using (DirectoryEntry entry = new DirectoryEntry())
{
    entry.Username = "here goes the username you want to validate";
    entry.Password = "here goes the password";

    DirectorySearcher searcher = new DirectorySearcher(entry);

    searcher.Filter = "(objectclass=user)";

    try
    {
        searcher.FindOne();
    }
    catch (COMException ex)
    {
        if (ex.ErrorCode == -2147023570)
        {
            // Login or password is incorrect
        }
    }
}

// FindOne() didn't throw, the credentials are correct