most
- sensitive methods currently available.</summary><author><name>Jeffreys, A.J.</name></author><title type="text">Attempts to detect retrotransposition
- and de novo deletion of Alus and other
- dispersed repeats at specific loci in
- the human genome</title><rights type="text">localhost:8080/xmlui/bitstream/18452/19216/4/license.txt </rights><updated>2017-12-20T23:00:00.000Z</updated><generator uri="http://www.dspace.org/ns/sword/2.0/" version="2.0">uttam.dhakal@hu-berlin.de</generator><id>http://localhost:8080/swordv2/edit/7bc95608-9ac0-49e3-9750-d04d906ecc53</id><link href="http://localhost:8080/swordv2/edit/7bc95608-9ac0-49e3-9750-d04d906ecc53" rel="edit" /><link href="http://localhost:8080/swordv2/edit/7bc95608-9ac0-49e3-9750-d04d906ecc53" rel="http://purl.org/net/sword/terms/add" /><link href="http://localhost:8080/swordv2/edit-media/7bc95608-9ac0-49e3-9750-d04d906ecc53.atom" rel="edit-media" type="application/atom+xml; type=feed" /><packaging xmlns="http://purl.org/net/sword/terms/">http://purl.org/net/sword/package/SimpleZip</packaging><link href="http://localhost:8080/swordv2/statement/7bc95608-9ac0-49e3-9750-d04d906ecc53.rdf" rel="http://purl.org/net/sword/terms/statement" type="application/rdf+xml" /><link href="http://localhost:8080/swordv2/statement/7bc95608-9ac0-49e3-9750-d04d906ecc53.atom" rel="http://purl.org/net/sword/terms/statement" type="application/atom+xml; type=feed" /><treatment xmlns="http://purl.org/net/sword/terms/">The package has been deposited into DSpace. Each file has been unpacked and provided with a unique identifier. The metadata in the manifest has been extracted and attached to the DSpace item, which has been provided with an identifier leading to an HTML splash page.</treatment><link href="localhost:8080/xmlui/handle/18452/19216" rel="alternate" /></entry>
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